node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP17A | EVI5L | ENSP00000324827 | ENSP00000445905 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | 0.482 |
AKAP17A | MRPL30 | ENSP00000324827 | ENSP00000338057 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Mitochondrial ribosomal protein L30. | 0.468 |
AKAP17A | POGK | ENSP00000324827 | ENSP00000356849 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Pogo transposable element derived with KRAB domain. | 0.470 |
CPLANE2 | EVI5L | ENSP00000364749 | ENSP00000445905 | Ciliogenesis and planar polarity effector 2; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | 0.460 |
CPLANE2 | RAB23 | ENSP00000364749 | ENSP00000417610 | Ciliogenesis and planar polarity effector 2; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). | Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 pr [...] | 0.613 |
EVI5L | AKAP17A | ENSP00000445905 | ENSP00000324827 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | 0.482 |
EVI5L | CPLANE2 | ENSP00000445905 | ENSP00000364749 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Ciliogenesis and planar polarity effector 2; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). | 0.460 |
EVI5L | MAP3K10 | ENSP00000445905 | ENSP00000253055 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.780 |
EVI5L | MRPL30 | ENSP00000445905 | ENSP00000338057 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Mitochondrial ribosomal protein L30. | 0.461 |
EVI5L | POGK | ENSP00000445905 | ENSP00000356849 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Pogo transposable element derived with KRAB domain. | 0.507 |
EVI5L | PRR36 | ENSP00000445905 | ENSP00000482374 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Proline-rich protein 36; Proline rich 36. | 0.507 |
EVI5L | RAB10 | ENSP00000445905 | ENSP00000264710 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles [...] | 0.464 |
EVI5L | RAB11A | ENSP00000445905 | ENSP00000261890 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] | 0.518 |
EVI5L | RAB23 | ENSP00000445905 | ENSP00000417610 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 pr [...] | 0.700 |
EVI5L | RHOBTB2 | ENSP00000445905 | ENSP00000427926 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | Rho-related BTB domain-containing protein 2; Rho related BTB domain containing 2; Belongs to the small GTPase superfamily. Rho family. | 0.463 |
MAP3K10 | EVI5L | ENSP00000253055 | ENSP00000445905 | Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | 0.780 |
MRPL30 | AKAP17A | ENSP00000338057 | ENSP00000324827 | Mitochondrial ribosomal protein L30. | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | 0.468 |
MRPL30 | EVI5L | ENSP00000338057 | ENSP00000445905 | Mitochondrial ribosomal protein L30. | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity. | 0.461 |
MRPL30 | POGK | ENSP00000338057 | ENSP00000356849 | Mitochondrial ribosomal protein L30. | Pogo transposable element derived with KRAB domain. | 0.506 |
POGK | AKAP17A | ENSP00000356849 | ENSP00000324827 | Pogo transposable element derived with KRAB domain. | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | 0.470 |