43 items (Dipodomys ordii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSDORP00000017549	annotation not available (195 aa)
	ENSDORP00000016493	annotation not available (144 aa)
	ENSDORP00000015336	annotation not available (189 aa)
	Efcab7	EF-hand calcium-binding domain-containing protein 7. (628 aa)
	Zc3h12a	Ribonuclease ZC3H12A. (592 aa)
	Uaca	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1377 aa)
	Hdac3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (432 aa)
	Chp2	Calcineurin B homologous protein 2. (196 aa)
	Bag3	BAG family molecular chaperone regulator 3 isoform X2. (578 aa)
	Hsp90ab1	Heat shock protein HSP 90-beta. (723 aa)
	Ipo5	Importin-5. (1083 aa)
	Tardbp	TAR DNA-binding protein 43 isoform X1. (414 aa)
	Dmap1	DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
	Ptpn5	Tyrosine-protein phosphatase non-receptor type 5 isoform X1. (369 aa)
	Hsp90aa1	Heat shock protein HSP 90-alpha. (733 aa)
	Rbm22	pre-mRNA-splicing factor RBM22. (358 aa)
	Smo	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	Ect2	Protein ECT2. (901 aa)
	Tpr	Nucleoprotein TPR isoform X1. (556 aa)
	Mast3	Microtubule associated serine/threonine kinase 3. (71 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Mavs	Mitochondrial antiviral-signaling protein. (476 aa)
	Tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
	Cdh1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Gli3	Transcriptional activator GLI3. (1508 aa)
	ENSDORP00000025871	annotation not available (284 aa)
	Gper1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	Ubr5	E3 ubiquitin-protein ligase UBR5. (2795 aa)
	Prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
	Mapk14	Mitogen-activated protein kinase. (360 aa)
	Tek	Angiopoietin-1 receptor isoform X1. (1125 aa)
	Zpr1	Zinc finger protein ZPR1 isoform X1. (459 aa)
	Prkd1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (847 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (79 aa)
	Jak2	Tyrosine-protein kinase. (1037 aa)
	Hcls1	Hematopoietic lineage cell-specific protein isoform X1. (477 aa)
	Prkcd	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	Trim28	Transcription intermediary factor 1-beta. (834 aa)
	LOC105996339	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	Jup	Junction plakoglobin isoform X1. (745 aa)
	Flna	filamin-A isoform X1. (2647 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bag3	Hsp90aa1	ENSDORP00000010832	ENSDORP00000005210	BAG family molecular chaperone regulator 3 isoform X2.	Heat shock protein HSP 90-alpha.	0.560
Bag3	Hsp90ab1	ENSDORP00000010832	ENSDORP00000010323	BAG family molecular chaperone regulator 3 isoform X2.	Heat shock protein HSP 90-beta.	0.706
Bag3	Jak2	ENSDORP00000010832	ENSDORP00000019264	BAG family molecular chaperone regulator 3 isoform X2.	Tyrosine-protein kinase.	0.554
Bag3	Mast3	ENSDORP00000010832	ENSDORP00000003965	BAG family molecular chaperone regulator 3 isoform X2.	Microtubule associated serine/threonine kinase 3.	0.505
Bag3	Pik3r1	ENSDORP00000010832	ENSDORP00000020150	BAG family molecular chaperone regulator 3 isoform X2.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.505
Brca1	ENSDORP00000015336	ENSDORP00000019851	ENSDORP00000015336	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	annotation not available	0.770
Brca1	ENSDORP00000025871	ENSDORP00000019851	ENSDORP00000025871	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	annotation not available	0.444
Brca1	Flna	ENSDORP00000019851	ENSDORP00000017294	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	filamin-A isoform X1.	0.621
Brca1	Hdac3	ENSDORP00000019851	ENSDORP00000011840	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.444
Brca1	LOC105996339	ENSDORP00000019851	ENSDORP00000018263	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.770
Brca1	Pik3r1	ENSDORP00000019851	ENSDORP00000020150	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.446
Brca1	Uaca	ENSDORP00000019851	ENSDORP00000011906	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Uveal autoantigen with coiled-coil domains and ankyrin repeats.	0.480
Cdh1	Ect2	ENSDORP00000001936	ENSDORP00000004583	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Protein ECT2.	0.422
Cdh1	Hcls1	ENSDORP00000001936	ENSDORP00000018881	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Hematopoietic lineage cell-specific protein isoform X1.	0.435
Cdh1	Jup	ENSDORP00000001936	ENSDORP00000017676	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Junction plakoglobin isoform X1.	0.994
Cdh1	Mapk14	ENSDORP00000001936	ENSDORP00000024477	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Mitogen-activated protein kinase.	0.432
Cdh1	Psen1	ENSDORP00000001936	ENSDORP00000001667	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.888
Cdh1	Tgfb1	ENSDORP00000001936	ENSDORP00000003371	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.449
Chp2	Efcab7	ENSDORP00000011615	ENSDORP00000012909	Calcineurin B homologous protein 2.	EF-hand calcium-binding domain-containing protein 7.	0.401
ENSDORP00000015336	Brca1	ENSDORP00000015336	ENSDORP00000019851	annotation not available	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.770