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Dlg4 Dlg4 Wnt5a Wnt5a Pfn1 Pfn1 Adam22 Adam22 Grin2d Grin2d Cacna1a Cacna1a Grm7 Grm7 Shisa6 Shisa6 Tnik Tnik Ghrl Ghrl ENSDORP00000016518 ENSDORP00000016518 Ctbp2 Ctbp2 Ntrk3 Ntrk3 Htt Htt Ptprd Ptprd Nptx2 Nptx2 ENSDORP00000021001 ENSDORP00000021001 Mpp2 Mpp2 Lrrtm2 Lrrtm2 Drd3 Drd3 Rtn4r Rtn4r Grik5 Grik5 Cplx1 Cplx1 Lrrc4b Lrrc4b Arc Arc Iqsec1 Iqsec1 P2rx6 P2rx6 Plcb1 Plcb1 Adgrl3 Adgrl3 Iqsec2 Iqsec2 Cacng8 Cacng8 LOC106002162 LOC106002162 Mapk10 Mapk10 Grik1 Grik1 Ptprz1 Ptprz1 Ptk2b Ptk2b Dlg2 Dlg2 Cacng2 Cacng2 Cacng4 Cacng4 Efnb2 Efnb2 Grin2a Grin2a Grid2 Grid2 Homer2 Homer2 Snap23 Snap23 Grin3a Grin3a Grik3 Grik3 Ephb2 Ephb2 ENSDORP00000011621 ENSDORP00000011621 Erbb4 Erbb4 Stxbp1 Stxbp1 Grip1 Grip1 Dlg3 Dlg3 Fxr2 Fxr2 Ppp1r1b Ppp1r1b Rac1 Rac1 Grip2 Grip2 Dlg1 Dlg1 Synj1 Synj1 Gabrd Gabrd Adgrl1 Adgrl1 Ncam1 Ncam1 Ophn1 Ophn1 Slc6a7 Slc6a7 Tenm2 Tenm2 Slc6a15 Slc6a15 Lrrc7 Lrrc7 Stx1a Stx1a Cacna2d1 Cacna2d1 Cdkl5 Cdkl5 Gabbr2 Gabbr2 Syn3 Syn3 Adam23 Adam23 Nptx1 Nptx1 Kcnma1 Kcnma1 Gsg1l Gsg1l Lrrc4c Lrrc4c Syngap1 Syngap1 Nrxn1 Nrxn1 Gria1 Gria1 ENSDORP00000002242 ENSDORP00000002242 Dnm3 Dnm3 Cnih2 Cnih2 Cdh9 Cdh9 Magi2 Magi2 Rtn4 Rtn4 Gria3 Gria3 Mtor Mtor Grm3 Grm3 Slc1a6 Slc1a6 Kcna3 Kcna3 Gria2 Gria2 Rgs7 Rgs7 Git1 Git1 Epha4 Epha4 Synpo Synpo Stx3 Stx3 Kalrn Kalrn Mapk8ip2 Mapk8ip2 Cacng5 Cacng5 Slc6a17 Slc6a17 Ntng1 Ntng1 Grm8 Grm8 Ptprs Ptprs Chrm2 Chrm2 Il1rapl1 Il1rapl1 Erc1 Erc1 Ppfia2 Ppfia2 Dlgap3 Dlgap3 Scn8a Scn8a Camk2b Camk2b Ntrk2 Ntrk2 Lrrtm3 Lrrtm3 Cdh8 Cdh8 Slc1a7 Slc1a7 Cnr1 Cnr1 Agrn Agrn Lrfn5 Lrfn5 Pcdh8 Pcdh8 Flrt3 Flrt3 Dbn1 Dbn1 Grik4 Grik4 Dlgap4 Dlgap4 Rhoa Rhoa Nrg1 Nrg1 Unc13a Unc13a Camk2a Camk2a Dtnbp1 Dtnbp1 Chrm1 Chrm1 ENSDORP00000027710 ENSDORP00000027710 Dlgap1 Dlgap1 Lgi1 Lgi1 Lrrtm1 Lrrtm1 Cadm1 Cadm1 Clstn1 Clstn1 Lrrtm4 Lrrtm4 Adgrl2 Adgrl2 ENSDORP00000026247 ENSDORP00000026247 Mecp2 Mecp2 Calb1 Calb1 Sema3f Sema3f Efnb1 Efnb1 Shisa7 Shisa7 ENSDORP00000025126 ENSDORP00000025126 LOC105994487 LOC105994487 Cttn Cttn Efnb3 Efnb3 Prrt2 Prrt2 Cbln1 Cbln1 Arhgap44 Arhgap44 Stat3 Stat3 Fxr1 Fxr1 Shisa9 Shisa9 Baiap2 Baiap2 LOC105994343 LOC105994343 Slitrk1 Slitrk1 Cplx2 Cplx2 Shank3 Shank3 Gsk3b Gsk3b Syt7 Syt7 Gpc4 Gpc4 ENSDORP00000022835 ENSDORP00000022835 Ppp3cc Ppp3cc Grin1 Grin1 Clstn3 Clstn3 Chrm4 Chrm4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Dlg4Disks large homolog 4; Belongs to the MAGUK family. (657 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Pfn1Profilin; Belongs to the profilin family. (140 aa)
Adam22Disintegrin and metalloproteinase domain-containing protein 22 isoform X2. (929 aa)
Grin2dGlutamate receptor, ionotropic, NMDA2D (epsilon 4). (1128 aa)
Cacna1aVoltage-dependent P/Q-type calcium channel subunit alpha-1A. (2254 aa)
Grm7Metabotropic glutamate receptor 7 isoform X1. (918 aa)
Shisa6Protein shisa-6 homolog. (455 aa)
TnikTRAF2 and NCK-interacting protein kinase. (1315 aa)
GhrlAppetite-regulating hormone isoform X1. (125 aa)
ENSDORP00000016518annotation not available (92 aa)
Ctbp2C-terminal-binding protein 2 isoform X2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
Ntrk3Tyrosine-protein kinase receptor. (864 aa)
HttHuntingtin. (3048 aa)
PtprdReceptor-type tyrosine-protein phosphatase delta isoform X3. (1912 aa)
Nptx2Neuronal pentraxin-2. (397 aa)
ENSDORP00000021001annotation not available (353 aa)
Mpp2MAGUK p55 subfamily member 2; Belongs to the MAGUK family. (569 aa)
Lrrtm2Leucine-rich repeat transmembrane neuronal protein 2 isoform X1. (517 aa)
Drd3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
Rtn4rReticulon-4 receptor. (469 aa)
Grik5Glutamate receptor ionotropic, kainate 5. (985 aa)
Cplx1Complexin-1. (134 aa)
Lrrc4bLeucine-rich repeat-containing protein 4B. (669 aa)
ArcActivity-regulated cytoskeleton-associated protein. (396 aa)
Iqsec1IQ motif and SEC7 domain-containing protein 1 isoform X1. (1084 aa)
P2rx6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (396 aa)
Plcb11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
Adgrl3Latrophilin-3; Belongs to the G-protein coupled receptor 2 family. (1580 aa)
Iqsec2IQ motif and SEC7 domain-containing protein 2 isoform X1. (1488 aa)
Cacng8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (415 aa)
LOC106002162Disks large homolog 4-like. (150 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Grik1Glutamate receptor ionotropic, kainate 1 isoform X1. (926 aa)
Ptprz1Receptor-type tyrosine-protein phosphatase zeta. (2286 aa)
Ptk2bProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
Dlg2Disks large homolog 2 isoform X3. (870 aa)
Cacng2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (295 aa)
Cacng4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
Efnb2ephrin-B2; Belongs to the ephrin family. (325 aa)
Grin2aGlutamate receptor ionotropic, NMDA 2A. (1301 aa)
Grid2Glutamate receptor ionotropic, delta-2 isoform X1. (977 aa)
Homer2Homer protein homolog 2 isoform X2. (355 aa)
Snap23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
Grin3aGlutamate receptor ionotropic, NMDA 3A isoform X1. (1134 aa)
Grik3Glutamate receptor ionotropic, kainate 3 isoform X1. (919 aa)
Ephb2Ephrin type-B receptor 2 isoform X2. (1018 aa)
ENSDORP00000011621annotation not available (186 aa)
Erbb4Receptor protein-tyrosine kinase. (1308 aa)
Stxbp1Syntaxin-binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
Grip1Glutamate receptor-interacting protein 1. (1082 aa)
Dlg3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (849 aa)
Fxr2Fragile X mental retardation syndrome-related protein 2. (647 aa)
Ppp1r1bProtein phosphatase 1 regulatory subunit 1B. (192 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Grip2Glutamate receptor-interacting protein 2. (1042 aa)
Dlg1Disks large homolog 1; Belongs to the MAGUK family. (834 aa)
Synj1Synaptojanin-1 isoform X2. (693 aa)
GabrdGamma-aminobutyric acid receptor subunit delta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (449 aa)
Adgrl1Latrophilin-1; Belongs to the G-protein coupled receptor 2 family. (1041 aa)
Ncam1Neural cell adhesion molecule 1. (848 aa)
Ophn1Oligophrenin-1. (782 aa)
Slc6a7Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (625 aa)
Tenm2Teneurin-2 isoform X3. (2765 aa)
Slc6a15Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (731 aa)
Lrrc7Leucine-rich repeat-containing protein 7. (1514 aa)
Stx1asyntaxin-1A; Belongs to the syntaxin family. (288 aa)
Cacna2d1Voltage-dependent calcium channel subunit alpha-2/delta-1. (1079 aa)
Cdkl5Cyclin-dependent kinase-like 5. (945 aa)
Gabbr2Gamma-aminobutyric acid type B receptor subunit 2. (954 aa)
Syn3Synapsin-3 isoform X2. (323 aa)
Adam23Disintegrin and metalloproteinase domain-containing protein 23. (820 aa)
Nptx1Neuronal pentraxin-1. (284 aa)
Kcnma1Calcium-activated potassium channel subunit alpha-1. (1132 aa)
Gsg1lGerm cell-specific gene 1-like protein. (215 aa)
Lrrc4cLeucine-rich repeat-containing protein 4C. (640 aa)
Syngap1ras/Rap GTPase-activating protein SynGAP. (1343 aa)
Nrxn1Neurexin-1-beta isoform X1. (1515 aa)
Gria1Glutamate receptor 1 isoform X2. (906 aa)
ENSDORP00000002242annotation not available (278 aa)
Dnm3Dynamin-3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (845 aa)
Cnih2Protein cornichon homolog 2 isoform X2. (160 aa)
Cdh9Cadherin-9; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
Magi2Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2. (848 aa)
Rtn4Reticulon. (1108 aa)
Gria3Glutamate receptor 3 isoform X2. (894 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Grm3Metabotropic glutamate receptor 3. (882 aa)
Slc1a6Amino acid transporter. (544 aa)
Kcna3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (509 aa)
Gria2Glutamate receptor 2. (842 aa)
Rgs7Regulator of G-protein signaling 7 isoform X3. (477 aa)
Git1ARF GTPase-activating protein GIT1. (758 aa)
Epha4Ephrin type-A receptor 4 isoform X1. (986 aa)
SynpoSynaptopodin isoform X1. (926 aa)
Stx3Syntaxin-3; Belongs to the syntaxin family. (286 aa)
KalrnKalirin isoform X2. (2981 aa)
Mapk8ip2C-Jun-amino-terminal kinase-interacting protein 2. (804 aa)
Cacng5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
Slc6a17Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (727 aa)
Ntng1netrin-G1 isoform X1. (543 aa)
Grm8Metabotropic glutamate receptor 8 isoform X1. (908 aa)
PtprsReceptor-type tyrosine-protein phosphatase S. (1430 aa)
Chrm2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
Il1rapl1Interleukin-1 receptor accessory protein-like 1. (696 aa)
Erc1ELKS/Rab6-interacting/CAST family member 1 isoform X2. (1117 aa)
Ppfia2Liprin-alpha-2 isoform X1. (1257 aa)
Dlgap3Disks large-associated protein 3. (980 aa)
Scn8aSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1982 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta. (644 aa)
Ntrk2Tyrosine-protein kinase receptor. (821 aa)
Lrrtm3Leucine-rich repeat transmembrane neuronal protein 3. (581 aa)
Cdh8Cadherin-8 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (799 aa)
Slc1a7Amino acid transporter. (558 aa)
Cnr1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (471 aa)
AgrnAgrin. (1984 aa)
Lrfn5Leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1. (719 aa)
Pcdh8Protocadherin-8 isoform X1. (1072 aa)
Flrt3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
Dbn1Drebrin. (169 aa)
Grik4Glutamate receptor ionotropic, kainate 4. (765 aa)
Dlgap4Disks large-associated protein 4 isoform X1. (994 aa)
RhoaTransforming protein RhoA. (193 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
Unc13aProtein unc-13 homolog A. (1701 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (488 aa)
Dtnbp1Dysbindin. (330 aa)
Chrm1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
ENSDORP00000027710annotation not available (102 aa)
Dlgap1Disks large-associated protein 1 isoform X1. (993 aa)
Lgi1Leucine-rich glioma-inactivated protein 1 isoform X1. (557 aa)
Lrrtm1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
Cadm1Cell adhesion molecule 1 isoform X1. (474 aa)
Clstn1Calsyntenin-1. (970 aa)
Lrrtm4Leucine-rich repeat transmembrane neuronal protein 4 isoform X2. (519 aa)
Adgrl2Latrophilin-2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1487 aa)
ENSDORP00000026247annotation not available (399 aa)
Mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (500 aa)
Calb1Calbindin. (261 aa)
Sema3fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
Efnb1ephrin-B1; Belongs to the ephrin family. (345 aa)
Shisa7Protein shisa-7. (380 aa)
ENSDORP00000025126annotation not available (255 aa)
LOC105994487Ephrin type-B receptor 1-like. (304 aa)
CttnSrc substrate cortactin isoform X1. (550 aa)
Efnb3ephrin-B3; Belongs to the ephrin family. (340 aa)
Prrt2Proline-rich transmembrane protein 2. (61 aa)
Cbln1Cerebellin-1. (193 aa)
Arhgap44Rho GTPase-activating protein 44. (813 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Fxr1Fragile X mental retardation syndrome-related protein 1. (601 aa)
Shisa9Protein shisa-9 isoform X1. (426 aa)
Baiap2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (517 aa)
LOC105994343Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (224 aa)
Slitrk1SLIT and NTRK-like protein 1. (695 aa)
Cplx2Complexin-2. (134 aa)
Shank3SH3 and multiple ankyrin repeat domains protein 3. (1417 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
Syt7Synaptotagmin 7. (556 aa)
Gpc4Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
ENSDORP00000022835annotation not available (193 aa)
Ppp3ccSerine/threonine-protein phosphatase. (478 aa)
Grin1LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1. (926 aa)
Clstn3Calsyntenin-3. (948 aa)
Chrm4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (479 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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