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creN7 creN7 SiRe_1109 SiRe_1109 pyrH pyrH albA-2 albA-2 SiRe_1112 SiRe_1112 SiRe_1449 SiRe_1449 SiRe_1108 SiRe_1108 SiRe_2190 SiRe_2190 csl4 csl4 rgy-2 rgy-2 SiRe_1113 SiRe_1113
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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creN7Chromatin protein Cren7; A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils. Belongs to the Cren7 family. (60 aa)    
Predicted Functional Partners:
SiRe_1109
Conserved hypothetical protein.
       0.713
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
       0.713
albA-2
DNA/RNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.
     
 0.609
SiRe_1112
Short-chain dehydrogenase/reductase SDR.
       0.575
SiRe_1449
Methyltransferase, unknown function; Catalyzes the methylation of lysine residues in target proteins, using S-adenosyl-L-methionine (SAM) as the methyl donor. Exhibits broad substrate specificity, being able to methylate the crenarchaeal chromatin protein Cren7 primarily at 'Lys-11', 'Lys-16' and 'Lys-31', as well as a number of recombinant Sulfolobus proteins in vitro. Methylates lysine residues in a rather sequence-independent manner.
      
 0.560
SiRe_1108
Transcriptional regulator, AsnC family.
     
 0.531
SiRe_2190
Maltose binding protein.
      
 0.531
csl4
RNA binding S1 domain protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.
      
 0.513
rgy-2
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
      
 0.482
SiRe_1113
3-hydroxyisobutyrate dehydrogenase.
       0.479
Your Current Organism:
Sulfolobus islandicus
NCBI taxonomy Id: 930945
Other names: S. islandicus REY15A, Sulfolobus islandicus REY15A, Sulfolobus islandicus str. REY15A, Sulfolobus islandicus strain REY15A
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