Kfla_5830 protein (Kribbella flavida) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

Kfla_5830

PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein. (124 aa)

Predicted Functional Partners:

Kfla_5829

0.886

Kfla_5075

0.750

Kfla_3870

0.748

Kfla_3751

0.741

Kfla_3922

0.732

Kfla_4958

0.727

Kfla_6234

0.726

Kfla_3163

0.724

Kfla_4834

0.721

Kfla_1564

0.718

Your Current Organism:

Kribbella flavida

NCBI taxonomy Id: 479435
Other names: K. flavida DSM 17836, Kribbella flavida DSM 17836, Kribbella flavida str. DSM 17836, Kribbella flavida strain DSM 17836

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Kfla_1564	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: mxa:MXAN_5410 ECF subfamily RNA polymerase sigma factor.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.718
Kfla_3163	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; KEGG: scl:sce5149 ECF subfamily RNA polymerase sigma-70 factor.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.724
Kfla_3751	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.741
Kfla_3870	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.748
Kfla_3922	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; KEGG: ret:RHE_CH01322 putative RNA polymerase sigma factor protein (sigma-70).	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.732
Kfla_4834	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: mxa:MXAN_5410 ECF subfamily RNA polymerase sigma factor.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.721
Kfla_4958	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: bja:bll6612 hypothetical protein.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.727
Kfla_5075	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.750
Kfla_5829	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: scl:sce6417 ECF subfamily RNA polymerase sigma factor.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.886
Kfla_5830	Kfla_1564	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: mxa:MXAN_5410 ECF subfamily RNA polymerase sigma factor.	0.718
Kfla_5830	Kfla_3163	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; KEGG: scl:sce5149 ECF subfamily RNA polymerase sigma-70 factor.	0.724
Kfla_5830	Kfla_3751	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	0.741
Kfla_5830	Kfla_3870	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	0.748
Kfla_5830	Kfla_3922	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; KEGG: ret:RHE_CH01322 putative RNA polymerase sigma factor protein (sigma-70).	0.732
Kfla_5830	Kfla_4834	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: mxa:MXAN_5410 ECF subfamily RNA polymerase sigma factor.	0.721
Kfla_5830	Kfla_4958	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: bja:bll6612 hypothetical protein.	0.727
Kfla_5830	Kfla_5075	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	0.750
Kfla_5830	Kfla_5829	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: scl:sce6417 ECF subfamily RNA polymerase sigma factor.	0.886
Kfla_5830	Kfla_6234	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	0.726
Kfla_6234	Kfla_5830	Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: psa:PST_0150 probable sigma-70 factor, ECF subfamily.	PFAM: YCII-related; KEGG: scl:sce6416 hypothetical protein.	0.726

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.925

expected number of edges:

46

PPI enrichment p-value:

0.981

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042128

Nitrate assimilation

4 of 16

2.67

3.23

9.14e-07

GO:0034975

Protein folding in endoplasmic reticulum

3 of 9

2.79

2.54

2.14e-05

GO:0043436

Oxoacid metabolic process

6 of 1303

0.93

0.59

0.0164

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050464

Nitrate reductase (NADPH) activity

4 of 4

3.27

4.49

6.87e-09

GO:0043546

Molybdopterin cofactor binding

4 of 10

2.87

4.16

1.96e-08

GO:0030151

Molybdenum ion binding

4 of 15

2.7

3.9

4.74e-08

GO:0071949

FAD binding

6 of 147

1.88

3.2

2.54e-08

GO:0016972

Thiol oxidase activity

2 of 4

2.97

1.69

0.00086

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25710

Nitrate reductase activity

5 of 5

3.27

6.11

6.94e-12

CL:25684

Mixed, incl. Sulfur metabolism, and Protein disulfide isomerase activity

8 of 132

2.05

4.86

2.23e-12

CL:25892

Protein disulfide isomerase activity

3 of 13

2.63

2.54

1.94e-05

CL:25894

Protein disulfide isomerase activity, and ERO1-like superfamily

2 of 8

2.67

1.44

0.0024

CL:23966

Tryptophan synthase activity, and Indole-3-glycerol phosphate synthase

2 of 8

2.67

1.44

0.0024

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

4 of 104

1.86

2.06

3.67e-05

map04141

Protein processing in endoplasmic reticulum

4 of 402

1.27

0.96

0.0035

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

2 of 77

1.69

0.71

0.0415

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

4 of 102

1.87

2.0

5.56e-05

KW-0349

Heme

3 of 97

1.76

1.35

0.0016

KW-1015

Disulfide bond

2 of 58

1.81

0.84

0.0235

KW-0560

Oxidoreductase

3 of 325

1.24

0.68

0.0261

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00970

Oxidoreductase FAD-binding domain

5 of 15

2.79

4.91

6.04e-10

PF03404

Mo-co oxidoreductase dimerisation domain

4 of 9

2.92

4.01

4.10e-08

PF00174

Oxidoreductase molybdopterin binding domain

4 of 10

2.87

3.99

4.10e-08

PF00175

Oxidoreductase NAD-binding domain

4 of 26

2.46

3.19

7.81e-07

PF04137

Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

2 of 2

3.27

1.72

0.00081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008333

Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

5 of 15

2.79

4.7

1.53e-09

IPR008335

Eukaryotic molybdopterin oxidoreductase

4 of 9

2.92

3.79

1.04e-07

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

4 of 9

2.92

3.79

1.04e-07

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

4 of 10

2.87

3.78

1.04e-07

IPR000572

Oxidoreductase, molybdopterin-binding domain

4 of 10

2.87

3.78

1.04e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

5 of 52

2.25

3.67

3.35e-08

Enrichment display settings

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