node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SNAP23 | SNAP25 | ENSPPYP00000007248 | ENSPPYP00000011970 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | 0.476 |
SNAP23 | SNAP29 | ENSPPYP00000007248 | ENSPPYP00000013412 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.807 |
SNAP23 | STX12 | ENSPPYP00000007248 | ENSPPYP00000001911 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.966 |
SNAP23 | STX6 | ENSPPYP00000007248 | ENSPPYP00000000510 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Syntaxin-6; Involved in intracellular vesicle trafficking. | 0.951 |
SNAP23 | STX7 | ENSPPYP00000007248 | ENSPPYP00000019051 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). | 0.950 |
SNAP23 | STX8 | ENSPPYP00000007248 | ENSPPYP00000008962 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | STX8 isoform 2. | 0.596 |
SNAP23 | VAMP4 | ENSPPYP00000007248 | ENSPPYP00000000592 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | VAMP4 isoform 1. | 0.825 |
SNAP23 | VAMP7 | ENSPPYP00000007248 | ENSPPYP00000023405 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.998 |
SNAP23 | VTI1A | ENSPPYP00000007248 | ENSPPYP00000003095 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | Vesicle transport through interaction with t-SNAREs 1A. | 0.422 |
SNAP23 | YKT6 | ENSPPYP00000007248 | ENSPPYP00000019721 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. | 0.486 |
SNAP25 | SNAP23 | ENSPPYP00000011970 | ENSPPYP00000007248 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.476 |
SNAP25 | SNAP29 | ENSPPYP00000011970 | ENSPPYP00000013412 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | 0.823 |
SNAP25 | STX12 | ENSPPYP00000011970 | ENSPPYP00000001911 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.888 |
SNAP25 | STX6 | ENSPPYP00000011970 | ENSPPYP00000000510 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Syntaxin-6; Involved in intracellular vesicle trafficking. | 0.791 |
SNAP25 | STX7 | ENSPPYP00000011970 | ENSPPYP00000019051 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). | 0.577 |
SNAP25 | STX8 | ENSPPYP00000011970 | ENSPPYP00000008962 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | STX8 isoform 2. | 0.435 |
SNAP25 | VAMP4 | ENSPPYP00000011970 | ENSPPYP00000000592 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | VAMP4 isoform 1. | 0.717 |
SNAP25 | VAMP7 | ENSPPYP00000011970 | ENSPPYP00000023405 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.974 |
SNAP25 | YKT6 | ENSPPYP00000011970 | ENSPPYP00000019721 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. | YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. | 0.596 |
SNAP29 | SNAP23 | ENSPPYP00000013412 | ENSPPYP00000007248 | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. | Synaptosomal-associated protein; Belongs to the SNAP-25 family. | 0.807 |