STRINGSTRING
Klf7 Klf7 Abcc8 Abcc8 Nucb2 Nucb2 Nos1 Nos1 Cry1 Cry1 Ptpn11 Ptpn11 LOC105990733 LOC105990733 Ppp3ca Ppp3ca Eny2 Eny2 Ccn3 Ccn3 Chga Chga Lif Lif Sirt4 Sirt4 Vsnl1 Vsnl1 Crhbp Crhbp Midn Midn Inhbb Inhbb Rab11fip1 Rab11fip1 Npvf Npvf Pde1c Pde1c Srebf1 Srebf1 Madd Madd Jagn1 Jagn1 Fkbp1b Fkbp1b Stxbp5l Stxbp5l Ndufaf2 Ndufaf2 Pfkl Pfkl Anxa5 Anxa5 Edn2 Edn2 Pde8b Pde8b Cartpt Cartpt Mtnr1a Mtnr1a Igfbp3 Igfbp3 Lep Lep Ffar4 Ffar4 Pparg Pparg Inha Inha Pde3b Pde3b ENSDORP00000020542 ENSDORP00000020542 Mtnr1b Mtnr1b Sirt1 Sirt1 Npff Npff Rest Rest Nrg1 Nrg1 Sytl4 Sytl4 Edn3 Edn3 Sfrp1 Sfrp1 LOC105982040 LOC105982040 Crhr2 Crhr2 Kcnb1 Kcnb1 Ghrl Ghrl Ptger3 Ptger3 Hadh Hadh Foxo1 Foxo1 Ptpmt1 Ptpmt1 Cry2 Cry2 Kalrn Kalrn Pim3 Pim3 Crh Crh Drd2 Drd2 Psmd9 Psmd9 Ghsr Ghsr Rptor Rptor Adipoq Adipoq Il11 Il11 Tspo Tspo Oit1 Oit1 Fbn1 Fbn1 Tbc1d1 Tbc1d1 Ucn Ucn Acvr1c Acvr1c Ucp2 Ucp2 ENSDORP00000009467 ENSDORP00000009467 Il1b Il1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Klf7Krueppel-like factor 7 isoform X1. (301 aa)
Abcc8ATP-binding cassette sub-family C member 8 isoform X1. (1582 aa)
Nucb2Nucleobindin-2. (433 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1423 aa)
Cry1Cryptochrome-1. (576 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
LOC105990733Allergen Fel d 4-like; Belongs to the calycin superfamily. Lipocalin family. (177 aa)
Ppp3caSerine/threonine-protein phosphatase. (479 aa)
Eny2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (101 aa)
Ccn3Protein NOV homolog. (357 aa)
Chgachromogranin-A. (367 aa)
LifLeukemia inhibitory factor. (202 aa)
Sirt4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
Vsnl1Visinin-like protein 1 isoform X1. (191 aa)
CrhbpCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
MidnMidnolin. (433 aa)
InhbbInhibin beta B chain. (659 aa)
Rab11fip1Rab11 family-interacting protein 1 isoform X2. (649 aa)
Npvfpro-FMRFamide-related neuropeptide VF. (192 aa)
Pde1cPhosphodiesterase. (633 aa)
Srebf1Sterol regulatory element-binding protein 1 isoform X1. (1126 aa)
MaddMAP kinase-activating death domain protein. (1548 aa)
Jagn1Protein jagunal homolog 1. (153 aa)
Fkbp1bPeptidylprolyl isomerase. (108 aa)
Stxbp5lSyntaxin-binding protein 5-like isoform X1. (1185 aa)
Ndufaf2Mimitin, mitochondrial. (169 aa)
PfklATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (770 aa)
Anxa5Annexin. (321 aa)
Edn2Endothelin-2 isoform X1. (178 aa)
Pde8bPhosphodiesterase. (783 aa)
CartptCocaine- and amphetamine-regulated transcript protein isoform X1. (136 aa)
Mtnr1aMelatonin receptor type 1A; Belongs to the G-protein coupled receptor 1 family. (354 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (172 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Ffar4Free fatty acid receptor 4. (383 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
InhaInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (371 aa)
Pde3bPhosphodiesterase. (1011 aa)
ENSDORP00000020542annotation not available (55 aa)
Mtnr1bMelatonin receptor type 1B; Belongs to the G-protein coupled receptor 1 family. (363 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (646 aa)
Npffpro-FMRFamide-related neuropeptide FF. (109 aa)
RestRE1-silencing transcription factor isoform X2. (329 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
Sytl4Synaptotagmin-like protein 4 isoform X1. (672 aa)
Edn3Endothelin-3. (206 aa)
Sfrp1Secreted frizzled-related protein 1. (314 aa)
LOC105982040Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (97 aa)
Crhr2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (411 aa)
Kcnb1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (850 aa)
GhrlAppetite-regulating hormone isoform X1. (125 aa)
Ptger3Prostaglandin E2 receptor EP3 subtype. (390 aa)
HadhHydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform X1. (314 aa)
Foxo1Forkhead box protein O1. (537 aa)
Ptpmt1Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1. (209 aa)
Cry2Cryptochrome-2. (593 aa)
KalrnKalirin isoform X2. (2981 aa)
Pim3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (309 aa)
CrhCorticoliberin. (188 aa)
Drd2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (443 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (213 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
RptorRegulatory-associated protein of mTOR. (1310 aa)
AdipoqAdiponectin. (251 aa)
Il11Interleukin-11. (197 aa)
TspoTranslocator protein. (168 aa)
Oit1Protein FAM3D isoform X1. (218 aa)
Fbn1Fibrillin-1. (2873 aa)
Tbc1d1TBC1 domain family member 1 isoform X6. (1246 aa)
UcnUrocortin. (130 aa)
Acvr1cReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (363 aa)
Ucp2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ENSDORP00000009467annotation not available (260 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (24%) [HD]