STRINGSTRING
ENSDORP00000020585 ENSDORP00000020585 Ptpn11 Ptpn11 Gli2 Gli2 Dab1 Dab1 Ophn1 Ophn1 Hnf1b Hnf1b LOC106001615 LOC106001615 Psen1 Psen1 Rora Rora Bcl2 Bcl2 Lhx5 Lhx5 LOC105988171 LOC105988171 Smad9 Smad9 Smarca4 Smarca4 Gabrb3 Gabrb3 Sec24b Sec24b Lrp6 Lrp6 Serpine2 Serpine2 Ncstn Ncstn Sstr2 Sstr2 Cd3e Cd3e Atf2 Atf2 Aars1 Aars1 Ttll1 Ttll1 Nfib Nfib Cntn1 Cntn1 Atic Atic Lrrc1 Lrrc1 Sdf4 Sdf4 Tbr1 Tbr1 Ptbp2 Ptbp2 Phox2a Phox2a Gba Gba Grid2 Grid2 Gart Gart Aldh1a2 Aldh1a2 Ephb2 Ephb2 Pou4f1 Pou4f1 Skor2 Skor2 Abl2 Abl2 Kcnc1 Kcnc1 Klhl4 Klhl4 Lmx1a Lmx1a Klhl1 Klhl1 Ogdh Ogdh Clp1 Clp1 Rbfox2 Rbfox2 Sstr1 Sstr1 Sema4c Sema4c Herc1 Herc1 Cend1 Cend1 Gdf10 Gdf10 Mafb Mafb Zbtb18 Zbtb18 Usp9x Usp9x Klhl5 Klhl5 Sptbn2 Sptbn2 Cdk5r2 Cdk5r2 Myo16 Myo16 Foxa2 Foxa2 Mtpn Mtpn Flna Flna En1 En1 En2 En2 Nav2 Nav2 Scrib Scrib Samd4b Samd4b Atp7a Atp7a Dixdc1 Dixdc1 Nrxn1 Nrxn1 Fgf2 Fgf2 Lpar1 Lpar1 Znf423 Znf423 Lhx1 Lhx1 Nr2c2 Nr2c2 Foxp2 Foxp2 Gli1 Gli1 Pcnt Pcnt Sez6l Sez6l Wls Wls Prox1 Prox1 Lef1 Lef1 Wnt1 Wnt1 Itgb1 Itgb1 Hoxb1 Hoxb1 Hoxb2 Hoxb2 Hoxb3 Hoxb3 Smad1 Smad1 Cul5 Cul5 Grin1 Grin1 Fzd4 Fzd4 Hes1 Hes1 Socs7 Socs7 Atp1b2 Atp1b2 Sez6l2 Sez6l2 Kcne1 Kcne1 Atg7 Atg7 Trp53 Trp53 Agtpbp1 Agtpbp1 Znf365 Znf365 Ephb1 Ephb1 Insr Insr Otx1 Otx1 Ldb1 Ldb1 Cbln1 Cbln1 LOC105996454 LOC105996454 Hnrnpd Hnrnpd Rnf7 Rnf7 Dfnb31 Dfnb31 LOC105994487 LOC105994487 Bmp5 Bmp5 Pfdn1 Pfdn1 Rpgrip1l Rpgrip1l Mecp2 Mecp2 Nog Nog Neurod1 Neurod1 Otx2 Otx2 ENSDORP00000026513 ENSDORP00000026513 ENSDORP00000026600 ENSDORP00000026600 Ttc21b Ttc21b Atf5 Atf5 Mdk Mdk ENSDORP00000027373 ENSDORP00000027373 Agtr2 Agtr2 Atxn2 Atxn2 Faim2 Faim2 Egr2 Egr2 Pdss2 Pdss2 Kndc1 Kndc1 Gata2 Gata2 Neurod2 Neurod2 Ulk1 Ulk1 ENSDORP00000019506 ENSDORP00000019506 Uqcrq Uqcrq Ttbk2 Ttbk2 Pax6 Pax6 Ptf1a Ptf1a Psmg1 Psmg1 Crkl Crkl Cdk5r1 Cdk5r1 Rere Rere Ezh2 Ezh2 Tmbim7 Tmbim7 Gnpat Gnpat Cacna1a Cacna1a Nanos1 Nanos1 Gbx2 Gbx2 Cbs Cbs Dlc1 Dlc1 Crk Crk Gsx2 Gsx2 ENSDORP00000000697 ENSDORP00000000697 Sez6 Sez6 Map2k1 Map2k1 Igf1r Igf1r Myh10 Myh10 Arcn1 Arcn1 Smo Smo B4galt2 B4galt2 Slc4a7 Slc4a7 Atrn Atrn Hap1 Hap1 Ahi1 Ahi1 Slc25a46 Slc25a46 Xrcc1 Xrcc1 Arl13b Arl13b Ptprs Ptprs Hoxa1 Hoxa1 Hoxa2 Hoxa2 Naglu Naglu Cdk5 Cdk5 Plxna2 Plxna2 Coq8b Coq8b Kdm2b Kdm2b Kat2a Kat2a Sstr3 Sstr3 Abat Abat Phox2b Phox2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSDORP00000020585annotation not available (80 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Gli2Zinc finger protein GLI2. (1549 aa)
Dab1Disabled homolog 1 isoform X1. (555 aa)
Ophn1Oligophrenin-1. (782 aa)
Hnf1bHepatocyte nuclear factor 1-beta isoform X1. (558 aa)
LOC106001615Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (264 aa)
Psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
RoraNuclear receptor ROR-alpha. (523 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Lhx5LIM/homeobox protein Lhx5. (324 aa)
LOC105988171Homeobox protein OTX2 pseudogene. (269 aa)
Smad9Mothers against decapentaplegic homolog. (430 aa)
Smarca4Transcription activator BRG1. (1513 aa)
Gabrb3Gamma-aminobutyric acid receptor subunit beta-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (495 aa)
Sec24bLOW QUALITY PROTEIN: protein transport protein Sec24B. (1232 aa)
Lrp6Low-density lipoprotein receptor-related protein 6. (1602 aa)
Serpine2Glia-derived nexin; Belongs to the serpin family. (404 aa)
NcstnNicastrin. (698 aa)
Sstr2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (343 aa)
Cd3eT-cell surface glycoprotein CD3 epsilon chain. (190 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
Aars1alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
Ttll1Probable tubulin polyglutamylase TTLL1. (423 aa)
NfibNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
Cntn1Contactin-1 isoform X1. (1018 aa)
AticBifunctional purine biosynthesis protein PURH. (592 aa)
Lrrc1Leucine-rich repeat-containing protein 1. (419 aa)
Sdf445 kDa calcium-binding protein. (190 aa)
Tbr1T-box brain protein 1. (682 aa)
Ptbp2Polypyrimidine tract-binding protein 2 isoform X3. (542 aa)
Phox2aPaired mesoderm homeobox protein 2A. (282 aa)
GbaGlucosylceramidase. (515 aa)
Grid2Glutamate receptor ionotropic, delta-2 isoform X1. (977 aa)
GartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (849 aa)
Aldh1a2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (474 aa)
Ephb2Ephrin type-B receptor 2 isoform X2. (1018 aa)
Pou4f1POU domain, class 4, transcription factor 1. (243 aa)
Skor2SKI family transcriptional corepressor 2. (675 aa)
Abl2Tyrosine-protein kinase. (1132 aa)
Kcnc1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
Klhl4Kelch-like protein 4 isoform X1. (716 aa)
Lmx1aLIM homeobox transcription factor 1-alpha. (382 aa)
Klhl1Kelch-like protein 1 isoform X1. (751 aa)
Ogdh2-oxoglutarate dehydrogenase, mitochondrial isoform X1. (1023 aa)
Clp1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
Rbfox2RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (368 aa)
Sstr1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
Sema4csemaphorin-4C; Belongs to the semaphorin family. (831 aa)
Herc1Probable E3 ubiquitin-protein ligase HERC1. (4769 aa)
Cend1Cell cycle exit and neuronal differentiation protein 1. (147 aa)
Gdf10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (476 aa)
MafbTranscription factor MafB. (322 aa)
Zbtb18Zinc finger and BTB domain-containing protein 18. (128 aa)
Usp9xProbable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2317 aa)
Klhl5Kelch-like protein 5 isoform X1. (708 aa)
Sptbn2Spectrin beta chain; Belongs to the spectrin family. (2383 aa)
Cdk5r2Cyclin-dependent kinase 5 activator. (96 aa)
Myo16Unconventional myosin-XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1706 aa)
Foxa2Hepatocyte nuclear factor 3-beta. (465 aa)
MtpnMyotrophin. (118 aa)
Flnafilamin-A isoform X1. (2647 aa)
En1Homeobox protein engrailed-like. (140 aa)
En2Homeobox protein engrailed-like. (185 aa)
Nav2Neuron navigator 2. (2351 aa)
ScribProtein scribble homolog. (1608 aa)
Samd4bProtein Smaug homolog 2. (674 aa)
Atp7aCopper-transporting ATPase 1. (1488 aa)
Dixdc1Dixin isoform X1. (711 aa)
Nrxn1Neurexin-1-beta isoform X1. (1515 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
Znf423Zinc finger protein 423 isoform X1. (1294 aa)
Lhx1LIM/homeobox protein Lhx1. (406 aa)
Nr2c2Nuclear receptor subfamily 2 group C member 2. (629 aa)
Foxp2Forkhead box protein P2 isoform X1. (736 aa)
Gli1Zinc finger protein GLI1 isoform X1. (1107 aa)
PcntPericentrin. (2788 aa)
Sez6lSeizure 6-like protein. (787 aa)
WlsProtein wntless homolog. (541 aa)
Prox1Prospero homeobox protein 1. (737 aa)
Lef1Lymphoid enhancer-binding factor 1. (370 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Itgb1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
Hoxb1Homeobox protein Hox-B1. (302 aa)
Hoxb2Homeobox protein Hox-B2. (355 aa)
Hoxb3Homeobox protein Hox-B3. (436 aa)
Smad1Mothers against decapentaplegic homolog. (465 aa)
Cul5Cullin-5; Belongs to the cullin family. (751 aa)
Grin1LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1. (926 aa)
Fzd4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
Hes1Transcription factor HES-1. (279 aa)
Socs7Suppressor of cytokine signaling 7. (580 aa)
Atp1b2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
Sez6l2Seizure 6-like protein 2 isoform X1. (923 aa)
Kcne1Potassium voltage-gated channel subfamily E member 1. (150 aa)
Atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
Agtpbp1LOW QUALITY PROTEIN: cytosolic carboxypeptidase 1. (1118 aa)
Znf365Protein ZNF365. (401 aa)
Ephb1Ephrin type-B receptor 1. (836 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Otx1Homeobox protein OTX1. (354 aa)
Ldb1LIM domain-binding protein 1 isoform X1. (411 aa)
Cbln1Cerebellin-1. (193 aa)
LOC105996454Low affinity immunoglobulin gamma Fc region receptor II-like. (311 aa)
HnrnpdHeterogeneous nuclear ribonucleoprotein D0. (310 aa)
Rnf7RING-box protein 2 isoform X1. (113 aa)
Dfnb31Whirlin. (465 aa)
LOC105994487Ephrin type-B receptor 1-like. (304 aa)
Bmp5Bone morphogenetic protein 5 isoform X1. (454 aa)
Pfdn1Prefoldin subunit 1. (122 aa)
Rpgrip1lProtein fantom. (1283 aa)
Mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
NogNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (233 aa)
Neurod1Neurogenic differentiation factor. (356 aa)
Otx2Homeobox protein OTX2 isoform X1. (297 aa)
ENSDORP00000026513annotation not available (164 aa)
ENSDORP00000026600annotation not available (64 aa)
Ttc21bTetratricopeptide repeat protein 21B isoform X1. (1314 aa)
Atf5Cyclic AMP-dependent transcription factor ATF-5. (284 aa)
MdkMidkine. (159 aa)
ENSDORP00000027373annotation not available (156 aa)
Agtr2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
Atxn2Ataxin-2. (1047 aa)
Faim2Protein lifeguard 2 isoform X1; Belongs to the BI1 family. (316 aa)
Egr2E3 SUMO-protein ligase EGR2. (72 aa)
Pdss2Decaprenyl-diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (400 aa)
Kndc1Protein very KIND. (1531 aa)
Gata2Endothelial transcription factor GATA-2. (478 aa)
Neurod2Neurogenic differentiation factor. (383 aa)
Ulk1Serine/threonine-protein kinase ULK1. (1012 aa)
ENSDORP00000019506annotation not available (69 aa)
UqcrqCytochrome b-c1 complex subunit 8. (82 aa)
Ttbk2Tau-tubulin kinase 2. (436 aa)
Pax6Paired box protein Pax-6 isoform X2. (561 aa)
Ptf1aPancreas transcription factor 1 subunit alpha. (262 aa)
Psmg1Proteasome assembly chaperone 1 isoform X1. (286 aa)
CrklCrk-like protein. (303 aa)
Cdk5r1Cyclin-dependent kinase 5 activator. (310 aa)
RereArginine-glutamic acid dipeptide repeats protein. (193 aa)
Ezh2Histone-lysine N-methyltransferase EZH2 isoform X1. (746 aa)
Tmbim7Uncharacterized protein LOC105992903. (281 aa)
GnpatDihydroxyacetone phosphate acyltransferase. (663 aa)
Cacna1aVoltage-dependent P/Q-type calcium channel subunit alpha-1A. (2254 aa)
Nanos1Nanos homolog 1; Belongs to the nanos family. (194 aa)
Gbx2Homeobox protein GBX-2. (302 aa)
CbsCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (561 aa)
Dlc1Rho GTPase-activating protein 7 isoform X1. (1125 aa)
CrkAdapter molecule crk. (304 aa)
Gsx2LOW QUALITY PROTEIN: GS homeobox 2. (303 aa)
ENSDORP00000000697annotation not available (678 aa)
Sez6Seizure protein 6 homolog isoform X1. (995 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Myh10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
Arcn1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (511 aa)
SmoSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
B4galt2Beta-1,4-galactosyltransferase 2. (369 aa)
Slc4a7Anion exchange protein. (1202 aa)
AtrnAttractin isoform X1. (1422 aa)
Hap1Huntingtin-associated protein 1. (580 aa)
Ahi1Jouberin isoform X3. (1053 aa)
Slc25a46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (416 aa)
Xrcc1DNA repair protein XRCC1. (642 aa)
Arl13bADP-ribosylation factor-like protein 13B isoform X1. (432 aa)
PtprsReceptor-type tyrosine-protein phosphatase S. (1430 aa)
Hoxa1Homeobox protein Hox-A1 isoform X1. (338 aa)
Hoxa2Homeobox protein Hox-A2. (374 aa)
Naglualpha-N-acetylglucosaminidase. (743 aa)
Cdk5Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
Plxna2plexin-A2. (1891 aa)
Coq8baarF domain-containing protein kinase 4. (409 aa)
Kdm2bLysine-specific demethylase 2B isoform X2. (704 aa)
Kat2aHistone acetyltransferase KAT2A isoform X1. (829 aa)
Sstr3Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (429 aa)
Abat4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
Phox2bPaired mesoderm homeobox protein 2B. (300 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (12%) [HD]