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KRT84 KRT84 KRT36 KRT36 KRTAP3-1 KRTAP3-1 KRTAP13-1 KRTAP13-1 DSG4 DSG4 KRT76 KRT76 KRT83 KRT83 KRT82 KRT82 OR6X1 OR6X1 HOXC13 HOXC13 KRT74 KRT74
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT84Keratin, type II cuticular Hb4; Keratin 84. (600 aa)    
Predicted Functional Partners:
KRT36
Keratin, type I cuticular Ha6; Keratin 36; Belongs to the intermediate filament family.
  
  
0.609
KRTAP3-1
Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
   
  
 0.572
KRTAP13-1
Keratin-associated protein 13-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
   
  
 0.566
DSG4
Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
   
  
 0.550
KRT76
Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. Belongs to the intermediate filament family.
  
 
0.528
KRT83
Keratin, type II cuticular Hb3; Keratin 83; Belongs to the intermediate filament family.
  
0.518
KRT82
Keratin, type II cuticular Hb2; Keratin 82; Belongs to the intermediate filament family.
  
 
0.516
OR6X1
Olfactory receptor 6X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.506
HOXC13
Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair- specific genes (By similarity); Belongs to the Abd-B homeobox family.
   
  
 0.489
KRT74
Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
  
 
0.475
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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