node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOOL | RPS6KA6 | ENSP00000362268 | ENSP00000262752 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | 0.555 |
APOOL | SH3BGRL | ENSP00000362268 | ENSP00000362308 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.539 |
CNGB1 | SH3BGRL | ENSP00000251102 | ENSP00000362308 | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.834 |
EGFR | SH3BGRL | ENSP00000275493 | ENSP00000362308 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at leas [...] | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.801 |
HMGN1 | PSMG1 | ENSP00000370125 | ENSP00000329915 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Belongs to the HMGN family. | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | 0.731 |
HMGN1 | SH3BGRL | ENSP00000370125 | ENSP00000362308 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Belongs to the HMGN family. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.848 |
LCA5L | PSMG1 | ENSP00000351008 | ENSP00000329915 | Lebercilin-like protein; Lebercilin LCA5 like. | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | 0.697 |
LCA5L | SH3BGRL | ENSP00000351008 | ENSP00000362308 | Lebercilin-like protein; Lebercilin LCA5 like. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.568 |
PHKB | SH3BGRL | ENSP00000313504 | ENSP00000362308 | Phosphorylase b kinase regulatory subunit beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.470 |
PSMG1 | HMGN1 | ENSP00000329915 | ENSP00000370125 | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Belongs to the HMGN family. | 0.731 |
PSMG1 | LCA5L | ENSP00000329915 | ENSP00000351008 | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | Lebercilin-like protein; Lebercilin LCA5 like. | 0.697 |
PSMG1 | SH3BGRL | ENSP00000329915 | ENSP00000362308 | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.532 |
RAB7B | SH3BGRL | ENSP00000479762 | ENSP00000362308 | Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation [...] | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.594 |
RPS6KA6 | APOOL | ENSP00000262752 | ENSP00000362268 | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.555 |
RPS6KA6 | SH3BGRL | ENSP00000262752 | ENSP00000362308 | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.489 |
SELENOO | SH3BGRL | ENSP00000370288 | ENSP00000362308 | Protein adenylyltransferase SelO, mitochondrial; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein. Belongs to the SELO family. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.594 |
SH3BGRL | APOOL | ENSP00000362308 | ENSP00000362268 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.539 |
SH3BGRL | CNGB1 | ENSP00000362308 | ENSP00000251102 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. | 0.834 |
SH3BGRL | EGFR | ENSP00000362308 | ENSP00000275493 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at leas [...] | 0.801 |
SH3BGRL | HMGN1 | ENSP00000362308 | ENSP00000370125 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). Belongs to the HMGN family. | 0.848 |