STRINGSTRING
UCHL5 UCHL5 PSMD14 PSMD14 ADRM1 ADRM1 PSMC2 PSMC2 PSMD4 PSMD4 PSMD7 PSMD7 USP14 USP14 PSMD8 PSMD8 PSMD12 PSMD12 PSMC4 PSMC4 PSMA2 PSMA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UCHL5Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa)    
Predicted Functional Partners:
PSMD14
26S proteasome non-ATPase regulatory subunit 14.
   
 0.989
ADRM1
Adhesion regulating molecule 1.
   
 0.988
PSMC2
AAA domain-containing protein; Belongs to the AAA ATPase family.
   
 0.987
PSMD4
Proteasome 26S subunit, non-ATPase 4.
   
 0.986
PSMD7
Proteasome 26S subunit, non-ATPase 7.
   
 0.986
USP14
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
   
 
 0.985
PSMD8
26S proteasome non-ATPase regulatory subunit 8.
   
 0.985
PSMD12
26S proteasome non-ATPase regulatory subunit 12 isoform 1.
   
 0.982
PSMC4
Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.
   
 0.982
PSMA2
Proteasome endopeptidase complex.
   
 0.982
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.