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ABCG2 ABCG2 ABCC2 ABCC2 ABCC1 ABCC1 ABCG5 ABCG5 SLC2A9 SLC2A9 SLC22A11 SLC22A11 GHR GHR SLC22A18 SLC22A18 SLC5A8 SLC5A8 EPHX1 EPHX1 SLC17A1 SLC17A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
ABCG2Broad substrate specificity ATP-binding cassette transporter ABCG2; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extra [...] (653 aa)    
Predicted Functional Partners:
ABCC2
Uncharacterized protein.
   
 0.921
ABCC1
ATP binding cassette subfamily C member 1.
   
 0.916
ABCG5
ATP binding cassette subfamily G member 5.
   
0.821
SLC2A9
Solute carrier family 2 member 9; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
   
  
 0.717
SLC22A11
Solute carrier family 22 member 12.
   
 
 0.654
GHR
Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).
   
  
 0.652
SLC22A18
MFS domain-containing protein.
      
 0.651
SLC5A8
Solute carrier family 5 member 8; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
    
 
 0.651
EPHX1
Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.
   
  
 0.619
SLC17A1
Solute carrier family 17 member 1.
      
 0.600
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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