node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT3 | BCL2 | ENSOCUP00000041212 | ENSOCUP00000036189 | Non-specific serine/threonine protein kinase. | BH4_2 domain-containing protein. | 0.955 |
AKT3 | PPP2CA | ENSOCUP00000041212 | ENSOCUP00000013713 | Non-specific serine/threonine protein kinase. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | 0.955 |
AKT3 | PPP2CB | ENSOCUP00000041212 | ENSOCUP00000046534 | Non-specific serine/threonine protein kinase. | Serine/threonine-protein phosphatase. | 0.559 |
AKT3 | PPP2R1A | ENSOCUP00000041212 | ENSOCUP00000014689 | Non-specific serine/threonine protein kinase. | Protein phosphatase 2 scaffold subunit Aalpha. | 0.954 |
AKT3 | PPP2R1B | ENSOCUP00000041212 | ENSOCUP00000041612 | Non-specific serine/threonine protein kinase. | Protein phosphatase 2 scaffold subunit Abeta. | 0.951 |
AKT3 | PPP2R2D | ENSOCUP00000041212 | ENSOCUP00000020770 | Non-specific serine/threonine protein kinase. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.903 |
AKT3 | PPP2R5B | ENSOCUP00000041212 | ENSOCUP00000021664 | Non-specific serine/threonine protein kinase. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | 0.945 |
AKT3 | PTPA | ENSOCUP00000041212 | ENSOCUP00000044909 | Non-specific serine/threonine protein kinase. | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] | 0.909 |
BCL2 | AKT3 | ENSOCUP00000036189 | ENSOCUP00000041212 | BH4_2 domain-containing protein. | Non-specific serine/threonine protein kinase. | 0.955 |
BCL2 | PPP2CA | ENSOCUP00000036189 | ENSOCUP00000013713 | BH4_2 domain-containing protein. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | 0.913 |
BCL2 | PPP2R1A | ENSOCUP00000036189 | ENSOCUP00000014689 | BH4_2 domain-containing protein. | Protein phosphatase 2 scaffold subunit Aalpha. | 0.900 |
BCL2 | PPP2R1B | ENSOCUP00000036189 | ENSOCUP00000041612 | BH4_2 domain-containing protein. | Protein phosphatase 2 scaffold subunit Abeta. | 0.906 |
BCL2 | PPP2R2D | ENSOCUP00000036189 | ENSOCUP00000020770 | BH4_2 domain-containing protein. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.906 |
BCL2 | PPP2R5B | ENSOCUP00000036189 | ENSOCUP00000021664 | BH4_2 domain-containing protein. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | 0.909 |
PPP2CA | AKT3 | ENSOCUP00000013713 | ENSOCUP00000041212 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | Non-specific serine/threonine protein kinase. | 0.955 |
PPP2CA | BCL2 | ENSOCUP00000013713 | ENSOCUP00000036189 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | BH4_2 domain-containing protein. | 0.913 |
PPP2CA | PPP2R1A | ENSOCUP00000013713 | ENSOCUP00000014689 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | Protein phosphatase 2 scaffold subunit Aalpha. | 0.999 |
PPP2CA | PPP2R1B | ENSOCUP00000013713 | ENSOCUP00000041612 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | Protein phosphatase 2 scaffold subunit Abeta. | 0.999 |
PPP2CA | PPP2R2D | ENSOCUP00000013713 | ENSOCUP00000020770 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. | 0.973 |
PPP2CA | PPP2R5B | ENSOCUP00000013713 | ENSOCUP00000021664 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. | 0.979 |