node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGF | EGFR | ENSSSCP00000028117 | ENSSSCP00000068369 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Receptor protein-tyrosine kinase. | 0.999 |
EGF | ERBB2 | ENSSSCP00000028117 | ENSSSCP00000018545 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Receptor protein-tyrosine kinase. | 0.983 |
EGF | ERBB3 | ENSSSCP00000028117 | ENSSSCP00000019799 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Erb-b2 receptor tyrosine kinase 3. | 0.985 |
EGF | ERBB4 | ENSSSCP00000028117 | ENSSSCP00000017120 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Receptor protein-tyrosine kinase. | 0.989 |
EGF | EREG | ENSSSCP00000028117 | ENSSSCP00000067883 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Epiregulin. | 0.729 |
EGF | IGF1 | ENSSSCP00000028117 | ENSSSCP00000000915 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.989 |
EGF | INS | ENSSSCP00000028117 | ENSSSCP00000044635 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.994 |
EGF | PDGFA | ENSSSCP00000028117 | ENSSSCP00000008054 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.931 |
EGF | PDGFC | ENSSSCP00000028117 | ENSSSCP00000024797 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.907 |
EGF | TGFA | ENSSSCP00000028117 | ENSSSCP00000008889 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. | 0.974 |
EGFR | EGF | ENSSSCP00000068369 | ENSSSCP00000028117 | Receptor protein-tyrosine kinase. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). | 0.999 |
EGFR | ERBB2 | ENSSSCP00000068369 | ENSSSCP00000018545 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.998 |
EGFR | ERBB3 | ENSSSCP00000068369 | ENSSSCP00000019799 | Receptor protein-tyrosine kinase. | Erb-b2 receptor tyrosine kinase 3. | 0.982 |
EGFR | ERBB4 | ENSSSCP00000068369 | ENSSSCP00000017120 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.889 |
EGFR | EREG | ENSSSCP00000068369 | ENSSSCP00000067883 | Receptor protein-tyrosine kinase. | Epiregulin. | 0.998 |
EGFR | IGF1 | ENSSSCP00000068369 | ENSSSCP00000000915 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.962 |
EGFR | INS | ENSSSCP00000068369 | ENSSSCP00000044635 | Receptor protein-tyrosine kinase. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.964 |
EGFR | PDGFA | ENSSSCP00000068369 | ENSSSCP00000008054 | Receptor protein-tyrosine kinase. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.930 |
EGFR | PDGFC | ENSSSCP00000068369 | ENSSSCP00000024797 | Receptor protein-tyrosine kinase. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.935 |
EGFR | TGFA | ENSSSCP00000068369 | ENSSSCP00000008889 | Receptor protein-tyrosine kinase. | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. | 0.998 |