(38 nodes) Regulation of T cell migration network (Dipodomys ordii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ccr2	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	Ecm1	Extracellular matrix protein 1 isoform X1. (546 aa)
	Pycard	Apoptosis-associated speck-like protein containing a CARD. (190 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	Crk	Adapter molecule crk. (304 aa)
	Cd200	OX-2 membrane glycoprotein-like isoform X2. (315 aa)
	Coro1a	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	Med23	Mediator of RNA polymerase II transcription subunit 23 isoform X1. (1377 aa)
	Crkl	Crk-like protein. (303 aa)
	Ccl20	C-C motif chemokine. (102 aa)
	Aif1	Allograft inflammatory factor 1 isoform X1. (147 aa)
	Cxcl13	C-X-C motif chemokine 13. (110 aa)
	Cxcl12	Stromal cell-derived factor 1 isoform X2; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	Itga4	Integrin alpha-4; Belongs to the integrin alpha chain family. (1032 aa)
	Apod	Apolipoprotein D. (189 aa)
	Adam8	Disintegrin and metalloproteinase domain-containing protein 8. (778 aa)
	Aire	Autoimmune regulator. (407 aa)
	Itgb3	Integrin beta; Belongs to the integrin beta chain family. (766 aa)
	Adam17	Disintegrin and metalloproteinase domain-containing protein 17. (834 aa)
	Lrch1	Leucine-rich repeat and calponin homology domain-containing protein 1 isoform X1. (715 aa)
	Il27ra	Interleukin-27 receptor subunit alpha isoform X2. (627 aa)
	Ccr6	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	Abl2	Tyrosine-protein kinase. (1132 aa)
	Oxsr1	Serine/threonine-protein kinase OSR1. (496 aa)
	Spn	Leukosialin. (371 aa)
	Cd99l2	CD99 antigen-like protein 2. (221 aa)
	Tmem102	Transmembrane protein 102. (506 aa)
	Selenok	Selenoprotein K. (93 aa)
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (746 aa)
	Dock8	Dedicator of cytokinesis protein 8 isoform X1; Belongs to the DOCK family. (2099 aa)
	Ccl21	C-C motif chemokine 21. (134 aa)
	Wnk1	Serine/threonine-protein kinase WNK1. (2110 aa)
	2610528A11Rik	RIKEN cDNA 2610528A11 gene. (81 aa)
	Spns2	Protein spinster homolog 2. (526 aa)
	ENSDORP00000026600	annotation not available (64 aa)
	Ripor2	Protein FAM65B isoform X2. (1097 aa)
	Ccl27	C-C motif chemokine 27. (118 aa)
	App	Amyloid beta A4 protein isoform X1. (770 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abl2	Crk	ENSDORP00000011753	ENSDORP00000022183	Tyrosine-protein kinase.	Adapter molecule crk.	0.980
Abl2	Crkl	ENSDORP00000011753	ENSDORP00000021103	Tyrosine-protein kinase.	Crk-like protein.	0.949
Abl2	Il27ra	ENSDORP00000011753	ENSDORP00000012471	Tyrosine-protein kinase.	Interleukin-27 receptor subunit alpha isoform X2.	0.413
Adam10	Adam17	ENSDORP00000006997	ENSDORP00000013418	Disintegrin and metalloproteinase domain-containing protein 10.	Disintegrin and metalloproteinase domain-containing protein 17.	0.896
Adam10	App	ENSDORP00000006997	ENSDORP00000025489	Disintegrin and metalloproteinase domain-containing protein 10.	Amyloid beta A4 protein isoform X1.	0.785
Adam17	Adam10	ENSDORP00000013418	ENSDORP00000006997	Disintegrin and metalloproteinase domain-containing protein 17.	Disintegrin and metalloproteinase domain-containing protein 10.	0.896
Adam17	App	ENSDORP00000013418	ENSDORP00000025489	Disintegrin and metalloproteinase domain-containing protein 17.	Amyloid beta A4 protein isoform X1.	0.616
Aif1	App	ENSDORP00000020316	ENSDORP00000025489	Allograft inflammatory factor 1 isoform X1.	Amyloid beta A4 protein isoform X1.	0.401
Aif1	Pycard	ENSDORP00000020316	ENSDORP00000022679	Allograft inflammatory factor 1 isoform X1.	Apoptosis-associated speck-like protein containing a CARD.	0.457
Aif1	Spn	ENSDORP00000020316	ENSDORP00000010744	Allograft inflammatory factor 1 isoform X1.	Leukosialin.	0.427
App	Adam10	ENSDORP00000025489	ENSDORP00000006997	Amyloid beta A4 protein isoform X1.	Disintegrin and metalloproteinase domain-containing protein 10.	0.785
App	Adam17	ENSDORP00000025489	ENSDORP00000013418	Amyloid beta A4 protein isoform X1.	Disintegrin and metalloproteinase domain-containing protein 17.	0.616
App	Aif1	ENSDORP00000025489	ENSDORP00000020316	Amyloid beta A4 protein isoform X1.	Allograft inflammatory factor 1 isoform X1.	0.401
App	Itga4	ENSDORP00000025489	ENSDORP00000018985	Amyloid beta A4 protein isoform X1.	Integrin alpha-4; Belongs to the integrin alpha chain family.	0.466
App	Itgb3	ENSDORP00000025489	ENSDORP00000015441	Amyloid beta A4 protein isoform X1.	Integrin beta; Belongs to the integrin beta chain family.	0.556
Ccl20	Ccl27	ENSDORP00000020672	ENSDORP00000027104	C-C motif chemokine.	C-C motif chemokine 27.	0.708
Ccl20	Ccr2	ENSDORP00000020672	ENSDORP00000024984	C-C motif chemokine.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.770
Ccl20	Ccr6	ENSDORP00000020672	ENSDORP00000011843	C-C motif chemokine.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.933
Ccl20	Cxcl12	ENSDORP00000020672	ENSDORP00000019495	C-C motif chemokine.	Stromal cell-derived factor 1 isoform X2; Belongs to the intercrine alpha (chemokine CxC) family.	0.733
Ccl21	Ccl27	ENSDORP00000002350	ENSDORP00000027104	C-C motif chemokine 21.	C-C motif chemokine 27.	0.865