STRINGSTRING
Abat Abat Abcg1 Abcg1 Snx4 Snx4 Sirt1 Sirt1 Galr1 Galr1 Mpc2 Mpc2 Pax6 Pax6 ENSDORP00000021076 ENSDORP00000021076 Nnat Nnat Baiap3 Baiap3 Atg7 Atg7 Fgfr1 Fgfr1 Lrp1 Lrp1 Trpm4 Trpm4 C1qtnf6 C1qtnf6 Edn1 Edn1 Gpr68 Gpr68 Gper1 Gper1 Arhgef7 Arhgef7 Ppp3cb Ppp3cb Gck Gck Lif Lif Vsnl1 Vsnl1 ENSDORP00000026799 ENSDORP00000026799 Cntf Cntf Tnfsf11 Tnfsf11 Cftr Cftr LOC106002396 LOC106002396 Doc2b Doc2b Lep Lep Hif1a Hif1a Aacs Aacs Bmp6 Bmp6 Kiss1r Kiss1r Aimp1 Aimp1 Phpt1 Phpt1 Ptger4 Ptger4 Inhbb Inhbb Pfkm Pfkm Pfkfb2 Pfkfb2 Osbp Osbp Tmf1 Tmf1 Gpr39 Gpr39 Pck2 Pck2 Bad Bad Gcg Gcg C2cd2l C2cd2l Mcu Mcu Tfr2 Tfr2 Glrx Glrx Pla2g6 Pla2g6 Rph3al Rph3al Stx4 Stx4 Glp1r Glp1r Sirt6 Sirt6 Kiss1 Kiss1 Pparg Pparg Oga Oga Rasl10b Rasl10b Ffar4 Ffar4 Rbp4 Rbp4 Edn2 Edn2 Ghrhr Ghrhr Adcy8 Adcy8 Blk Blk Glul Glul Capn10 Capn10 Apln Apln Tardbp Tardbp Hnf1a Hnf1a Ptpn11 Ptpn11 Pdx1 Pdx1 Nlgn2 Nlgn2 Lrrc8a Lrrc8a Smad4 Smad4 Ppard Ppard Cyp19a1 Cyp19a1 Nucb2 Nucb2 LOC105998757 LOC105998757 LOC106001615 LOC106001615 Kif5b Kif5b Fga Fga Fgg Fgg Ucn Ucn Prkce Prkce Vamp8 Vamp8 Nadk Nadk Tcf7l2 Tcf7l2 Irs1 Irs1 Creb1 Creb1 Egfr Egfr Hcar2 Hcar2 Cask Cask Psmd9 Psmd9 Drd2 Drd2 Rfx6 Rfx6 Crh Crh Cckbr Cckbr Rac1 Rac1 Acvr2a Acvr2a Acsl4 Acsl4 Ncoa6 Ncoa6 C1qtnf12 C1qtnf12 Sybu Sybu C1qtnf3 C1qtnf3 C1qtnf1 C1qtnf1 Fgb Fgb Ghrl Ghrl Sri Sri Trpa1 Trpa1 Cd38 Cd38 Itsn1 Itsn1 Selenot Selenot Vdr Vdr Adcyap1 Adcyap1 Pex5l Pex5l Edn3 Edn3 Dab2 Dab2 Nr0b2 Nr0b2 Nr1h4 Nr1h4 Ffar1 Ffar1 Rab8b Rab8b Gpld1 Gpld1 Vamp7 Vamp7 Ildr1 Ildr1 Nkx3-1 Nkx3-1 Trpm2 Trpm2 Jak2 Jak2 Gabbr1 Gabbr1 Ano1 Ano1 Arrb1 Arrb1 Cyp27b1 Cyp27b1 Sox4 Sox4 Fgfr4 Fgfr4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Abat4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
Abcg1ATP-binding cassette sub-family G member 1. (672 aa)
Snx4Sorting nexin 4. (392 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (646 aa)
Galr1Galanin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (326 aa)
Mpc2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
Pax6Paired box protein Pax-6 isoform X2. (561 aa)
ENSDORP00000021076annotation not available (173 aa)
NnatNeuronatin isoform X2. (81 aa)
Baiap3BAI1-associated protein 3. (1028 aa)
Atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Lrp1Prolow-density lipoprotein receptor-related protein 1. (4543 aa)
Trpm4Transient receptor potential cation channel subfamily M member 4. (1206 aa)
C1qtnf6Complement C1q tumor necrosis factor-related protein 6. (103 aa)
Edn1Endothelin-1-like isoform X1. (202 aa)
Gpr68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
Arhgef7Rho guanine nucleotide exchange factor 7. (820 aa)
Ppp3cbSerine/threonine-protein phosphatase. (492 aa)
GckPhosphotransferase. (466 aa)
LifLeukemia inhibitory factor. (202 aa)
Vsnl1Visinin-like protein 1 isoform X1. (191 aa)
ENSDORP00000026799annotation not available (256 aa)
CntfCiliary neurotrophic factor. (197 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
CftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1417 aa)
LOC106002396Transcription factor 7-like 2. (125 aa)
Doc2bDouble C2-like domain-containing protein beta. (287 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Hif1aHypoxia-inducible factor 1-alpha. (246 aa)
Aacsacetoacetyl-CoA synthetase. (574 aa)
Bmp6Bone morphogenetic protein 6. (504 aa)
Kiss1rkiSS-1 receptor. (391 aa)
Aimp1Aminoacyl tRNA synthase complex-interacting multifunctional protein 1. (346 aa)
Phpt114 kDa phosphohistidine phosphatase. (122 aa)
Ptger4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (514 aa)
InhbbInhibin beta B chain. (659 aa)
PfkmATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
Pfkfb26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1. (483 aa)
OsbpOxysterol-binding protein; Belongs to the OSBP family. (682 aa)
Tmf1TATA element modulatory factor. (1011 aa)
Gpr39G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (447 aa)
Pck2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (643 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
GcgGlucagon isoform X1. (180 aa)
C2cd2lC2 domain-containing protein 2-like. (266 aa)
McuCalcium uniporter protein, mitochondrial. (283 aa)
Tfr2Transferrin receptor protein 2. (805 aa)
GlrxGlutaredoxin-1. (106 aa)
Pla2g685/88 kDa calcium-independent phospholipase A2. (802 aa)
Rph3alRab effector Noc2. (302 aa)
Stx4Syntaxin-4; Belongs to the syntaxin family. (297 aa)
Glp1rGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (331 aa)
Sirt6NAD-dependent protein deacetylase sirtuin-6. (328 aa)
Kiss1Metastasis-suppressor KiSS-1. (128 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
OgaProtein O-GlcNAcase. (916 aa)
Rasl10bRas-like protein family member 10B. (293 aa)
Ffar4Free fatty acid receptor 4. (383 aa)
Rbp4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (239 aa)
Edn2Endothelin-2 isoform X1. (178 aa)
GhrhrGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (392 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
BlkTyrosine-protein kinase. (497 aa)
GlulGlutamine synthetase. (373 aa)
Capn10Calpain-10; Belongs to the peptidase C2 family. (501 aa)
AplnApelin. (77 aa)
TardbpTAR DNA-binding protein 43 isoform X1. (414 aa)
Hnf1aHepatocyte nuclear factor 1-alpha. (631 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Pdx1Pancreas/duodenum homeobox protein 1. (283 aa)
Nlgn2Neuroligin-2 isoform X1. (835 aa)
Lrrc8aVolume-regulated anion channel subunit LRRC8A. (810 aa)
Smad4Mothers against decapentaplegic homolog. (528 aa)
PpardPeroxisome proliferator-activated receptor delta isoform X1. (433 aa)
Cyp19a1Aromatase; Belongs to the cytochrome P450 family. (503 aa)
Nucb2Nucleobindin-2. (433 aa)
LOC105998757Resistin-like. (112 aa)
LOC106001615Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (264 aa)
Kif5bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
FgaFibrinogen alpha chain. (771 aa)
FggFibrinogen gamma chain. (437 aa)
UcnUrocortin. (130 aa)
PrkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (548 aa)
Vamp8Vesicle-associated membrane protein 8. (103 aa)
NadkNAD kinase. (448 aa)
Tcf7l2Transcription factor 7-like 2. (299 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Hcar2Hydroxycarboxylic acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (357 aa)
CaskPeripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family. (927 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (213 aa)
Drd2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (443 aa)
Rfx6DNA-binding protein RFX6. (923 aa)
CrhCorticoliberin. (188 aa)
CckbrGastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family. (424 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Acsl4long-chain-fatty-acid--CoA ligase 4 isoform X1. (711 aa)
Ncoa6Nuclear receptor coactivator 6 isoform X1. (503 aa)
C1qtnf12Adipolin. (252 aa)
SybuSyntabulin. (660 aa)
C1qtnf3Complement C1q tumor necrosis factor-related protein 3. (275 aa)
C1qtnf1Complement C1q tumor necrosis factor-related protein 1. (275 aa)
FgbFibrinogen beta chain. (477 aa)
GhrlAppetite-regulating hormone isoform X1. (125 aa)
SriSorcin. (198 aa)
Trpa1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1081 aa)
Cd38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. (308 aa)
Itsn1Intersectin-1. (1221 aa)
SelenotSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
VdrVitamin D3 receptor. (75 aa)
Adcyap1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
Pex5lPEX5-related protein isoform X1. (650 aa)
Edn3Endothelin-3. (206 aa)
Dab2Disabled homolog 2 isoform X4. (235 aa)
Nr0b2Nuclear receptor subfamily 0 group B member 2. (260 aa)
Nr1h4Bile acid receptor isoform X1. (486 aa)
Ffar1Free fatty acid receptor 1. (300 aa)
Rab8bRas-related protein Rab-8B. (207 aa)
Gpld1Phosphatidylinositol-glycan-specific phospholipase D. (830 aa)
Vamp7Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family. (220 aa)
Ildr1Immunoglobulin-like domain-containing receptor 1 isoform X1. (545 aa)
Nkx3-1Homeobox protein Nkx-3.1. (138 aa)
Trpm2LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 2. (1444 aa)
Jak2Tyrosine-protein kinase. (1037 aa)
Gabbr1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (961 aa)
Ano1Anoctamin. (919 aa)
Arrb1Beta-arrestin-1 isoform X1. (411 aa)
Cyp27b125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (508 aa)
Sox4Transcription factor SOX. (249 aa)
Fgfr4Fibroblast growth factor receptor. (766 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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