(44 nodes) Regulation of cell adhesion mediated by integrin network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Hrg	Histidine-rich glycoprotein. (520 aa)
	Snai2	Zinc finger protein SNAI2. (261 aa)
	Plau	Urokinase-type plasminogen activator. (425 aa)
	Cxcl13	C-X-C motif chemokine 13. (110 aa)
	Ptk2	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
	Crkl	Crk-like protein. (303 aa)
	Cd24a	CD24a antigen. (77 aa)
	Crk	Adapter molecule crk. (304 aa)
	Acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	P2ry12	p2Y purinoceptor 12. (341 aa)
	Swap70	Switch-associated protein 70. (526 aa)
	Ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1115 aa)
	Lif	Leukemia inhibitory factor. (202 aa)
	Podxl	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (287 aa)
	Efna1	ephrin-A1; Belongs to the ephrin family. (203 aa)
	Epha2	Ephrin type-A receptor 2 isoform X2. (976 aa)
	Itgb3	Integrin beta; Belongs to the integrin beta chain family. (766 aa)
	Cd3e	T-cell surface glycoprotein CD3 epsilon chain. (190 aa)
	Tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
	Fermt1	Fermitin family homolog 1. (677 aa)
	Ada	Adenosine deaminase isoform X2. (373 aa)
	Def6	Differentially expressed in FDCP 6 homolog. (631 aa)
	Nexmif	Protein KIAA2022 homolog. (1492 aa)
	Ccl21	C-C motif chemokine 21. (134 aa)
	Cib1	Calcium and integrin-binding protein 1. (113 aa)
	Cyp1b1	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (547 aa)
	Ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
	Ift74	Intraflagellar transport protein 74 homolog. (557 aa)
	Serpine1	Plasminogen activator inhibitor 1 isoform X2; Belongs to the serpin family. (401 aa)
	Tesc	Calcineurin B homologous protein 3. (213 aa)
	Muc1	Mucin-1. (381 aa)
	Jam3	LOW QUALITY PROTEIN: junctional adhesion molecule C. (310 aa)
	Nckap1l	Nck-associated protein 1-like. (1029 aa)
	Wnk1	Serine/threonine-protein kinase WNK1. (2110 aa)
	Dpp4	Dipeptidyl peptidase 4 isoform X2; Belongs to the peptidase S9B family. (761 aa)
	Fermt3	Fermitin family homolog 3. (664 aa)
	Adam9	Disintegrin and metalloproteinase domain-containing protein 9. (792 aa)
	Ptpn6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	Lyn	Tyrosine-protein kinase. (512 aa)
	Syk	Tyrosine-protein kinase. (633 aa)
	Lrrc45	Leucine-rich repeat-containing protein 45. (631 aa)
	Itgb1bp1	Integrin beta-1-binding protein 1. (200 aa)
	Epha8	Ephrin type-A receptor 8. (981 aa)
	Lpxn	Leupaxin; Belongs to the paxillin family. (386 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ada	Dpp4	ENSDORP00000004493	ENSDORP00000001780	Adenosine deaminase isoform X2.	Dipeptidyl peptidase 4 isoform X2; Belongs to the peptidase S9B family.	0.965
Adam9	Efna1	ENSDORP00000001428	ENSDORP00000027474	Disintegrin and metalloproteinase domain-containing protein 9.	ephrin-A1; Belongs to the ephrin family.	0.412
Adam9	Epha2	ENSDORP00000001428	ENSDORP00000016743	Disintegrin and metalloproteinase domain-containing protein 9.	Ephrin type-A receptor 2 isoform X2.	0.440
Ccl21	Cxcl13	ENSDORP00000002350	ENSDORP00000019604	C-C motif chemokine 21.	C-X-C motif chemokine 13.	0.866
Cd24a	Lyn	ENSDORP00000021542	ENSDORP00000000698	CD24a antigen.	Tyrosine-protein kinase.	0.404
Cd3e	Lyn	ENSDORP00000003211	ENSDORP00000000698	T-cell surface glycoprotein CD3 epsilon chain.	Tyrosine-protein kinase.	0.697
Cd3e	Ptpn11	ENSDORP00000003211	ENSDORP00000007760	T-cell surface glycoprotein CD3 epsilon chain.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.694
Cd3e	Ptpn6	ENSDORP00000003211	ENSDORP00000001109	T-cell surface glycoprotein CD3 epsilon chain.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.707
Cd3e	Syk	ENSDORP00000003211	ENSDORP00000000466	T-cell surface glycoprotein CD3 epsilon chain.	Tyrosine-protein kinase.	0.990
Crk	Crkl	ENSDORP00000022183	ENSDORP00000021103	Adapter molecule crk.	Crk-like protein.	0.907
Crk	Epha2	ENSDORP00000022183	ENSDORP00000016743	Adapter molecule crk.	Ephrin type-A receptor 2 isoform X2.	0.906
Crk	Epha8	ENSDORP00000022183	ENSDORP00000013675	Adapter molecule crk.	Ephrin type-A receptor 8.	0.559
Crk	Ift74	ENSDORP00000022183	ENSDORP00000008416	Adapter molecule crk.	Intraflagellar transport protein 74 homolog.	0.432
Crk	Itgb3	ENSDORP00000022183	ENSDORP00000015441	Adapter molecule crk.	Integrin beta; Belongs to the integrin beta chain family.	0.866
Crk	Lpxn	ENSDORP00000022183	ENSDORP00000017315	Adapter molecule crk.	Leupaxin; Belongs to the paxillin family.	0.943
Crk	Lyn	ENSDORP00000022183	ENSDORP00000000698	Adapter molecule crk.	Tyrosine-protein kinase.	0.721
Crk	Nckap1l	ENSDORP00000022183	ENSDORP00000001987	Adapter molecule crk.	Nck-associated protein 1-like.	0.631
Crk	Ptk2	ENSDORP00000022183	ENSDORP00000019796	Adapter molecule crk.	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.979
Crk	Ptpn11	ENSDORP00000022183	ENSDORP00000007760	Adapter molecule crk.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.467
Crk	Ptpn6	ENSDORP00000022183	ENSDORP00000001109	Adapter molecule crk.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.439