(12 nodes) Nerve growth factor signaling pathway network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ntf4	Neurotrophin 4. (210 aa)
	Magi2	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2. (848 aa)
	Rapgef1	Rap guanine nucleotide exchange factor 1 isoform X1. (1198 aa)
	Ntrk1	Tyrosine-protein kinase receptor. (799 aa)
	Rap1a	Ras-related protein Rap-1A. (178 aa)
	Kidins220	Kinase D-interacting substrate of 220 kDa isoform X1. (1782 aa)
	Ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (261 aa)
	Sort1	Sortilin. (861 aa)
	Nkpd1	NTPase KAP family P-loop domain-containing protein 1. (603 aa)
	LOC106001914	Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
	Coro1a	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	Rapgef2	Rap guanine nucleotide exchange factor 2. (1398 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kidins220	Magi2	ENSDORP00000013942	ENSDORP00000003076	Kinase D-interacting substrate of 220 kDa isoform X1.	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2.	0.906
Kidins220	Ntrk1	ENSDORP00000013942	ENSDORP00000004769	Kinase D-interacting substrate of 220 kDa isoform X1.	Tyrosine-protein kinase receptor.	0.933
Kidins220	Rap1a	ENSDORP00000013942	ENSDORP00000010956	Kinase D-interacting substrate of 220 kDa isoform X1.	Ras-related protein Rap-1A.	0.614
LOC106001914	Ntrk1	ENSDORP00000019587	ENSDORP00000004769	Neurotrophin-4; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.959
Magi2	Kidins220	ENSDORP00000003076	ENSDORP00000013942	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2.	Kinase D-interacting substrate of 220 kDa isoform X1.	0.906
Magi2	Nkpd1	ENSDORP00000003076	ENSDORP00000019079	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2.	NTPase KAP family P-loop domain-containing protein 1.	0.842
Magi2	Rapgef2	ENSDORP00000003076	ENSDORP00000024152	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2.	Rap guanine nucleotide exchange factor 2.	0.934
Nkpd1	Magi2	ENSDORP00000019079	ENSDORP00000003076	NTPase KAP family P-loop domain-containing protein 1.	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2.	0.842
Nkpd1	Ntrk1	ENSDORP00000019079	ENSDORP00000004769	NTPase KAP family P-loop domain-containing protein 1.	Tyrosine-protein kinase receptor.	0.710
Nkpd1	Rap1a	ENSDORP00000019079	ENSDORP00000010956	NTPase KAP family P-loop domain-containing protein 1.	Ras-related protein Rap-1A.	0.610
Ntf3	Ntrk1	ENSDORP00000016129	ENSDORP00000004769	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.978
Ntf3	Rapgef1	ENSDORP00000016129	ENSDORP00000003349	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Rap guanine nucleotide exchange factor 1 isoform X1.	0.505
Ntf3	Sort1	ENSDORP00000016129	ENSDORP00000017860	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	Sortilin.	0.789
Ntf4	Ntrk1	ENSDORP00000021755	ENSDORP00000004769	Neurotrophin 4.	Tyrosine-protein kinase receptor.	0.959
Ntrk1	Kidins220	ENSDORP00000004769	ENSDORP00000013942	Tyrosine-protein kinase receptor.	Kinase D-interacting substrate of 220 kDa isoform X1.	0.933
Ntrk1	LOC106001914	ENSDORP00000004769	ENSDORP00000019587	Tyrosine-protein kinase receptor.	Neurotrophin-4; Belongs to the NGF-beta family.	0.959
Ntrk1	Nkpd1	ENSDORP00000004769	ENSDORP00000019079	Tyrosine-protein kinase receptor.	NTPase KAP family P-loop domain-containing protein 1.	0.710
Ntrk1	Ntf3	ENSDORP00000004769	ENSDORP00000016129	Tyrosine-protein kinase receptor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.978
Ntrk1	Ntf4	ENSDORP00000004769	ENSDORP00000021755	Tyrosine-protein kinase receptor.	Neurotrophin 4.	0.959
Ntrk1	Rap1a	ENSDORP00000004769	ENSDORP00000010956	Tyrosine-protein kinase receptor.	Ras-related protein Rap-1A.	0.568