STRINGSTRING
BGLAP BGLAP RUNX2 RUNX2 GGCX GGCX IBSP IBSP GPRC6A GPRC6A ALPL ALPL MGP MGP BMP2 BMP2 SPP1 SPP1 SPARC SPARC COL1A1 COL1A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)    
Predicted Functional Partners:
RUNX2
Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
    
 0.923
GGCX
Gamma-glutamyl carboxylase.
     
 0.847
IBSP
Integrin binding sialoprotein.
   
  
 0.765
GPRC6A
G protein-coupled receptor class C group 6 member A.
      
 0.763
ALPL
Alkaline phosphatase.
      
 0.748
MGP
Matrix Gla protein; Associates with the organic matrix of bone and cartilage.
      
 0.717
BMP2
Bone morphogenetic protein 2.
      
 0.704
SPP1
Secreted phosphoprotein 1.
      
 0.672
SPARC
Secreted protein acidic and cysteine rich.
      
 0.671
COL1A1
Collagen type I alpha 1 chain.
      
 0.660
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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