node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMBX1 | ETS1 | ENSGALP00000032474 | ENSGALP00000001715 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Transforming protein p68/c-ets-1; Probable transcription factor. | 0.440 |
DMBX1 | LHX3 | ENSGALP00000032474 | ENSGALP00000002660 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | 0.472 |
DMBX1 | NEUROD1 | ENSGALP00000032474 | ENSGALP00000014468 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. | 0.431 |
DMBX1 | OTX2 | ENSGALP00000032474 | ENSGALP00000045234 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Homeodomain transcription factor. | 0.558 |
DMBX1 | POU1F1 | ENSGALP00000032474 | ENSGALP00000045301 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. | 0.463 |
DMBX1 | PRDM4 | ENSGALP00000032474 | ENSGALP00000020571 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. | 0.552 |
DMBX1 | SIK3 | ENSGALP00000032474 | ENSGALP00000046403 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | SIK family kinase 3. | 0.631 |
DMBX1 | SIX3 | ENSGALP00000032474 | ENSGALP00000058342 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.502 |
DMBX1 | SOX8 | ENSGALP00000032474 | ENSGALP00000008435 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. | 0.538 |
DMBX1 | ZIC1 | ENSGALP00000032474 | ENSGALP00000054372 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). | 0.462 |
ETS1 | DMBX1 | ENSGALP00000001715 | ENSGALP00000032474 | Transforming protein p68/c-ets-1; Probable transcription factor. | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | 0.440 |
ETS1 | SOX8 | ENSGALP00000001715 | ENSGALP00000008435 | Transforming protein p68/c-ets-1; Probable transcription factor. | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. | 0.707 |
ETS1 | ZIC1 | ENSGALP00000001715 | ENSGALP00000054372 | Transforming protein p68/c-ets-1; Probable transcription factor. | Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). | 0.684 |
LHX3 | DMBX1 | ENSGALP00000002660 | ENSGALP00000032474 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | 0.472 |
LHX3 | NEUROD1 | ENSGALP00000002660 | ENSGALP00000014468 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. | 0.746 |
LHX3 | OTX2 | ENSGALP00000002660 | ENSGALP00000045234 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | Homeodomain transcription factor. | 0.681 |
LHX3 | POU1F1 | ENSGALP00000002660 | ENSGALP00000045301 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. | 0.754 |
LHX3 | SIX3 | ENSGALP00000002660 | ENSGALP00000058342 | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.439 |
NEUROD1 | DMBX1 | ENSGALP00000014468 | ENSGALP00000032474 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. Required for brain development. | 0.431 |
NEUROD1 | LHX3 | ENSGALP00000014468 | ENSGALP00000002660 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. | LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. | 0.746 |