(91 nodes) Ribosomal large subunit biogenesis network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ddx18	RNA helicase. (628 aa)
	ENSDORP00000022369	annotation not available (102 aa)
	ENSDORP00000022850	annotation not available (157 aa)
	Mrto4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
	Rpf2	Ribosome production factor 2 homolog. (171 aa)
	LOC105997478	60S ribosomal protein L35a pseudogene. (110 aa)
	Bop1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (734 aa)
	Nol9	Polynucleotide 5'-hydroxyl-kinase NOL9. (713 aa)
	Brix1	Ribosome biogenesis protein BRX1 homolog. (353 aa)
	Nop16	Nucleolar protein 16 isoform X1. (182 aa)
	LOC105996833	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
	Ebna1bp2	Probable rRNA-processing protein EBP2. (198 aa)
	Urb1	Nucleolar pre-ribosomal-associated protein 1. (2265 aa)
	Rpl7a	60S ribosomal protein L7a. (266 aa)
	Gtf3a	Transcription factor IIIA. (353 aa)
	Rpl6	60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. (290 aa)
	Rpl5	60S ribosomal protein L5. (302 aa)
	Mdn1	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5541 aa)
	Heatr3	HEAT repeat-containing protein 3. (663 aa)
	Rpl10	60S ribosomal protein L10 isoform X1. (214 aa)
	Ftsj3	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (832 aa)
	Rrp15	RRP15-like protein. (273 aa)
	Znhit2	Zinc finger HIT domain-containing protein 2. (386 aa)
	Traf7	E3 ubiquitin-protein ligase TRAF7 isoform X3. (670 aa)
	Rpl35a	60S ribosomal protein L35a. (110 aa)
	Fastkd2	FAST kinase domain-containing protein 2. (692 aa)
	Gtpbp4	Nucleolar GTP-binding protein 1. (542 aa)
	Eif6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	Rpl24	60S ribosomal protein L24. (157 aa)
	Ppan	Suppressor of SWI4 1 homolog. (344 aa)
	Pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (601 aa)
	ENSDORP00000015376	annotation not available (289 aa)
	Rpl10l	60S ribosomal protein L10-like isoform X1. (214 aa)
	Mrpl1	39S ribosomal protein L1, mitochondrial isoform X1. (337 aa)
	Mak16	Protein MAK16 homolog; Belongs to the MAK16 family. (298 aa)
	Wdr12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (401 aa)
	Pak1ip1	P21-activated protein kinase-interacting protein 1. (245 aa)
	Nvl	Nuclear valosin-containing protein-like isoform X1. (836 aa)
	Malsu1	Mitochondrial assembly of ribosomal large subunit protein 1. (232 aa)
	Noc2l	Nucleolar complex protein 2 homolog isoform X2. (718 aa)
	Rsl1d1	Ribosomal L1 domain-containing protein 1. (400 aa)
	Nsa2	Ribosome biogenesis protein NSA2 homolog. (254 aa)
	Nle1	Notchless protein homolog 1. (488 aa)
	ENSDORP00000000639	annotation not available (126 aa)
	Rpf1	Ribosome production factor 1. (350 aa)
	Spata5	Spermatogenesis-associated protein 5. (796 aa)
	LTO1	Oral cancer-overexpressed protein 1. (153 aa)
	Rpl11	60S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
	Rpl7l1	60S ribosomal protein L7-like 1. (246 aa)
	Rpl35	60S ribosomal protein L35. (123 aa)
	LOC105998480	60S ribosomal protein L7a pseudogene. (228 aa)
	Mrm2	rRNA methyltransferase 2, mitochondrial isoform X2. (238 aa)
	Rpl26	60S ribosomal protein L26. (145 aa)
	ENSDORP00000022305	annotation not available (242 aa)
	Las1l	Ribosomal biogenesis protein LAS1L isoform X3. (786 aa)
	Rpl23a	60S ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family. (156 aa)
	Ddx28	Probable ATP-dependent RNA helicase DDX28. (540 aa)
	Znhit3	Zinc finger HIT domain-containing protein 3. (152 aa)
	ENSDORP00000025391	annotation not available (110 aa)
	ENSDORP00000025912	annotation not available (138 aa)
	ENSDORP00000026490	annotation not available (137 aa)
	ENSDORP00000027268	annotation not available (264 aa)
	ENSDORP00000027414	annotation not available (133 aa)
	Nip7	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
	LOC105984408	60S ribosomal protein L10-like. (213 aa)
	Surf6	Surfeit locus protein 6. (347 aa)
	Mrpl20	39S ribosomal protein L20, mitochondrial. (83 aa)
	ENSDORP00000016618	annotation not available (126 aa)
	ENSDORP00000016922	annotation not available (98 aa)
	ENSDORP00000016996	annotation not available (186 aa)
	Dhx30	Putative ATP-dependent RNA helicase DHX30 isoform X2. (1221 aa)
	Rsl24d1	Probable ribosome biogenesis protein RLP24. (153 aa)
	Znhit6	Box C/D snoRNA protein 1. (451 aa)
	Snu13	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
	ENSDORP00000018851	annotation not available (139 aa)
	ENSDORP00000019328	annotation not available (132 aa)
	Znf622	Zinc finger protein 622. (476 aa)
	LOC105985345	60S ribosomal protein L7 pseudogene. (238 aa)
	ENSDORP00000019793	annotation not available (91 aa)
	Rpl10a	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family. (217 aa)
	ENSDORP00000020215	annotation not available (110 aa)
	Wdr74	WD repeat-containing protein 74. (341 aa)
	Rplp0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
	LOC105982000	60S acidic ribosomal protein P0 pseudogene. (300 aa)
	Rpl7	60S ribosomal protein L7. (207 aa)
	ENSDORP00000021010	annotation not available (177 aa)
	Rrs1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (264 aa)
	Sdad1	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (688 aa)
	ENSDORP00000021912	annotation not available (60 aa)
	Npm1	Nucleophosmin. (273 aa)
	ENSDORP00000022299	annotation not available (209 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bop1	Brix1	ENSDORP00000024112	ENSDORP00000008806	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis protein BRX1 homolog.	0.998
Bop1	Ddx18	ENSDORP00000024112	ENSDORP00000010659	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	RNA helicase.	0.999
Bop1	Ddx28	ENSDORP00000024112	ENSDORP00000025211	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Probable ATP-dependent RNA helicase DDX28.	0.948
Bop1	ENSDORP00000000639	ENSDORP00000024112	ENSDORP00000000639	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.832
Bop1	ENSDORP00000015376	ENSDORP00000024112	ENSDORP00000015376	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.813
Bop1	ENSDORP00000016618	ENSDORP00000024112	ENSDORP00000016618	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.874
Bop1	ENSDORP00000016922	ENSDORP00000024112	ENSDORP00000016922	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.842
Bop1	ENSDORP00000016996	ENSDORP00000024112	ENSDORP00000016996	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.967
Bop1	ENSDORP00000018851	ENSDORP00000024112	ENSDORP00000018851	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.874
Bop1	ENSDORP00000019328	ENSDORP00000024112	ENSDORP00000019328	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.775
Bop1	ENSDORP00000019793	ENSDORP00000024112	ENSDORP00000019793	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.836
Bop1	ENSDORP00000020215	ENSDORP00000024112	ENSDORP00000020215	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.836
Bop1	ENSDORP00000021010	ENSDORP00000024112	ENSDORP00000021010	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.967
Bop1	ENSDORP00000021912	ENSDORP00000024112	ENSDORP00000021912	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.836
Bop1	ENSDORP00000022299	ENSDORP00000024112	ENSDORP00000022299	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.543
Bop1	ENSDORP00000022305	ENSDORP00000024112	ENSDORP00000022305	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.964
Bop1	ENSDORP00000022369	ENSDORP00000024112	ENSDORP00000022369	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.842
Bop1	ENSDORP00000022850	ENSDORP00000024112	ENSDORP00000022850	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.874
Bop1	ENSDORP00000025391	ENSDORP00000024112	ENSDORP00000025391	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.836
Bop1	ENSDORP00000025912	ENSDORP00000024112	ENSDORP00000025912	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	annotation not available	0.945