(61 nodes) Regulation of cytosolic calcium ion concentration network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105988892	cGMP-gated cation channel alpha-1-like. (607 aa)
	Fxyd1	FXYD domain-containing ion transport regulator 1. (79 aa)
	Atp2b1	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1019 aa)
	Tmem178	Transmembrane protein 178A. (163 aa)
	Cacna1a	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (2254 aa)
	Hcrtr2	Orexin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (465 aa)
	Ywhae	14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	Fzd9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
	Cln3	Battenin. (437 aa)
	Tmem64	Transmembrane protein 64. (357 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	Cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	LOC105984099	Short transient receptor potential channel 2; Belongs to the transient receptor (TC 1.A.4) family. (1260 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Fkbp1b	Peptidylprolyl isomerase. (108 aa)
	Chga	chromogranin-A. (367 aa)
	Calb1	Calbindin. (261 aa)
	Gper1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	Itpr1	Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2702 aa)
	Asph	Aspartyl/asparaginyl beta-hydroxylase. (169 aa)
	ENSDORP00000023898	annotation not available (1114 aa)
	Hrc	Sarcoplasmic reticulum histidine-rich calcium-binding protein. (81 aa)
	Ryr1	Ryanodine receptor 1. (4894 aa)
	Slc8a3	Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (926 aa)
	Atp2b2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	Trpc6	Short transient receptor potential channel 6. (513 aa)
	Kcnh1	Potassium voltage-gated channel subfamily H member 1 isoform X1. (990 aa)
	Adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	Grm1	LOW QUALITY PROTEIN: metabotropic glutamate receptor 1. (906 aa)
	Gpr3	G-protein coupled receptor 3; Belongs to the G-protein coupled receptor 1 family. (330 aa)
	LOC105999181	Calcitonin gene-related peptide 2-like. (130 aa)
	Cul5	Cullin-5; Belongs to the cullin family. (751 aa)
	Myh7b	myosin-7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
	Trpc4	Short transient receptor potential channel 4 isoform X2; Belongs to the transient receptor (TC 1.A.4) family. (978 aa)
	Slc8a2	Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (776 aa)
	Trpc7	Short transient receptor potential channel 7 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
	Trpc5	Short transient receptor potential channel 5; Belongs to the transient receptor (TC 1.A.4) family. (966 aa)
	Atp2b3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1085 aa)
	Scgn	Secretagogin. (276 aa)
	Ncs1	Neuronal calcium sensor 1. (168 aa)
	Trpc1	Short transient receptor potential channel 1. (756 aa)
	Ryr2	Ryanodine receptor 2. (4946 aa)
	Cnga1	cGMP-gated cation channel alpha-1. (694 aa)
	Slc35g1	Solute carrier family 35 member G1 isoform X1. (367 aa)
	Tspoap1	Peripheral-type benzodiazepine receptor-associated protein 1. (1836 aa)
	P2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
	Gria1	Glutamate receptor 1 isoform X2. (906 aa)
	Plcd1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1. (482 aa)
	Cacna1e	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2325 aa)
	Grm5	Metabotropic glutamate receptor 5. (1096 aa)
	Hcrtr1	Orexin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (416 aa)
	Cdh23	Cadherin-23 isoform X5. (1363 aa)
	Atp2b4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1230 aa)
	P2ry2	p2Y purinoceptor 2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	Calcb	Calcitonin gene-related peptide 2. (126 aa)
	Trpc3	Short transient receptor potential channel 3 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (836 aa)
	Calb2	Calretinin isoform X1. (271 aa)
	Marcksl1	MARCKS-related protein. (200 aa)
	Bok	Bcl-2-related ovarian killer protein. (138 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (619 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Asph	Fkbp1b	ENSDORP00000024206	ENSDORP00000026622	Aspartyl/asparaginyl beta-hydroxylase.	Peptidylprolyl isomerase.	0.449
Asph	Ryr1	ENSDORP00000024206	ENSDORP00000022536	Aspartyl/asparaginyl beta-hydroxylase.	Ryanodine receptor 1.	0.717
Asph	Ryr2	ENSDORP00000024206	ENSDORP00000004763	Aspartyl/asparaginyl beta-hydroxylase.	Ryanodine receptor 2.	0.717
Atp2b1	Atp2b4	ENSDORP00000019568	ENSDORP00000013751	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.831
Atp2b1	Calb1	ENSDORP00000019568	ENSDORP00000025830	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Calbindin.	0.447
Atp2b1	Calb2	ENSDORP00000019568	ENSDORP00000015093	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Calretinin isoform X1.	0.406
Atp2b1	Fxyd1	ENSDORP00000019568	ENSDORP00000018906	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	FXYD domain-containing ion transport regulator 1.	0.459
Atp2b1	Scgn	ENSDORP00000019568	ENSDORP00000012851	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Secretagogin.	0.400
Atp2b1	Ywhae	ENSDORP00000019568	ENSDORP00000019901	Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	14-3-3 protein epsilon; Belongs to the 14-3-3 family.	0.406
Atp2b2	Atp2b4	ENSDORP00000022311	ENSDORP00000013751	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.799
Atp2b2	Calb1	ENSDORP00000022311	ENSDORP00000025830	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calbindin.	0.426
Atp2b2	Calb2	ENSDORP00000022311	ENSDORP00000015093	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calretinin isoform X1.	0.406
Atp2b2	Fxyd1	ENSDORP00000022311	ENSDORP00000018906	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator 1.	0.459
Atp2b2	Scgn	ENSDORP00000022311	ENSDORP00000012851	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Secretagogin.	0.400
Atp2b2	Ywhae	ENSDORP00000022311	ENSDORP00000019901	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	14-3-3 protein epsilon; Belongs to the 14-3-3 family.	0.406
Atp2b3	Atp2b4	ENSDORP00000012257	ENSDORP00000013751	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.740
Atp2b3	Calb1	ENSDORP00000012257	ENSDORP00000025830	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calbindin.	0.407
Atp2b3	Calb2	ENSDORP00000012257	ENSDORP00000015093	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calretinin isoform X1.	0.406
Atp2b3	Fxyd1	ENSDORP00000012257	ENSDORP00000018906	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	FXYD domain-containing ion transport regulator 1.	0.464
Atp2b3	Scgn	ENSDORP00000012257	ENSDORP00000012851	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Secretagogin.	0.400