STRINGSTRING
NFATC1 NFATC1 PPP3R1 PPP3R1 PPP3CA PPP3CA PPP3CB PPP3CB PPP3CC PPP3CC GSK3B GSK3B MAPK10 MAPK10 NFATC2 NFATC2 GATA4 GATA4 NFATC3 NFATC3 MEF2B MEF2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). (981 aa)    
Predicted Functional Partners:
PPP3R1
Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
    
 0.988
PPP3CA
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to t [...]
    
 0.982
PPP3CB
Serine/threonine-protein phosphatase.
    
 0.966
PPP3CC
Serine/threonine-protein phosphatase.
    
 0.962
GSK3B
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.955
MAPK10
Mitogen-activated protein kinase.
    
 0.951
NFATC2
Nuclear factor of activated T cells 2.
   
0.943
GATA4
GATA binding protein 4.
   
 0.937
NFATC3
Nuclear factor of activated T cells 3.
   
 
0.924
MEF2B
Myocyte enhancer factor 2B.
    
 0.923
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (28%) [HD]