node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | DKC1 | ENSBTAP00000025159 | ENSBTAP00000017339 | ACD shelterin complex subunit and telomerase recruitment factor. | Dyskerin pseudouridine synthase 1. | 0.588 |
ACD | NHP2 | ENSBTAP00000025159 | ENSBTAP00000008363 | ACD shelterin complex subunit and telomerase recruitment factor. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.559 |
ACD | NOP10 | ENSBTAP00000025159 | ENSBTAP00000036040 | ACD shelterin complex subunit and telomerase recruitment factor. | NOP10 ribonucleoprotein homolog (Yeast). | 0.547 |
ACD | POT1 | ENSBTAP00000025159 | ENSBTAP00000017541 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres 1. | 0.991 |
ACD | TEP1 | ENSBTAP00000025159 | ENSBTAP00000001564 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase associated protein 1. | 0.420 |
ACD | TERT | ENSBTAP00000025159 | ENSBTAP00000016685 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.917 |
ACD | WRAP53 | ENSBTAP00000025159 | ENSBTAP00000057850 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically b [...] | 0.571 |
CTNNB1 | SMARCA4 | ENSBTAP00000021838 | ENSBTAP00000059124 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Transcription activator BRG1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium- dependent release of a repressor complex and the recruitment of an activator complex. In resting ne [...] | 0.902 |
CTNNB1 | TCF7L1 | ENSBTAP00000021838 | ENSBTAP00000013336 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Transcription factor 7 like 1. | 0.995 |
CTNNB1 | TERT | ENSBTAP00000021838 | ENSBTAP00000016685 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.977 |
DKC1 | ACD | ENSBTAP00000017339 | ENSBTAP00000025159 | Dyskerin pseudouridine synthase 1. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.588 |
DKC1 | NHP2 | ENSBTAP00000017339 | ENSBTAP00000008363 | Dyskerin pseudouridine synthase 1. | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | 0.999 |
DKC1 | NOP10 | ENSBTAP00000017339 | ENSBTAP00000036040 | Dyskerin pseudouridine synthase 1. | NOP10 ribonucleoprotein homolog (Yeast). | 0.999 |
DKC1 | POT1 | ENSBTAP00000017339 | ENSBTAP00000017541 | Dyskerin pseudouridine synthase 1. | Protection of telomeres 1. | 0.655 |
DKC1 | TEP1 | ENSBTAP00000017339 | ENSBTAP00000001564 | Dyskerin pseudouridine synthase 1. | Telomerase associated protein 1. | 0.601 |
DKC1 | TERT | ENSBTAP00000017339 | ENSBTAP00000016685 | Dyskerin pseudouridine synthase 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.987 |
DKC1 | WRAP53 | ENSBTAP00000017339 | ENSBTAP00000057850 | Dyskerin pseudouridine synthase 1. | Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically b [...] | 0.997 |
NHP2 | ACD | ENSBTAP00000008363 | ENSBTAP00000025159 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | ACD shelterin complex subunit and telomerase recruitment factor. | 0.559 |
NHP2 | DKC1 | ENSBTAP00000008363 | ENSBTAP00000017339 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | Dyskerin pseudouridine synthase 1. | 0.999 |
NHP2 | NOP10 | ENSBTAP00000008363 | ENSBTAP00000036040 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] | NOP10 ribonucleoprotein homolog (Yeast). | 0.999 |