node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT | ALDH4A1 | ENSBTAP00000007622 | ENSBTAP00000059236 | Serine--pyruvate aminotransferase. | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | 0.482 |
AGXT | AMT | ENSBTAP00000007622 | ENSBTAP00000002992 | Serine--pyruvate aminotransferase. | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.956 |
AGXT | DLD | ENSBTAP00000007622 | ENSBTAP00000033696 | Serine--pyruvate aminotransferase. | Dihydrolipoyl dehydrogenase. | 0.923 |
AGXT | GCSH | ENSBTAP00000007622 | ENSBTAP00000008936 | Serine--pyruvate aminotransferase. | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. | 0.930 |
AGXT | GLDC | ENSBTAP00000007622 | ENSBTAP00000036556 | Serine--pyruvate aminotransferase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.958 |
AGXT | SHMT1 | ENSBTAP00000007622 | ENSBTAP00000022732 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.991 |
AGXT | SHMT2 | ENSBTAP00000007622 | ENSBTAP00000038059 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.989 |
ALDH4A1 | AGXT | ENSBTAP00000059236 | ENSBTAP00000007622 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Serine--pyruvate aminotransferase. | 0.482 |
ALDH4A1 | AMT | ENSBTAP00000059236 | ENSBTAP00000002992 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.856 |
ALDH4A1 | DLD | ENSBTAP00000059236 | ENSBTAP00000033696 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Dihydrolipoyl dehydrogenase. | 0.878 |
ALDH4A1 | GCSH | ENSBTAP00000059236 | ENSBTAP00000008936 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. | 0.849 |
ALDH4A1 | GLDC | ENSBTAP00000059236 | ENSBTAP00000036556 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.838 |
AMT | AGXT | ENSBTAP00000002992 | ENSBTAP00000007622 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine--pyruvate aminotransferase. | 0.956 |
AMT | ALDH4A1 | ENSBTAP00000002992 | ENSBTAP00000059236 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity). | 0.856 |
AMT | DLD | ENSBTAP00000002992 | ENSBTAP00000033696 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Dihydrolipoyl dehydrogenase. | 0.995 |
AMT | GCSH | ENSBTAP00000002992 | ENSBTAP00000008936 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Belongs to the GcvH family. | 0.994 |
AMT | GLDC | ENSBTAP00000002992 | ENSBTAP00000036556 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
AMT | LIAS | ENSBTAP00000002992 | ENSBTAP00000019299 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.425 |
AMT | LIPT1 | ENSBTAP00000002992 | ENSBTAP00000005171 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | 0.479 |
AMT | LIPT2 | ENSBTAP00000002992 | ENSBTAP00000010820 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. | 0.409 |