25 items (Dipodomys ordii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Isl1	Insulin gene enhancer protein ISL-1 isoform X1. (349 aa)
	Sp1	Transcription factor Sp1. (786 aa)
	Ikzf4	Zinc finger protein Eos. (620 aa)
	Kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (755 aa)
	Bhlhe40	Class E basic helix-loop-helix protein 40. (412 aa)
	Ncapg2	Condensin-2 complex subunit G2 isoform X1. (1122 aa)
	Lmo2	Rhombotin-2. (153 aa)
	Runx2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (570 aa)
	Id3	DNA-binding protein inhibitor ID-3. (119 aa)
	Sirt1	NAD-dependent protein deacetylase sirtuin-1. (646 aa)
	Usf1	Upstream stimulatory factor 1 isoform X1. (310 aa)
	Crebbp	CREB-binding protein. (2432 aa)
	Smad3	Mothers against decapentaplegic homolog. (425 aa)
	Myod1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (325 aa)
	Fhl2	Four and a half LIM domains protein 2. (279 aa)
	Usf2	Upstream stimulatory factor 2. (326 aa)
	Tcf12	Transcription factor 12 isoform X1. (703 aa)
	Tcf21	Transcription factor 21 isoform X1. (179 aa)
	Tcf15	Transcription factor 15. (209 aa)
	Klf5	Krueppel-like factor 5. (400 aa)
	Tcf4	Transcription factor 4 isoform X1. (671 aa)
	Figla	Factor in the germline alpha. (184 aa)
	Psmd9	26S proteasome non-ATPase regulatory subunit 9. (213 aa)
	Foxh1	Forkhead box protein H1. (368 aa)
	Hand1	Heart- and neural crest derivatives-expressed protein 1. (214 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Crebbp	Foxh1	ENSDORP00000022325	ENSDORP00000013656	CREB-binding protein.	Forkhead box protein H1.	0.663
Crebbp	Ikzf4	ENSDORP00000022325	ENSDORP00000019416	CREB-binding protein.	Zinc finger protein Eos.	0.508
Crebbp	Kdm1a	ENSDORP00000022325	ENSDORP00000019719	CREB-binding protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.707
Crebbp	Klf5	ENSDORP00000022325	ENSDORP00000027943	CREB-binding protein.	Krueppel-like factor 5.	0.723
Crebbp	Myod1	ENSDORP00000022325	ENSDORP00000023729	CREB-binding protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.806
Crebbp	Runx2	ENSDORP00000022325	ENSDORP00000007166	CREB-binding protein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.793
Crebbp	Sirt1	ENSDORP00000022325	ENSDORP00000020318	CREB-binding protein.	NAD-dependent protein deacetylase sirtuin-1.	0.824
Crebbp	Smad3	ENSDORP00000022325	ENSDORP00000023202	CREB-binding protein.	Mothers against decapentaplegic homolog.	0.956
Crebbp	Sp1	ENSDORP00000022325	ENSDORP00000015987	CREB-binding protein.	Transcription factor Sp1.	0.979
Crebbp	Tcf12	ENSDORP00000022325	ENSDORP00000025143	CREB-binding protein.	Transcription factor 12 isoform X1.	0.861
Crebbp	Tcf4	ENSDORP00000022325	ENSDORP00000011941	CREB-binding protein.	Transcription factor 4 isoform X1.	0.861
Crebbp	Usf1	ENSDORP00000022325	ENSDORP00000022271	CREB-binding protein.	Upstream stimulatory factor 1 isoform X1.	0.773
Crebbp	Usf2	ENSDORP00000022325	ENSDORP00000023792	CREB-binding protein.	Upstream stimulatory factor 2.	0.693
Fhl2	Smad3	ENSDORP00000005089	ENSDORP00000023202	Four and a half LIM domains protein 2.	Mothers against decapentaplegic homolog.	0.419
Figla	Isl1	ENSDORP00000000335	ENSDORP00000015659	Factor in the germline alpha.	Insulin gene enhancer protein ISL-1 isoform X1.	0.452
Figla	Lmo2	ENSDORP00000000335	ENSDORP00000009778	Factor in the germline alpha.	Rhombotin-2.	0.452
Figla	Runx2	ENSDORP00000000335	ENSDORP00000007166	Factor in the germline alpha.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.506
Figla	Tcf12	ENSDORP00000000335	ENSDORP00000025143	Factor in the germline alpha.	Transcription factor 12 isoform X1.	0.736
Figla	Tcf4	ENSDORP00000000335	ENSDORP00000011941	Factor in the germline alpha.	Transcription factor 4 isoform X1.	0.736
Foxh1	Crebbp	ENSDORP00000013656	ENSDORP00000022325	Forkhead box protein H1.	CREB-binding protein.	0.663