STRINGSTRING
Agtr1 Agtr1 Scnn1b Scnn1b Qrfp Qrfp Ext2 Ext2 Mc3r Mc3r Agtr2 Agtr2 LOC105989822 LOC105989822 Ace Ace Gna12 Gna12 LOC105994460 LOC105994460 ENSDORP00000027038 ENSDORP00000027038 Slc4a5 Slc4a5 Chrna7 Chrna7 Avpr1a Avpr1a Mecp2 Mecp2 Cartpt Cartpt Adora1 Adora1 Ncf2 Ncf2 Ramp2 Ramp2 Gna11 Gna11 Edn1 Edn1 Pmch Pmch Ptgs1 Ptgs1 F2rl1 F2rl1 Bbs4 Bbs4 Oxt Oxt ENSDORP00000023352 ENSDORP00000023352 Smad3 Smad3 Nox1 Nox1 Nos3 Nos3 F2r F2r Tnni3 Tnni3 Emp2 Emp2 Aoc3 Aoc3 Atp2b2 Atp2b2 Ace3 Ace3 Ier3 Ier3 Ar Ar Atp5pf Atp5pf Pdgfb Pdgfb Gsk3a Gsk3a Atp6ap2 Atp6ap2 Gnaq Gnaq Drd3 Drd3 Olfr78 Olfr78 Kl Kl Adm Adm Cacna1c Cacna1c Abat Abat LOC105994289 LOC105994289 Pik3r1 Pik3r1 Npff Npff Cacna1b Cacna1b Sucnr1 Sucnr1 Npy1r Npy1r Hsd11b2 Hsd11b2 Atp2b1 Atp2b1 Gch1 Gch1 Cyba Cyba ENSDORP00000000697 ENSDORP00000000697 Vegfc Vegfc Edn3 Edn3 Nav2 Nav2 Lrp5 Lrp5 Lnpep Lnpep Uts2r Uts2r Crhr2 Crhr2 Adm2 Adm2 Ncald Ncald Emilin1 Emilin1 Bdkrb1 Bdkrb1 Gucy1a1 Gucy1a1 Abcc9 Abcc9 Acta2 Acta2 Arhgef12 Arhgef12 Ffar3 Ffar3 Ece1 Ece1 Nedd4l Nedd4l Gna13 Gna13 Corin Corin Acvrl1 Acvrl1 Enpep Enpep Asic2 Asic2 Agtrap Agtrap Arhgap42 Arhgap42 Id2 Id2 Rnls Rnls Grip2 Grip2 Hmox1 Hmox1 Ednra Ednra Nppa Nppa Adamts16 Adamts16 Crh Crh Ace2 Ace2 Drd2 Drd2 Rnpep Rnpep Npr3 Npr3 Avpr1b Avpr1b Ddah1 Ddah1 Adipoq Adipoq Snx5 Snx5 LOC105994292 LOC105994292 Gas6 Gas6 Chrm3 Chrm3 Scnn1g Scnn1g Agt Agt Gpr37l1 Gpr37l1 Gja5 Gja5 Ephx2 Ephx2 Ar-2 Ar-2 Ucn Ucn Manf Manf Adra1d Adra1d Klk1 Klk1 Postn Postn Bmpr2 Bmpr2 Nos1 Nos1 Rarres2 Rarres2 Ednrb Ednrb Anpep Anpep Coro2b Coro2b F11r F11r Cnr1 Cnr1 Nampt Nampt Atp1a2 Atp1a2 Rps6ka2 Rps6ka2 Ahr Ahr Oxtr Oxtr Apln Apln Sult1a1 Sult1a1 Kdr Kdr Fshr Fshr Serpinf2 Serpinf2 Lvrn Lvrn Uts2b Uts2b Edn2 Edn2 Adra1a Adra1a Ndst2 Ndst2 Npr1 Npr1 Kcnq1 Kcnq1 Drd5 Drd5 Gnas Gnas Lep Lep Tbxa2r Tbxa2r Kcnk6 Kcnk6 Nisch Nisch Rasl10b Rasl10b Mkks Mkks Pparg Pparg Ren Ren Glp1r Glp1r Prcp Prcp Col1a2 Col1a2 Scpep1 Scpep1 Ptgs2 Ptgs2 Cd34 Cd34 P2rx1 P2rx1 Avpr2 Avpr2 Npy Npy Wnk1 Wnk1 Umod Umod Cpa3 Cpa3 Plcb3 Plcb3 Smtn Smtn Sod2 Sod2 Tac2 Tac2 Atp1a1 Atp1a1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Agtr1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Scnn1bAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (543 aa)
QrfpOrexigenic neuropeptide QRFP. (125 aa)
Ext2Exostosin-2; Belongs to the glycosyltransferase 47 family. (718 aa)
Mc3rMelanocortin receptor 3. (322 aa)
Agtr2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LOC105989822Aminopeptidase. (942 aa)
AceAngiotensin-converting enzyme. (1315 aa)
Gna12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
LOC105994460Renin receptor-like isoform X1. (351 aa)
ENSDORP00000027038annotation not available (365 aa)
Slc4a5Anion exchange protein. (1125 aa)
Chrna7Neuronal acetylcholine receptor subunit alpha-7. (568 aa)
Avpr1aVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
Mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
CartptCocaine- and amphetamine-regulated transcript protein isoform X1. (136 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (327 aa)
Ncf2Neutrophil cytosol factor 2 isoform X1. (526 aa)
Ramp2Receptor activity-modifying protein 2. (100 aa)
Gna11Guanine nucleotide-binding protein subunit alpha-11. (313 aa)
Edn1Endothelin-1-like isoform X1. (202 aa)
Pmchpro-MCH. (165 aa)
Ptgs1Prostaglandin G/H synthase 1. (600 aa)
F2rl1Proteinase-activated receptor 2. (397 aa)
Bbs4Bardet-Biedl syndrome 4 protein isoform X2. (514 aa)
OxtOxytocin-neurophysin 1; Belongs to the vasopressin/oxytocin family. (125 aa)
ENSDORP00000023352annotation not available (88 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Nox1NADPH oxidase 1 isoform X1. (567 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1201 aa)
F2rProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (428 aa)
Tnni3Troponin I, cardiac muscle isoform X2. (211 aa)
Emp2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (168 aa)
Aoc3Amine oxidase; Belongs to the copper/topaquinone oxidase family. (668 aa)
Atp2b2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
Ace3Angiotensin-converting enzyme. (728 aa)
Ier3Radiation-inducible immediate-early gene IEX-1. (156 aa)
ArAndrogen receptor. (397 aa)
Atp5pfATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
Gsk3aGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
Atp6ap2Renin receptor. (347 aa)
GnaqGuanine nucleotide-binding protein G(Q) subunit alpha. (333 aa)
Drd3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
Olfr78Olfactory receptor. (320 aa)
KlKlotho. (1020 aa)
AdmADM. (189 aa)
Cacna1cVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1179 aa)
Abat4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
LOC105994289Kallikrein-1-like isoform X2; Belongs to the peptidase S1 family. (240 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Npffpro-FMRFamide-related neuropeptide FF. (109 aa)
Cacna1bVoltage-dependent N-type calcium channel subunit alpha-1B. (2037 aa)
Sucnr1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (320 aa)
Npy1rNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2. (405 aa)
Atp2b1Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1019 aa)
Gch1GTP cyclohydrolase 1. (250 aa)
CybaCytochrome b-245 light chain. (176 aa)
ENSDORP00000000697annotation not available (678 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
Edn3Endothelin-3. (206 aa)
Nav2Neuron navigator 2. (2351 aa)
Lrp5Low-density lipoprotein receptor-related protein 5. (1616 aa)
LnpepLeucyl-cystinyl aminopeptidase isoform X1. (1023 aa)
Uts2rUrotensin-2 receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa)
Crhr2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (411 aa)
Adm2ADM2. (143 aa)
NcaldNeurocalcin-delta. (193 aa)
Emilin1EMILIN-1. (1015 aa)
Bdkrb1B1 bradykinin receptor. (326 aa)
Gucy1a1Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
Abcc9ATP-binding cassette sub-family C member 9. (1521 aa)
Acta2Actin, aortic smooth muscle. (377 aa)
Arhgef12Rho guanine nucleotide exchange factor 12. (1511 aa)
Ffar3Free fatty acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (316 aa)
Ece1Endothelin-converting enzyme 1. (724 aa)
Nedd4lE3 ubiquitin-protein ligase NEDD4-like isoform X1. (984 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (372 aa)
CorinAtrial natriuretic peptide-converting enzyme. (1032 aa)
Acvrl1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
EnpepAminopeptidase. (952 aa)
Asic2Acid-sensing ion channel 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (512 aa)
AgtrapType-1 angiotensin II receptor-associated protein. (165 aa)
Arhgap42Rho GTPase-activating protein 42. (825 aa)
Id2DNA-binding protein inhibitor ID-2. (116 aa)
RnlsRenalase isoform X1. (204 aa)
Grip2Glutamate receptor-interacting protein 2. (1042 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (285 aa)
EdnraEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
NppaNatriuretic peptides A. (153 aa)
Adamts16A disintegrin and metalloproteinase with thrombospondin motifs 16. (783 aa)
CrhCorticoliberin. (188 aa)
Ace2Angiotensin-converting enzyme. (805 aa)
Drd2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (443 aa)
RnpepLOW QUALITY PROTEIN: aminopeptidase B. (643 aa)
Npr3Atrial natriuretic peptide receptor 3 isoform X1. (541 aa)
Avpr1bVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
Ddah1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1. (220 aa)
AdipoqAdiponectin. (251 aa)
Snx5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
LOC105994292Kallikrein-2-like; Belongs to the peptidase S1 family. (208 aa)
Gas6Growth arrest-specific protein 6. (660 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
Scnn1gAmiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (652 aa)
AgtAngiotensinogen; Belongs to the serpin family. (473 aa)
Gpr37l1Prosaposin receptor GPR37L1. (481 aa)
Gja5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (310 aa)
Ephx2Bifunctional epoxide hydrolase 2. (555 aa)
Ar-2Androgen receptor. (495 aa)
UcnUrocortin. (130 aa)
ManfMesencephalic astrocyte-derived neurotrophic factor. (171 aa)
Adra1dalpha-1D adrenergic receptor. (575 aa)
Klk1Kallikrein-1; Belongs to the peptidase S1 family. (245 aa)
PostnPeriostin. (672 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (933 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1423 aa)
Rarres2Retinoic acid receptor responder protein 2. (160 aa)
EdnrbEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (444 aa)
AnpepAminopeptidase. (924 aa)
Coro2bCoronin; Belongs to the WD repeat coronin family. (480 aa)
F11rJunctional adhesion molecule A. (293 aa)
Cnr1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (471 aa)
NamptNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
Atp1a2Sodium/potassium-transporting ATPase subunit alpha. (1046 aa)
Rps6ka2Non-specific serine/threonine protein kinase. (705 aa)
AhrAryl hydrocarbon receptor. (807 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (375 aa)
AplnApelin. (77 aa)
Sult1a1Sulfotransferase; Belongs to the sulfotransferase 1 family. (282 aa)
KdrVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1352 aa)
FshrFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (700 aa)
Serpinf2Alpha-2-antiplasmin; Belongs to the serpin family. (411 aa)
LvrnAminopeptidase. (759 aa)
Uts2burotensin-2B. (116 aa)
Edn2Endothelin-2 isoform X1. (178 aa)
Adra1aalpha-1A adrenergic receptor isoform X1. (467 aa)
Ndst2Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2. (883 aa)
Npr1Guanylate cyclase. (1060 aa)
Kcnq1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (622 aa)
Drd5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
GnasGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (394 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Tbxa2rCactin-like. (354 aa)
Kcnk6Potassium channel subfamily K member. (313 aa)
NischNischarin isoform X2. (1516 aa)
Rasl10bRas-like protein family member 10B. (293 aa)
MkksMcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (569 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
RenRenin; Belongs to the peptidase A1 family. (403 aa)
Glp1rGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (331 aa)
PrcpLysosomal Pro-X carboxypeptidase. (307 aa)
Col1a2Collagen alpha-2(I) chain. (1364 aa)
Scpep1Carboxypeptidase; Belongs to the peptidase S10 family. (452 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
Cd34Hematopoietic progenitor cell antigen CD34 isoform X2. (380 aa)
P2rx1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
Avpr2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
NpyPro-neuropeptide Y. (97 aa)
Wnk1Serine/threonine-protein kinase WNK1. (2110 aa)
UmodUromodulin. (588 aa)
Cpa3Mast cell carboxypeptidase A. (416 aa)
Plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
SmtnSmoothelin isoform X2. (939 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
Tac2Tachykinin-3. (120 aa)
Atp1a1Sodium/potassium-transporting ATPase subunit alpha. (1024 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: medium (44%) [HD]