STRINGSTRING
Jak2 Jak2 Tlr4 Tlr4 Ptk2 Ptk2 Pik3r1 Pik3r1 Pde4d Pde4d Aif1 Aif1 ENSDORP00000020585 ENSDORP00000020585 LOC105990162 LOC105990162 Il13 Il13 Cdkn1b Cdkn1b Igf1 Igf1 Sod2 Sod2 Htr1b Htr1b Ern1 Ern1 Map3k5 Map3k5 Itga2 Itga2 LOC105989276 LOC105989276 Ndrg4 Ndrg4 Ogn Ogn Tnfaip3 Tnfaip3 Cnn1 Cnn1 Pparg Pparg Apoe Apoe Shc1 Shc1 Mtor Mtor Comt Comt Hif1a Hif1a Prkdc Prkdc Igfbp3 Igfbp3 Phb Phb Igf1r Igf1r Npr1 Npr1 Ddr2 Ddr2 Ddx39b Ddx39b Myd88 Myd88 Ptgir Ptgir Alox12 Alox12 Akt1 Akt1 Orc1 Orc1 Serpinf2 Serpinf2 Mef2d Mef2d Apln Apln Il12b Il12b Ndrg2 Ndrg2 Nampt Nampt Ereg Ereg Igfbp5 Igfbp5 Prkg1 Prkg1 Pten Pten Ppard Ppard Bmpr2 Bmpr2 Pik3ca Pik3ca Bmpr1a Bmpr1a Ager Ager Efemp2 Efemp2 Bmp4 Bmp4 Bmp2 Bmp2 Hdac4 Hdac4 Ralbp1 Ralbp1 Flt1 Flt1 Pdgfb Pdgfb Ccdc142 Ccdc142 Ldlrap1 Ldlrap1 Camk2d Camk2d S1pr1 S1pr1 Foxj2 Foxj2 Nos3 Nos3 Nox1 Nox1 ENSDORP00000023223 ENSDORP00000023223 Gsk3b Gsk3b Ccn4 Ccn4 Insr Insr Pdgfrb Pdgfrb Mnat1 Mnat1 Edn1 Edn1 Gper1 Gper1 Myc Myc Egr1 Egr1 Cdh13 Cdh13 Thbs1 Thbs1 Nppc Nppc Rgs5 Rgs5 Esr2 Esr2 Zfp143 Zfp143 LOC106002396 LOC106002396 Gna12 Gna12 Cav1 Cav1 Xrcc6 Xrcc6 Myocd Myocd Stat1 Stat1 Nr4a3 Nr4a3 Il10 Il10 Agt Agt Npy5r Npy5r Tcf7l2 Tcf7l2 Xrcc5 Xrcc5 Nf1 Nf1 LOC106001479 LOC106001479 Akr1b1 Akr1b1 Tnf Tnf Hbegf Hbegf Il18 Il18 S1pr2 S1pr2 Adipoq Adipoq Tgfb3 Tgfb3 Egfr Egfr Skp2 Skp2 Mmp2 Mmp2 Sulf1 Sulf1 Npr3 Npr3 Ace2 Ace2 Hmox1 Hmox1 Il6r Il6r Cx3cl1 Cx3cl1 Id2 Id2 Tgfbr2 Tgfbr2 Irak4 Irak4 Calcrl Calcrl Smpd3 Smpd3 Dbh Dbh Vip Vip Ppargc1a Ppargc1a Sf1 Sf1 Itgb3 Itgb3 Gna13 Gna13 Traf6 Traf6 Foxp1 Foxp1 Adamts1 Adamts1 P2ry6 P2ry6 Fgfr2 Fgfr2 Pak1 Pak1 Pdcd4 Pdcd4 Frs2 Frs2 Irak1 Irak1 Mef2c Mef2c Apod Apod Fgf2 Fgf2 Trib1 Trib1 Notch3 Notch3 Cyba Cyba
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Jak2Tyrosine-protein kinase. (1037 aa)
Tlr4Toll-like receptor 4 isoform X2; Belongs to the Toll-like receptor family. (842 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Pde4dPhosphodiesterase. (746 aa)
Aif1Allograft inflammatory factor 1 isoform X1. (147 aa)
ENSDORP00000020585annotation not available (80 aa)
LOC105990162Prohibitin pseudogene. (194 aa)
Il13Interleukin-13 isoform X2. (127 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
Htr1b5-hydroxytryptamine receptor 1B. (394 aa)
Ern1Serine/threonine-protein kinase/endoribonuclease IRE1. (406 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5. (144 aa)
Itga2Integrin alpha-2; Belongs to the integrin alpha chain family. (1167 aa)
LOC105989276Glutathione S-transferase P; Belongs to the GST superfamily. (210 aa)
Ndrg4Protein NDRG4 isoform X1. (404 aa)
OgnMimecan. (266 aa)
Tnfaip3Tumor necrosis factor alpha-induced protein 3. (329 aa)
Cnn1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ApoeApolipoprotein E. (274 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (267 aa)
Hif1aHypoxia-inducible factor 1-alpha. (246 aa)
PrkdcDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (4088 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (172 aa)
PhbProhibitin. (272 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Npr1Guanylate cyclase. (1060 aa)
Ddr2Discoidin domain-containing receptor 2. (855 aa)
Ddx39bSpliceosome RNA helicase DDX39B. (399 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (338 aa)
PtgirProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Alox12Arachidonate 12-lipoxygenase, 12S-type. (664 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (839 aa)
Serpinf2Alpha-2-antiplasmin; Belongs to the serpin family. (411 aa)
Mef2dMyocyte-specific enhancer factor 2D. (513 aa)
AplnApelin. (77 aa)
Il12bInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
Ndrg2Protein NDRG2 isoform X1. (371 aa)
NamptNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
EregProepiregulin. (163 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
Prkg1cGMP-dependent protein kinase. (686 aa)
PtenPhosphatase and tensin homolog. (396 aa)
PpardPeroxisome proliferator-activated receptor delta isoform X1. (433 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (933 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AgerAdvanced glycosylation end product-specific receptor. (233 aa)
Efemp2EGF-containing fibulin-like extracellular matrix protein 2. (443 aa)
Bmp4Bone morphogenetic protein 4. (409 aa)
Bmp2Bone morphogenetic protein 2. (398 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
Ralbp1ralA-binding protein 1. (654 aa)
Flt1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1331 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
Ccdc142Coiled-coil domain-containing protein 142. (722 aa)
Ldlrap1Low density lipoprotein receptor adapter protein 1. (308 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (533 aa)
S1pr1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Foxj2Forkhead box J2. (451 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1201 aa)
Nox1NADPH oxidase 1 isoform X1. (567 aa)
ENSDORP00000023223annotation not available (74 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Ccn4WNT1-inducible-signaling pathway protein 1 isoform X1. (367 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
Mnat1CDK-activating kinase assembly factor MAT1. (281 aa)
Edn1Endothelin-1-like isoform X1. (202 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
Cdh13Cadherin-13. (714 aa)
Thbs1Thrombospondin-1. (1173 aa)
NppcC-type natriuretic peptide. (126 aa)
Rgs5Regulator of G-protein signaling 5. (181 aa)
Esr2Estrogen receptor beta. (550 aa)
Zfp143Zinc finger protein 143 isoform X2. (637 aa)
LOC106002396Transcription factor 7-like 2. (125 aa)
Gna12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
Xrcc6X-ray repair cross-complementing protein 6. (585 aa)
MyocdMyocardin. (923 aa)
Stat1Signal transducer and activator of transcription. (765 aa)
Nr4a3Nuclear receptor subfamily 4 group A member 3. (390 aa)
Il10Interleukin-10. (178 aa)
AgtAngiotensinogen; Belongs to the serpin family. (473 aa)
Npy5rNeuropeptide Y receptor type 5. (446 aa)
Tcf7l2Transcription factor 7-like 2. (299 aa)
Xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (692 aa)
Nf1Neurofibromin isoform X1. (2841 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Akr1b1Aldose reductase. (316 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
HbegfProheparin-binding EGF-like growth factor. (206 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (183 aa)
S1pr2Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
AdipoqAdiponectin. (251 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Skp2S-phase kinase-associated protein 2 isoform X1. (424 aa)
Mmp272 kDa type IV collagenase. (126 aa)
Sulf1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
Npr3Atrial natriuretic peptide receptor 3 isoform X1. (541 aa)
Ace2Angiotensin-converting enzyme. (805 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (285 aa)
Il6rInterleukin-6 receptor subunit alpha. (445 aa)
Cx3cl1Fractalkine. (385 aa)
Id2DNA-binding protein inhibitor ID-2. (116 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Irak4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
CalcrlCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (449 aa)
Smpd3Sphingomyelin phosphodiesterase 3. (653 aa)
DbhDopamine beta-hydroxylase. (620 aa)
VipVIP peptides isoform X1. (170 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (797 aa)
Sf1Splicing factor 1 isoform X4. (642 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (766 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (372 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
Foxp1Forkhead box protein P1 isoform X1. (700 aa)
Adamts1A disintegrin and metalloproteinase with thrombospondin motifs 1. (966 aa)
P2ry6p2Y purinoceptor 6 isoform X3. (327 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Pak1Non-specific serine/threonine protein kinase. (544 aa)
Pdcd4Programmed cell death protein 4 isoform X1. (469 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (714 aa)
Mef2cMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
ApodApolipoprotein D. (189 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Trib1Tribbles homolog 1. (141 aa)
Notch3Neurogenic locus notch homolog protein 3. (2133 aa)
CybaCytochrome b-245 light chain. (176 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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