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Adcy1 Adcy1 Lrrtm1 Lrrtm1 Chrna7 Chrna7 Clstn1 Clstn1 Snap25 Snap25 LOC105994343 LOC105994343 Cacng7 Cacng7 Shank3 Shank3 Baiap3 Baiap3 Oxt Oxt Mme Mme Grin1 Grin1 Clstn3 Clstn3 Rapsn Rapsn Dlg4 Dlg4 Slc8a3 Slc8a3 Arrb2 Arrb2 Grin2d Grin2d Ror2 Ror2 Syt12 Syt12 Slc1a1 Slc1a1 Musk Musk Mpp2 Mpp2 Lrrtm2 Lrrtm2 Iqsec2 Iqsec2 Igsf11 Igsf11 Cacng8 Cacng8 Akap5 Akap5 Lama2 Lama2 Nog Nog Mecp2 Mecp2 Stau1 Stau1 Kmo Kmo Adora1 Adora1 App App Gper1 Gper1 Shisa7 Shisa7 Ccr2 Ccr2 LOC106001939 LOC106001939 Crtc1 Crtc1 Ca2 Ca2 Tshz3 Tshz3 Bcl2l1 Bcl2l1 Dbi Dbi Lgi1 Lgi1 Nfatc4 Nfatc4 Cacna1b Cacna1b LOC106002162 LOC106002162 Cacnb4 Cacnb4 Ptk2 Ptk2 Crhr1 Crhr1 Chrnb2 Chrnb2 Gfap Gfap Sphk1 Sphk1 Nrxn1 Nrxn1 Grik2 Grik2 Pink1 Pink1 Nlgn1 Nlgn1 Clstn2 Clstn2 Unc13a Unc13a Syde1 Syde1 Drd1 Drd1 Adcyap1 Adcyap1 Zdhhc2 Zdhhc2 Dtnbp1 Dtnbp1 Crhr2 Crhr2 Braf Braf Rims1 Rims1 Htr2c Htr2c Reln Reln ENSDORP00000016358 ENSDORP00000016358 Rims2 Rims2 Rgs14 Rgs14 Slc1a3 Slc1a3 Camk2b Camk2b Hnrnpk Hnrnpk Tnr Tnr Slc24a2 Slc24a2 Stx3 Stx3 Sqstm1 Sqstm1 Rims3 Rims3 Cckbr Cckbr S100b S100b Crh Crh Ca7 Ca7 Drd2 Drd2 Zdhhc12 Zdhhc12 Cacng3 Cacng3 Stxbp1 Stxbp1 Nps Nps Egfr Egfr Erbb4 Erbb4 Prrt1 Prrt1 Creb1 Creb1 Fmr1 Fmr1 Tnf Tnf Ephb2 Ephb2 Shank2 Shank2 Grin2a Grin2a Dnm1l Dnm1l Ckap5 Ckap5 Slc4a8 Slc4a8 Cacng4 Cacng4 Cacng2 Cacng2 Stx1b Stx1b Chrd Chrd Prkce Prkce Ptk2b Ptk2b Plk2 Plk2 Grik1 Grik1 Slc8a2 Slc8a2 Ager Ager Kif5b Kif5b LOC105998757 LOC105998757 Snca Snca Nos1 Nos1 Zdhhc3 Zdhhc3 Lgmn Lgmn Pten Pten Enpp1 Enpp1 Nlgn2 Nlgn2 Cnr1 Cnr1 Kctd13 Kctd13 Rab3gap1 Rab3gap1 Oxtr Oxtr Htr6 Htr6 Nr2e1 Nr2e1 Ntrk2 Ntrk2 Nlgn3 Nlgn3 Slc24a1 Slc24a1 Glul Glul Erc1 Erc1 Cdk5 Cdk5 Adcy8 Adcy8 Hap1 Hap1 Ptger4 Ptger4 Ptpn5 Ptpn5 Cpeb3 Cpeb3 Cacng5 Cacng5 Grin2c Grin2c Ntrk1 Ntrk1 Kiss1r Kiss1r Nptn Nptn Ngfr Ngfr Gria2 Gria2 Prkcg Prkcg Vamp2 Vamp2 Syt1 Syt1 Kiss1 Kiss1 Flot1 Flot1 Serpine2 Serpine2 Stx4 Stx4 Nrgn Nrgn Gria1 Gria1 Cacnb2 Cacnb2 Grin2b Grin2b Nalcn Nalcn Itpr3 Itpr3 Eif2ak4 Eif2ak4 Stx1a Stx1a
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (937 aa)
Lrrtm1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
Chrna7Neuronal acetylcholine receptor subunit alpha-7. (568 aa)
Clstn1Calsyntenin-1. (970 aa)
Snap25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
LOC105994343Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (224 aa)
Cacng7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
Shank3SH3 and multiple ankyrin repeat domains protein 3. (1417 aa)
Baiap3BAI1-associated protein 3. (1028 aa)
OxtOxytocin-neurophysin 1; Belongs to the vasopressin/oxytocin family. (125 aa)
MmeNeprilysin. (750 aa)
Grin1LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1. (926 aa)
Clstn3Calsyntenin-3. (948 aa)
Rapsn43 kDa receptor-associated protein of the synapse isoform X1. (412 aa)
Dlg4Disks large homolog 4; Belongs to the MAGUK family. (657 aa)
Slc8a3Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (926 aa)
Arrb2Beta-arrestin-2 isoform X1. (420 aa)
Grin2dGlutamate receptor, ionotropic, NMDA2D (epsilon 4). (1128 aa)
Ror2Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (933 aa)
Syt12Synaptotagmin-12. (421 aa)
Slc1a1Amino acid transporter. (531 aa)
MuskMuscle, skeletal receptor tyrosine-protein kinase isoform X1. (886 aa)
Mpp2MAGUK p55 subfamily member 2; Belongs to the MAGUK family. (569 aa)
Lrrtm2Leucine-rich repeat transmembrane neuronal protein 2 isoform X1. (517 aa)
Iqsec2IQ motif and SEC7 domain-containing protein 2 isoform X1. (1488 aa)
Igsf11Immunoglobulin superfamily member 11. (427 aa)
Cacng8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (415 aa)
Akap5A-kinase anchor protein 5. (438 aa)
Lama2Laminin subunit alpha-2. (3099 aa)
NogNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (233 aa)
Mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
Stau1Double-stranded RNA-binding protein Staufen homolog 1 isoform X2. (495 aa)
KmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (466 aa)
Adora1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (327 aa)
AppAmyloid beta A4 protein isoform X1. (770 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
Shisa7Protein shisa-7. (380 aa)
Ccr2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (367 aa)
LOC106001939Nuclear receptor subfamily 2 group E member 1-like. (90 aa)
Crtc1CREB-regulated transcription coactivator 1. (592 aa)
Ca2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (260 aa)
Tshz3Teashirt homolog 3. (233 aa)
Bcl2l1Bcl-2-like protein 1 isoform X1. (234 aa)
Dbiacyl-CoA-binding protein. (79 aa)
Lgi1Leucine-rich glioma-inactivated protein 1 isoform X1. (557 aa)
Nfatc4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (899 aa)
Cacna1bVoltage-dependent N-type calcium channel subunit alpha-1B. (2037 aa)
LOC106002162Disks large homolog 4-like. (150 aa)
Cacnb4Voltage-dependent L-type calcium channel subunit beta-4. (333 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
Crhr1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (415 aa)
Chrnb2Neuronal acetylcholine receptor subunit beta-2 isoform X1. (504 aa)
GfapGlial fibrillary acidic protein; Belongs to the intermediate filament family. (436 aa)
Sphk1Sphingosine kinase 1. (372 aa)
Nrxn1Neurexin-1-beta isoform X1. (1515 aa)
Grik2Glutamate receptor ionotropic, kainate 2 isoform X1. (908 aa)
Pink1Serine/threonine-protein kinase PINK1, mitochondrial. (577 aa)
Nlgn1Neuroligin-1 isoform X3. (843 aa)
Clstn2Calsyntenin-2. (961 aa)
Unc13aProtein unc-13 homolog A. (1701 aa)
Syde1Rho GTPase-activating protein SYDE1. (384 aa)
Drd1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (447 aa)
Adcyap1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
Zdhhc2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (374 aa)
Dtnbp1Dysbindin. (330 aa)
Crhr2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (411 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Rims1Regulating synaptic membrane exocytosis protein 1 isoform X5. (219 aa)
Htr2c5-hydroxytryptamine receptor 2C. (467 aa)
RelnReelin. (3415 aa)
ENSDORP00000016358annotation not available (337 aa)
Rims2LOW QUALITY PROTEIN: regulating synaptic membrane exocytosis protein 2. (1483 aa)
Rgs14Regulator of G-protein signaling 14. (551 aa)
Slc1a3Amino acid transporter. (542 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta. (644 aa)
HnrnpkHeterogeneous nuclear ribonucleoprotein K isoform X2. (466 aa)
Tnrtenascin-R. (1361 aa)
Slc24a2Sodium/potassium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (665 aa)
Stx3Syntaxin-3; Belongs to the syntaxin family. (286 aa)
Sqstm1Sequestosome-1. (433 aa)
Rims3Regulating synaptic membrane exocytosis protein 3. (308 aa)
CckbrGastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family. (424 aa)
S100bProtein S100; Belongs to the S-100 family. (92 aa)
CrhCorticoliberin. (188 aa)
Ca7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
Drd2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (443 aa)
Zdhhc12Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (275 aa)
Cacng3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
Stxbp1Syntaxin-binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
NpsNeuropeptide S. (89 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Erbb4Receptor protein-tyrosine kinase. (1308 aa)
Prrt1Proline-rich transmembrane protein 1. (306 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Fmr1Fragile X mental retardation protein 1 isoform X1. (616 aa)
TnfTumor necrosis factor isoform X1; Belongs to the tumor necrosis factor family. (220 aa)
Ephb2Ephrin type-B receptor 2 isoform X2. (1018 aa)
Shank2SH3 and multiple ankyrin repeat domains protein 2 isoform X1. (1832 aa)
Grin2aGlutamate receptor ionotropic, NMDA 2A. (1301 aa)
Dnm1lDynamin-1-like protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (727 aa)
Ckap5Cytoskeleton-associated protein 5. (2000 aa)
Slc4a8Anion exchange protein. (1091 aa)
Cacng4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
Cacng2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (295 aa)
Stx1bsyntaxin-1B; Belongs to the syntaxin family. (286 aa)
ChrdChordin isoform X1. (944 aa)
PrkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (548 aa)
Ptk2bProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
Plk2Serine/threonine-protein kinase PLK2. (628 aa)
Grik1Glutamate receptor ionotropic, kainate 1 isoform X1. (926 aa)
Slc8a2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (776 aa)
AgerAdvanced glycosylation end product-specific receptor. (233 aa)
Kif5bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
LOC105998757Resistin-like. (112 aa)
SncaAlpha-synuclein; Belongs to the synuclein family. (140 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1423 aa)
Zdhhc3Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (299 aa)
LgmnLegumain. (436 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (908 aa)
Nlgn2Neuroligin-2 isoform X1. (835 aa)
Cnr1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (471 aa)
Kctd13BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1. (329 aa)
Rab3gap1Rab3 GTPase-activating protein catalytic subunit. (978 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (375 aa)
Htr65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (438 aa)
Nr2e1Nuclear receptor subfamily 2 group E member 1. (173 aa)
Ntrk2Tyrosine-protein kinase receptor. (821 aa)
Nlgn3Neuroligin-3 isoform X1. (848 aa)
Slc24a1Sodium/potassium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1121 aa)
GlulGlutamine synthetase. (373 aa)
Erc1ELKS/Rab6-interacting/CAST family member 1 isoform X2. (1117 aa)
Cdk5Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
Hap1Huntingtin-associated protein 1. (580 aa)
Ptger4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (514 aa)
Ptpn5Tyrosine-protein phosphatase non-receptor type 5 isoform X1. (369 aa)
Cpeb3Cytoplasmic polyadenylation element-binding protein 3. (723 aa)
Cacng5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
Grin2cGlutamate receptor ionotropic, NMDA 2C. (1021 aa)
Ntrk1Tyrosine-protein kinase receptor. (799 aa)
Kiss1rkiSS-1 receptor. (391 aa)
NptnNeuroplastin. (397 aa)
NgfrTumor necrosis factor receptor superfamily member 16. (409 aa)
Gria2Glutamate receptor 2. (842 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
Vamp2Vesicle-associated membrane protein 2 isoform X2. (118 aa)
Syt1Synaptotagmin-1 isoform X1. (422 aa)
Kiss1Metastasis-suppressor KiSS-1. (128 aa)
Flot1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (241 aa)
Serpine2Glia-derived nexin; Belongs to the serpin family. (404 aa)
Stx4Syntaxin-4; Belongs to the syntaxin family. (297 aa)
NrgnNeurogranin. (78 aa)
Gria1Glutamate receptor 1 isoform X2. (906 aa)
Cacnb2Voltage-dependent L-type calcium channel subunit beta-2 isoform X2. (580 aa)
Grin2bGlutamate receptor ionotropic, NMDA 2B. (1103 aa)
NalcnSodium leak channel non-selective protein. (1739 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor type 3 isoform X3. (2668 aa)
Eif2ak4Eukaryotic translation initiation factor 2-alpha kinase 4. (1599 aa)
Stx1asyntaxin-1A; Belongs to the syntaxin family. (288 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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