(42 nodes) Midbrain development network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Phox2a	Paired mesoderm homeobox protein 2A. (282 aa)
	Tal2	T-cell acute lymphocytic leukemia protein 2. (108 aa)
	Uchl5	Ubiquitin carboxyl-terminal hydrolase. (293 aa)
	Lmx1a	LIM homeobox transcription factor 1-alpha. (382 aa)
	Ryk	Tyrosine-protein kinase RYK isoform X1. (475 aa)
	Rac1	Ras-related C3 botulinum toxin substrate 1. (187 aa)
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	Tfap2d	Transcription factor AP-2-delta. (454 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (1602 aa)
	Smad9	Mothers against decapentaplegic homolog. (430 aa)
	Sos1	Son of sevenless homolog 1. (1301 aa)
	LOC105988171	Homeobox protein OTX2 pseudogene. (269 aa)
	Ndst1	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1. (882 aa)
	Fgfr2	Fibroblast growth factor receptor. (819 aa)
	Wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	Pitx3	Homeobox protein. (303 aa)
	En1	Homeobox protein engrailed-like. (140 aa)
	En2	Homeobox protein engrailed-like. (185 aa)
	Fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
	Barhl1	barH-like 1 homeobox protein. (168 aa)
	Uqcrq	Cytochrome b-c1 complex subunit 8. (82 aa)
	ENSDORP00000020585	annotation not available (80 aa)
	Dlg5	Disks large homolog 5; Belongs to the MAGUK family. (263 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	Foxb1	Forkhead box protein B1. (325 aa)
	Cxcr2	C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	Hes1	Transcription factor HES-1. (279 aa)
	Fgfr1	Fibroblast growth factor receptor. (822 aa)
	Otx1	Homeobox protein OTX1. (354 aa)
	Fzd3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	Otx2	Homeobox protein OTX2 isoform X1. (297 aa)
	ENSDORP00000027373	annotation not available (156 aa)
	LOC106002055	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (160 aa)
	Fzd6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	Kdm2b	Lysine-specific demethylase 2B isoform X2. (704 aa)
	Kat2a	Histone acetyltransferase KAT2A isoform X1. (829 aa)
	Wls	Protein wntless homolog. (541 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	Smad1	Mothers against decapentaplegic homolog. (465 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (47 aa)
	Msx1	Homeobox protein MSX-1. (196 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dlg5	ENSDORP00000020585	ENSDORP00000021888	ENSDORP00000020585	Disks large homolog 5; Belongs to the MAGUK family.	annotation not available	0.479
Dlg5	Rac1	ENSDORP00000021888	ENSDORP00000013529	Disks large homolog 5; Belongs to the MAGUK family.	Ras-related C3 botulinum toxin substrate 1.	0.515
ENSDORP00000020585	Dlg5	ENSDORP00000020585	ENSDORP00000021888	annotation not available	Disks large homolog 5; Belongs to the MAGUK family.	0.479
ENSDORP00000020585	Fgfr1	ENSDORP00000020585	ENSDORP00000023825	annotation not available	Fibroblast growth factor receptor.	0.823
ENSDORP00000020585	Fgfr2	ENSDORP00000020585	ENSDORP00000016679	annotation not available	Fibroblast growth factor receptor.	0.680
ENSDORP00000020585	Fgfr3	ENSDORP00000020585	ENSDORP00000009121	annotation not available	Fibroblast growth factor receptor 3.	0.512
ENSDORP00000020585	Fzd3	ENSDORP00000020585	ENSDORP00000024892	annotation not available	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.652
ENSDORP00000020585	Fzd6	ENSDORP00000020585	ENSDORP00000005183	annotation not available	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.654
ENSDORP00000020585	Kat2a	ENSDORP00000020585	ENSDORP00000006387	annotation not available	Histone acetyltransferase KAT2A isoform X1.	0.562
ENSDORP00000020585	LOC106002055	ENSDORP00000020585	ENSDORP00000003519	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.829
ENSDORP00000020585	Lrp6	ENSDORP00000020585	ENSDORP00000002940	annotation not available	Low-density lipoprotein receptor-related protein 6.	0.850
ENSDORP00000020585	Pitx3	ENSDORP00000020585	ENSDORP00000017227	annotation not available	Homeobox protein.	0.556
ENSDORP00000020585	Rac1	ENSDORP00000020585	ENSDORP00000013529	annotation not available	Ras-related C3 botulinum toxin substrate 1.	0.748
ENSDORP00000020585	Smad1	ENSDORP00000020585	ENSDORP00000007570	annotation not available	Mothers against decapentaplegic homolog.	0.709
ENSDORP00000020585	Smad9	ENSDORP00000020585	ENSDORP00000002370	annotation not available	Mothers against decapentaplegic homolog.	0.596
ENSDORP00000020585	Wnt1	ENSDORP00000020585	ENSDORP00000007249	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.867
ENSDORP00000020585	Wnt2	ENSDORP00000020585	ENSDORP00000015274	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.806
ENSDORP00000020585	Wnt3	ENSDORP00000020585	ENSDORP00000017152	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.774
ENSDORP00000020585	Wnt5a	ENSDORP00000020585	ENSDORP00000022201	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.806
ENSDORP00000020585	Wnt9b	ENSDORP00000020585	ENSDORP00000006055	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.600