50 items (Dipodomys ordii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Rhoa	Transforming protein RhoA. (193 aa)
	Prkcd	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	ENSDORP00000019733	annotation not available (100 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	LOC105993014	ubiquitin-40S ribosomal protein S27a pseudogene. (147 aa)
	Kras	Kirsten rat sarcoma viral oncogene homolog. (163 aa)
	Cdc37	Hsp90 co-chaperone Cdc37. (378 aa)
	Uba52	ubiquitin-60S ribosomal protein L40. (128 aa)
	LOC105986631	Ubiquitin-like. (77 aa)
	Nras	GTPase NRas. (189 aa)
	ENSDORP00000022835	annotation not available (193 aa)
	Erbin	Protein LAP2 isoform X1. (1458 aa)
	Hras	GTPase HRas isoform X1. (192 aa)
	Erbb3	Receptor tyrosine-protein kinase erbB-3. (1339 aa)
	Egf	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
	Fndc3a	Fibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
	Grb7	Growth factor receptor-bound protein 7. (531 aa)
	Matk	Tyrosine-protein kinase. (484 aa)
	Akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	Akt3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	Grb2	Growth factor receptor-bound protein 2. (217 aa)
	Src	Tyrosine-protein kinase. (539 aa)
	Btc	Probetacellulin. (163 aa)
	Gab1	GRB2-associated-binding protein 1. (707 aa)
	Erbb2	Receptor protein-tyrosine kinase. (1255 aa)
	Egfr	Receptor protein-tyrosine kinase. (1215 aa)
	Erbb4	Receptor protein-tyrosine kinase. (1308 aa)
	Rnf41	E3 ubiquitin-protein ligase NRDP1. (317 aa)
	Hbegf	Proheparin-binding EGF-like growth factor. (206 aa)
	ENSDORP00000011621	annotation not available (186 aa)
	Csde1	Cold shock domain-containing protein E1 isoform X1. (798 aa)
	Kras-2	GTPase KRas isoform X4. (189 aa)
	Ptpn18	Tyrosine-protein phosphatase non-receptor type 18 isoform X1. (455 aa)
	Prkce	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (548 aa)
	Memo1	Protein MEMO1. (292 aa)
	Pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	Ereg	Proepiregulin. (163 aa)
	Cul5	Cullin-5; Belongs to the cullin family. (751 aa)
	Stub1	E3 ubiquitin-protein ligase CHIP. (267 aa)
	Rps27a	ubiquitin-40S ribosomal protein S27a. (156 aa)
	Akt1	Non-specific serine/threonine protein kinase. (188 aa)
	Ptk6	Tyrosine-protein kinase. (451 aa)
	Shc1	SHC-transforming protein 1 isoform X2. (473 aa)
	Yes1	Tyrosine-protein kinase. (541 aa)
	Nrg4	Pro-neuregulin-4, membrane-bound isoform. (110 aa)
	ENSDORP00000002242	annotation not available (278 aa)
	Sos1	Son of sevenless homolog 1. (1301 aa)
	Nrg3	Pro-neuregulin-3, membrane-bound isoform. (680 aa)
	Nrg1	Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
	Usp8	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1018 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Akt2	ENSDORP00000005559	ENSDORP00000026851	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.967
Akt1	Akt3	ENSDORP00000005559	ENSDORP00000027572	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.911
Akt1	Cdc37	ENSDORP00000005559	ENSDORP00000021519	Non-specific serine/threonine protein kinase.	Hsp90 co-chaperone Cdc37.	0.969
Akt1	Csde1	ENSDORP00000005559	ENSDORP00000010910	Non-specific serine/threonine protein kinase.	Cold shock domain-containing protein E1 isoform X1.	0.571
Akt1	ENSDORP00000011621	ENSDORP00000005559	ENSDORP00000011621	Non-specific serine/threonine protein kinase.	annotation not available	0.621
Akt1	ENSDORP00000022835	ENSDORP00000005559	ENSDORP00000022835	Non-specific serine/threonine protein kinase.	annotation not available	0.621
Akt1	Egf	ENSDORP00000005559	ENSDORP00000000459	Non-specific serine/threonine protein kinase.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.603
Akt1	Egfr	ENSDORP00000005559	ENSDORP00000012273	Non-specific serine/threonine protein kinase.	Receptor protein-tyrosine kinase.	0.757
Akt1	Erbb2	ENSDORP00000005559	ENSDORP00000013983	Non-specific serine/threonine protein kinase.	Receptor protein-tyrosine kinase.	0.516
Akt1	Erbb3	ENSDORP00000005559	ENSDORP00000001013	Non-specific serine/threonine protein kinase.	Receptor tyrosine-protein kinase erbB-3.	0.667
Akt1	Erbb4	ENSDORP00000005559	ENSDORP00000012249	Non-specific serine/threonine protein kinase.	Receptor protein-tyrosine kinase.	0.554
Akt1	Gab1	ENSDORP00000005559	ENSDORP00000014961	Non-specific serine/threonine protein kinase.	GRB2-associated-binding protein 1.	0.466
Akt1	Grb2	ENSDORP00000005559	ENSDORP00000027785	Non-specific serine/threonine protein kinase.	Growth factor receptor-bound protein 2.	0.750
Akt1	Hras	ENSDORP00000005559	ENSDORP00000025523	Non-specific serine/threonine protein kinase.	GTPase HRas isoform X1.	0.571
Akt1	Kras	ENSDORP00000005559	ENSDORP00000021115	Non-specific serine/threonine protein kinase.	Kirsten rat sarcoma viral oncogene homolog.	0.571
Akt1	Kras-2	ENSDORP00000005559	ENSDORP00000010780	Non-specific serine/threonine protein kinase.	GTPase KRas isoform X4.	0.666
Akt1	LOC105986631	ENSDORP00000005559	ENSDORP00000022383	Non-specific serine/threonine protein kinase.	Ubiquitin-like.	0.501
Akt1	Matk	ENSDORP00000005559	ENSDORP00000026570	Non-specific serine/threonine protein kinase.	Tyrosine-protein kinase.	0.591
Akt1	Nras	ENSDORP00000005559	ENSDORP00000022462	Non-specific serine/threonine protein kinase.	GTPase NRas.	0.626
Akt1	Nrg1	ENSDORP00000005559	ENSDORP00000018178	Non-specific serine/threonine protein kinase.	Pro-neuregulin-1, membrane-bound isoform isoform X1.	0.423