(42 nodes) Regulation of calcium ion-dependent exocytosis network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pou5f1	POU domain protein. (360 aa)
	ENSDORP00000009467	annotation not available (260 aa)
	Doc2b	Double C2-like domain-containing protein beta. (287 aa)
	ENSDORP00000026363	annotation not available (164 aa)
	Trim9	E3 ubiquitin-protein ligase TRIM9 isoform X1. (790 aa)
	Baiap3	BAI1-associated protein 3. (1028 aa)
	Rab3gap1	Rab3 GTPase-activating protein catalytic subunit. (978 aa)
	Cdk5	Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
	Syt13	Synaptotagmin-13. (392 aa)
	Cacna1i	Voltage-dependent T-type calcium channel subunit alpha-1I. (2201 aa)
	Zp3	Zona pellucida sperm-binding protein 3. (416 aa)
	Syt1	Synaptotagmin-1 isoform X1. (422 aa)
	Doc2a	Double C2-like domain-containing protein. (405 aa)
	Rph3al	Rab effector Noc2. (302 aa)
	Syt17	Synaptotagmin-17. (407 aa)
	Syt5	Synaptotagmin-5. (387 aa)
	Syt6	LOW QUALITY PROTEIN: synaptotagmin-6. (491 aa)
	Syt4	Synaptotagmin-4. (425 aa)
	Stxbp1	Syntaxin-binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
	Kcnb1	Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (850 aa)
	Cdk5r2	Cyclin-dependent kinase 5 activator. (96 aa)
	Cbarp	Protein Dos. (713 aa)
	Atp2a2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (986 aa)
	Syt8	Synaptotagmin-8. (387 aa)
	Syt11	Synaptotagmin-11. (431 aa)
	Cadps	Calcium-dependent secretion activator 1 isoform X1. (1367 aa)
	Syt9	Synaptotagmin-9. (513 aa)
	Syt3	Synaptotagmin-3. (588 aa)
	Rap1b	Ras-related protein Rap-1b. (184 aa)
	Hyal3	Hyaluronidase. (418 aa)
	Rest	RE1-silencing transcription factor isoform X2. (329 aa)
	Syt12	Synaptotagmin-12. (421 aa)
	Stxbp3	Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (591 aa)
	Cacna1a	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (2254 aa)
	Cacna1h	Voltage-dependent T-type calcium channel subunit alpha-1H. (2166 aa)
	Rph3a	rabphilin-3A isoform X1. (672 aa)
	Syt7	Synaptotagmin 7. (556 aa)
	Doc2g	Double C2-like domain-containing protein gamma. (327 aa)
	Syt10	Synaptotagmin-10. (453 aa)
	Stx1a	syntaxin-1A; Belongs to the syntaxin family. (288 aa)
	Syt2	Synaptotagmin-2. (423 aa)
	Cacna1g	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2385 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cacna1a	Cacna1g	ENSDORP00000021703	ENSDORP00000008577	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.893
Cacna1a	Cacna1h	ENSDORP00000021703	ENSDORP00000021896	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent T-type calcium channel subunit alpha-1H.	0.799
Cacna1a	Cacna1i	ENSDORP00000021703	ENSDORP00000004757	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent T-type calcium channel subunit alpha-1I.	0.813
Cacna1a	Stx1a	ENSDORP00000021703	ENSDORP00000001027	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	syntaxin-1A; Belongs to the syntaxin family.	0.845
Cacna1a	Syt1	ENSDORP00000021703	ENSDORP00000003483	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Synaptotagmin-1 isoform X1.	0.502
Cacna1g	Cacna1a	ENSDORP00000008577	ENSDORP00000021703	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	0.893
Cacna1g	Cacna1h	ENSDORP00000008577	ENSDORP00000021896	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent T-type calcium channel subunit alpha-1H.	0.911
Cacna1g	Cacna1i	ENSDORP00000008577	ENSDORP00000004757	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent T-type calcium channel subunit alpha-1I.	0.922
Cacna1h	Cacna1a	ENSDORP00000021896	ENSDORP00000021703	Voltage-dependent T-type calcium channel subunit alpha-1H.	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	0.799
Cacna1h	Cacna1g	ENSDORP00000021896	ENSDORP00000008577	Voltage-dependent T-type calcium channel subunit alpha-1H.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.911
Cacna1h	Cacna1i	ENSDORP00000021896	ENSDORP00000004757	Voltage-dependent T-type calcium channel subunit alpha-1H.	Voltage-dependent T-type calcium channel subunit alpha-1I.	0.938
Cacna1i	Cacna1a	ENSDORP00000004757	ENSDORP00000021703	Voltage-dependent T-type calcium channel subunit alpha-1I.	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	0.813
Cacna1i	Cacna1g	ENSDORP00000004757	ENSDORP00000008577	Voltage-dependent T-type calcium channel subunit alpha-1I.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.922
Cacna1i	Cacna1h	ENSDORP00000004757	ENSDORP00000021896	Voltage-dependent T-type calcium channel subunit alpha-1I.	Voltage-dependent T-type calcium channel subunit alpha-1H.	0.938
Cdk5	Cdk5r2	ENSDORP00000006134	ENSDORP00000017013	Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.992
Cdk5r2	Cdk5	ENSDORP00000017013	ENSDORP00000006134	Cyclin-dependent kinase 5 activator.	Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily.	0.992
Doc2a	Rph3al	ENSDORP00000002882	ENSDORP00000002705	Double C2-like domain-containing protein.	Rab effector Noc2.	0.528
Doc2b	Rph3al	ENSDORP00000027445	ENSDORP00000002705	Double C2-like domain-containing protein beta.	Rab effector Noc2.	0.911
Doc2g	Rph3al	ENSDORP00000023150	ENSDORP00000002705	Double C2-like domain-containing protein gamma.	Rab effector Noc2.	0.448
Hyal3	Zp3	ENSDORP00000019048	ENSDORP00000004512	Hyaluronidase.	Zona pellucida sperm-binding protein 3.	0.506