12 items (Dipodomys ordii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pik3cb	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
	Insrr	Tyrosine-protein kinase receptor. (1300 aa)
	Ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
	Grb2	Growth factor receptor-bound protein 2. (217 aa)
	Wdr6	WD repeat-containing protein 6. (1015 aa)
	Insr	Tyrosine-protein kinase receptor. (1183 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	Pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	Jak2	Tyrosine-protein kinase. (1037 aa)
	Prkcd	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	Dcaf8	DDB1- and CUL4-associated factor 8. (600 aa)
	Igf1r	Tyrosine-protein kinase receptor. (923 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Grb2	Igf1r	ENSDORP00000027785	ENSDORP00000004240	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.932
Grb2	Insr	ENSDORP00000027785	ENSDORP00000024273	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.878
Grb2	Insrr	ENSDORP00000027785	ENSDORP00000007207	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase receptor.	0.916
Grb2	Jak2	ENSDORP00000027785	ENSDORP00000019264	Growth factor receptor-bound protein 2.	Tyrosine-protein kinase.	0.913
Grb2	Pik3ca	ENSDORP00000027785	ENSDORP00000008976	Growth factor receptor-bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.865
Grb2	Pik3cb	ENSDORP00000027785	ENSDORP00000005935	Growth factor receptor-bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.755
Grb2	Pik3r1	ENSDORP00000027785	ENSDORP00000020150	Growth factor receptor-bound protein 2.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.985
Grb2	Ptpn11	ENSDORP00000027785	ENSDORP00000007760	Growth factor receptor-bound protein 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.997
Grb2	Wdr6	ENSDORP00000027785	ENSDORP00000025329	Growth factor receptor-bound protein 2.	WD repeat-containing protein 6.	0.605
Igf1r	Grb2	ENSDORP00000004240	ENSDORP00000027785	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 2.	0.932
Igf1r	Insrr	ENSDORP00000004240	ENSDORP00000007207	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.889
Igf1r	Jak2	ENSDORP00000004240	ENSDORP00000019264	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.915
Igf1r	Pik3ca	ENSDORP00000004240	ENSDORP00000008976	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.920
Igf1r	Pik3cb	ENSDORP00000004240	ENSDORP00000005935	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.898
Igf1r	Pik3r1	ENSDORP00000004240	ENSDORP00000020150	Tyrosine-protein kinase receptor.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.957
Igf1r	Prkcd	ENSDORP00000004240	ENSDORP00000018767	Tyrosine-protein kinase receptor.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.598
Igf1r	Ptpn11	ENSDORP00000004240	ENSDORP00000007760	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.889
Insr	Grb2	ENSDORP00000024273	ENSDORP00000027785	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 2.	0.878
Insr	Insrr	ENSDORP00000024273	ENSDORP00000007207	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.885
Insr	Jak2	ENSDORP00000024273	ENSDORP00000019264	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.859