node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA10 | CTSE | ENSP00000352248 | ENSP00000350911 | Annexin A10. | Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. | 0.567 |
ANXA10 | VSIG1 | ENSP00000352248 | ENSP00000402219 | Annexin A10. | V-set and immunoglobulin domain containing 1. | 0.543 |
CACNG4 | VSIG1 | ENSP00000262138 | ENSP00000402219 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | V-set and immunoglobulin domain containing 1. | 0.433 |
CLDN18 | CTSE | ENSP00000340939 | ENSP00000350911 | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. | 0.472 |
CLDN18 | GKN1 | ENSP00000340939 | ENSP00000501093 | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.407 |
CLDN18 | VSIG1 | ENSP00000340939 | ENSP00000402219 | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | V-set and immunoglobulin domain containing 1. | 0.486 |
CST9L | VSIG1 | ENSP00000366178 | ENSP00000402219 | Cystatin-9-like; Cystatin 9 like; Belongs to the cystatin family. | V-set and immunoglobulin domain containing 1. | 0.487 |
CTSE | ANXA10 | ENSP00000350911 | ENSP00000352248 | Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. | Annexin A10. | 0.567 |
CTSE | CLDN18 | ENSP00000350911 | ENSP00000340939 | Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.472 |
CTSE | VSIG1 | ENSP00000350911 | ENSP00000402219 | Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. | V-set and immunoglobulin domain containing 1. | 0.557 |
FATE1 | VSIG1 | ENSP00000359375 | ENSP00000402219 | Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. | V-set and immunoglobulin domain containing 1. | 0.428 |
GJB5 | VSIG1 | ENSP00000340811 | ENSP00000402219 | Gap junction beta-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | V-set and immunoglobulin domain containing 1. | 0.433 |
GKN1 | CLDN18 | ENSP00000501093 | ENSP00000340939 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.407 |
GKN1 | VSIG1 | ENSP00000501093 | ENSP00000402219 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | V-set and immunoglobulin domain containing 1. | 0.476 |
IGSF11 | VSIG1 | ENSP00000377370 | ENSP00000402219 | Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth. | V-set and immunoglobulin domain containing 1. | 0.454 |
IZUMO1 | VSIG1 | ENSP00000327786 | ENSP00000402219 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. | V-set and immunoglobulin domain containing 1. | 0.442 |
VSIG1 | ANXA10 | ENSP00000402219 | ENSP00000352248 | V-set and immunoglobulin domain containing 1. | Annexin A10. | 0.543 |
VSIG1 | CACNG4 | ENSP00000402219 | ENSP00000262138 | V-set and immunoglobulin domain containing 1. | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | 0.433 |
VSIG1 | CLDN18 | ENSP00000402219 | ENSP00000340939 | V-set and immunoglobulin domain containing 1. | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.486 |
VSIG1 | CST9L | ENSP00000402219 | ENSP00000366178 | V-set and immunoglobulin domain containing 1. | Cystatin-9-like; Cystatin 9 like; Belongs to the cystatin family. | 0.487 |