node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AVPR2 | C1QTNF1 | ENSP00000496396 | ENSP00000340864 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | 0.833 |
C1QL1 | C1QTNF1 | ENSP00000253407 | ENSP00000340864 | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | 0.497 |
C1QL3 | C1QTNF1 | ENSP00000298943 | ENSP00000340864 | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | 0.465 |
C1QL3 | C1QTNF12 | ENSP00000298943 | ENSP00000329137 | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | 0.584 |
C1QL3 | ERFE | ENSP00000298943 | ENSP00000442304 | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Belongs to the adipolin/erythroferrone family. | 0.435 |
C1QTNF1 | AVPR2 | ENSP00000340864 | ENSP00000496396 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.833 |
C1QTNF1 | C1QL1 | ENSP00000340864 | ENSP00000253407 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). | 0.497 |
C1QTNF1 | C1QL3 | ENSP00000340864 | ENSP00000298943 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). | 0.465 |
C1QTNF1 | C1QTNF12 | ENSP00000340864 | ENSP00000329137 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | 0.541 |
C1QTNF1 | C1QTNF6 | ENSP00000340864 | ENSP00000338812 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6. | 0.794 |
C1QTNF1 | COL21A1 | ENSP00000340864 | ENSP00000244728 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Collagen type XXI alpha 1 chain. | 0.616 |
C1QTNF1 | COL4A1 | ENSP00000340864 | ENSP00000364979 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | 0.486 |
C1QTNF1 | COL4A2 | ENSP00000340864 | ENSP00000353654 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. | 0.470 |
C1QTNF1 | ERFE | ENSP00000340864 | ENSP00000442304 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Belongs to the adipolin/erythroferrone family. | 0.624 |
C1QTNF1 | TNF | ENSP00000340864 | ENSP00000398698 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T- cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 [...] | 0.528 |
C1QTNF12 | C1QL3 | ENSP00000329137 | ENSP00000298943 | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity). | 0.584 |
C1QTNF12 | C1QTNF1 | ENSP00000329137 | ENSP00000340864 | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | 0.541 |
C1QTNF12 | C1QTNF6 | ENSP00000329137 | ENSP00000338812 | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6. | 0.518 |
C1QTNF6 | C1QTNF1 | ENSP00000338812 | ENSP00000340864 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6. | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1. | 0.794 |
C1QTNF6 | C1QTNF12 | ENSP00000338812 | ENSP00000329137 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6. | Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. | 0.518 |