node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GATA4 | GSK3B | ENSBTAP00000007134 | ENSBTAP00000051604 | GATA binding protein 4. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.558 |
GATA4 | NFATC1 | ENSBTAP00000007134 | ENSBTAP00000000859 | GATA binding protein 4. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | 0.937 |
GATA4 | NFATC2 | ENSBTAP00000007134 | ENSBTAP00000024318 | GATA binding protein 4. | Nuclear factor of activated T cells 2. | 0.928 |
GATA4 | NFATC3 | ENSBTAP00000007134 | ENSBTAP00000005727 | GATA binding protein 4. | Nuclear factor of activated T cells 3. | 0.937 |
GSK3B | GATA4 | ENSBTAP00000051604 | ENSBTAP00000007134 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | GATA binding protein 4. | 0.558 |
GSK3B | NFATC1 | ENSBTAP00000051604 | ENSBTAP00000000859 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | 0.955 |
GSK3B | NFATC2 | ENSBTAP00000051604 | ENSBTAP00000024318 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Nuclear factor of activated T cells 2. | 0.922 |
GSK3B | NFATC3 | ENSBTAP00000051604 | ENSBTAP00000005727 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Nuclear factor of activated T cells 3. | 0.920 |
GSK3B | PPP3CA | ENSBTAP00000051604 | ENSBTAP00000068601 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to t [...] | 0.934 |
GSK3B | PPP3CB | ENSBTAP00000051604 | ENSBTAP00000063744 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein phosphatase. | 0.925 |
GSK3B | PPP3CC | ENSBTAP00000051604 | ENSBTAP00000026818 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Serine/threonine-protein phosphatase. | 0.925 |
GSK3B | PPP3R1 | ENSBTAP00000051604 | ENSBTAP00000058561 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. | 0.923 |
MAPK10 | NFATC1 | ENSBTAP00000026712 | ENSBTAP00000000859 | Mitogen-activated protein kinase. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | 0.951 |
MAPK10 | NFATC2 | ENSBTAP00000026712 | ENSBTAP00000024318 | Mitogen-activated protein kinase. | Nuclear factor of activated T cells 2. | 0.520 |
MAPK10 | NFATC3 | ENSBTAP00000026712 | ENSBTAP00000005727 | Mitogen-activated protein kinase. | Nuclear factor of activated T cells 3. | 0.971 |
MEF2B | NFATC1 | ENSBTAP00000002377 | ENSBTAP00000000859 | Myocyte enhancer factor 2B. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | 0.923 |
MEF2B | NFATC2 | ENSBTAP00000002377 | ENSBTAP00000024318 | Myocyte enhancer factor 2B. | Nuclear factor of activated T cells 2. | 0.923 |
MEF2B | NFATC3 | ENSBTAP00000002377 | ENSBTAP00000005727 | Myocyte enhancer factor 2B. | Nuclear factor of activated T cells 3. | 0.922 |
NFATC1 | GATA4 | ENSBTAP00000000859 | ENSBTAP00000007134 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | GATA binding protein 4. | 0.937 |
NFATC1 | GSK3B | ENSBTAP00000000859 | ENSBTAP00000051604 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.955 |