(9 nodes) Midbrain dopaminergic neuron differentiation network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	Ryk	Tyrosine-protein kinase RYK isoform X1. (475 aa)
	Lmx1a	LIM homeobox transcription factor 1-alpha. (382 aa)
	Wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	Wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	ENSDORP00000020585	annotation not available (80 aa)
	Wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	Rac1	Ras-related C3 botulinum toxin substrate 1. (187 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSDORP00000020585	Rac1	ENSDORP00000020585	ENSDORP00000013529	annotation not available	Ras-related C3 botulinum toxin substrate 1.	0.748
ENSDORP00000020585	Wnt1	ENSDORP00000020585	ENSDORP00000007249	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.867
ENSDORP00000020585	Wnt2	ENSDORP00000020585	ENSDORP00000015274	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.806
ENSDORP00000020585	Wnt3	ENSDORP00000020585	ENSDORP00000017152	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.774
ENSDORP00000020585	Wnt5a	ENSDORP00000020585	ENSDORP00000022201	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.806
ENSDORP00000020585	Wnt9b	ENSDORP00000020585	ENSDORP00000006055	annotation not available	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.600
Rac1	ENSDORP00000020585	ENSDORP00000013529	ENSDORP00000020585	Ras-related C3 botulinum toxin substrate 1.	annotation not available	0.748
Ryk	Wnt1	ENSDORP00000013230	ENSDORP00000007249	Tyrosine-protein kinase RYK isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.880
Ryk	Wnt2	ENSDORP00000013230	ENSDORP00000015274	Tyrosine-protein kinase RYK isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.846
Ryk	Wnt3	ENSDORP00000013230	ENSDORP00000017152	Tyrosine-protein kinase RYK isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.834
Ryk	Wnt5a	ENSDORP00000013230	ENSDORP00000022201	Tyrosine-protein kinase RYK isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.959
Ryk	Wnt9b	ENSDORP00000013230	ENSDORP00000006055	Tyrosine-protein kinase RYK isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.678
Wnt1	ENSDORP00000020585	ENSDORP00000007249	ENSDORP00000020585	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	annotation not available	0.867
Wnt1	Ryk	ENSDORP00000007249	ENSDORP00000013230	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase RYK isoform X1.	0.880
Wnt1	Wnt2	ENSDORP00000007249	ENSDORP00000015274	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.617
Wnt1	Wnt3	ENSDORP00000007249	ENSDORP00000017152	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.676
Wnt1	Wnt5a	ENSDORP00000007249	ENSDORP00000022201	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.686
Wnt1	Wnt9b	ENSDORP00000007249	ENSDORP00000006055	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.710
Wnt2	ENSDORP00000020585	ENSDORP00000015274	ENSDORP00000020585	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	annotation not available	0.806
Wnt2	Ryk	ENSDORP00000015274	ENSDORP00000013230	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Tyrosine-protein kinase RYK isoform X1.	0.846