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FASN FASN ACLY ACLY ACACA ACACA UNG UNG MCAT MCAT ACSL1 ACSL1 AASDH AASDH MECR MECR ACSL3 ACSL3 ACSF3 ACSF3 ACSL5 ACSL5
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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FASN3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2515 aa)    
Predicted Functional Partners:
ACLY
ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
   
 0.997
ACACA
Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
  
 
 0.995
UNG
Acetyl-CoA carboxylase beta.
  
 
 0.990
MCAT
Malonyl-CoA-acyl carrier protein transacylase.
  
0.982
ACSL1
Acyl-CoA synthetase long chain family member 1.
   
 0.978
AASDH
Aminoadipate-semialdehyde dehydrogenase.
  
 0.976
MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). Belongs to the zinc-containing alcohol dehydrogenase family. Quin [...]
  
 0.971
ACSL3
Acyl-CoA synthetase long chain family member 3.
  
 0.967
ACSF3
Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 0.965
ACSL5
Acyl-CoA synthetase long-chain family member 5.
   
 0.962
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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