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UBE2R2 UBE2R2 CDC34 CDC34 UBA1 UBA1 UBE2V1 UBE2V1 ENSOCUP00000035728 ENSOCUP00000035728 UBA6 UBA6 CUL3 CUL3 TRIP12 TRIP12 CUL1 CUL1 ENSOCUP00000044498 ENSOCUP00000044498 UBB UBB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
UBE2R2Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)    
Predicted Functional Partners:
CDC34
Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.
  
 
0.935
UBA1
Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).
   
 0.925
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
   
 0.890
ENSOCUP00000035728
Zf-rbx1 domain-containing protein.
   
 0.875
UBA6
Ubiquitin like modifier activating enzyme 6.
   
 0.855
CUL3
Cullin 3; Belongs to the cullin family.
   
 0.823
TRIP12
Thyroid hormone receptor interactor 12.
   
 0.822
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.776
ENSOCUP00000044498
Ribosomal_L40e domain-containing protein.
   
 0.775
UBB
Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]
   
 0.773
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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