STRINGSTRING
Nab1 Nab1 Dock3 Dock3 Ppp2ca Ppp2ca Chd4 Chd4 Crkl Crkl Kras Kras Egr2 Egr2 Grb2 Grb2 Mapkapk3 Mapkapk3 Ywhab Ywhab Fnbp4 Fnbp4 Egr1 Egr1 Ralgds Ralgds Hras Hras Egr4 Egr4 Nab2 Nab2 Id4 Id4 Dusp6 Dusp6 ENSDORP00000024608 ENSDORP00000024608 Relch Relch Mapk14 Mapk14 ENSDORP00000024250 ENSDORP00000024250 Dusp3 Dusp3 ENSDORP00000023068 ENSDORP00000023068 Rala Rala ENSDORP00000022835 ENSDORP00000022835 Nras Nras Map2k5 Map2k5 Bdnf Bdnf Crk Crk Ntf4 Ntf4 Ngf Ngf Pcsk4 Pcsk4 Id2 Id2 Kidins220 Kidins220 Ap2a1 Ap2a1 Ap2s1 Ap2s1 Mapk7 Mapk7 Dnal4 Dnal4 Ntf3 Ntf3 Ntrk3 Ntrk3 Pcsk6 Pcsk6 Mapk1 Mapk1 Dusp4 Dusp4 Cdk5r2 Cdk5r2 Lyl1 Lyl1 Arc Arc Mapkapk2 Mapkapk2 Braf Braf Ap2m1 Ap2m1 Rhoa Rhoa Frs2 Frs2 Trib1 Trib1 Trib2 Trib2 Sgk1 Sgk1 Nkpd1 Nkpd1 LOC106001914 LOC106001914 Pik3r1 Pik3r1 Fndc3a Fndc3a Sh3gl2 Sh3gl2 Srf Srf Egr3 Egr3 Elk1 Elk1 Map2k2 Map2k2 Map2k1 Map2k1 Shc2 Shc2 Sos1 Sos1 Vrk3 Vrk3 Mapk3 Mapk3 Rapgef1 Rapgef1 Ppp4r4 Ppp4r4 Shc1 Shc1 Ap2b1 Ap2b1 Pcsk5 Pcsk5 Ppp4r1 Ppp4r1 Mast3 Mast3 Clta Clta Ntrk1 Ntrk1 Shc3 Shc3 Ap2a2 Ap2a2 Id3 Id3 Pik3cb Pik3cb Dusp7 Dusp7 Cltc Cltc Rps6ka1 Rps6ka1 Rps6ka5 Rps6ka5 Ntrk2 Ntrk2 Rps6ka2 Rps6ka2 Ppp2cb Ppp2cb Atf1 Atf1 Fosb Fosb Ppp2r1b Ppp2r1b Rit2 Rit2 Pik3ca Pik3ca Fosl1 Fosl1 Shc4 Shc4 Kras-2 Kras-2 Csde1 Csde1 Rap1a Rap1a Rps6ka3 Rps6ka3 Plcg1 Plcg1 Ppp2r5d Ppp2r5d Irs1 Irs1 ENSDORP00000011621 ENSDORP00000011621 Creb1 Creb1 Ralb Ralb Rrad Rrad Furin Furin Rac1 Rac1 Ppp2r1a Ppp2r1a Rit1 Rit1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Nab1NGFI-A-binding protein 1 isoform X1. (487 aa)
Dock3Dedicator of cytokinesis protein 3; Belongs to the DOCK family. (2017 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
Chd4chromodomain-helicase-DNA-binding protein 4 isoform X2. (1942 aa)
CrklCrk-like protein. (303 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Egr2E3 SUMO-protein ligase EGR2. (72 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Mapkapk3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (385 aa)
Ywhab14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
Fnbp4Formin-binding protein 4. (895 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
RalgdsRal guanine nucleotide dissociation stimulator isoform X2. (855 aa)
HrasGTPase HRas isoform X1. (192 aa)
Egr4LOW QUALITY PROTEIN: early growth response protein 4. (491 aa)
Nab2NGFI-A-binding protein 2 isoform X1. (525 aa)
Id4DNA-binding protein inhibitor ID-4. (161 aa)
Dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ENSDORP00000024608annotation not available (540 aa)
RelchlisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1221 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
ENSDORP00000024250annotation not available (95 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
ENSDORP00000023068annotation not available (544 aa)
RalaRas-related protein Ral-A. (206 aa)
ENSDORP00000022835annotation not available (193 aa)
NrasGTPase NRas. (189 aa)
Map2k5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (439 aa)
BdnfBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (255 aa)
CrkAdapter molecule crk. (304 aa)
Ntf4Neurotrophin 4. (210 aa)
NgfBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
Pcsk4Proprotein convertase subtilisin/kexin type 4. (432 aa)
Id2DNA-binding protein inhibitor ID-2. (116 aa)
Kidins220Kinase D-interacting substrate of 220 kDa isoform X1. (1782 aa)
Ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
Ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
Mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
Dnal4Dynein light chain. (105 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (261 aa)
Ntrk3Tyrosine-protein kinase receptor. (864 aa)
Pcsk6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (927 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (395 aa)
Cdk5r2Cyclin-dependent kinase 5 activator. (96 aa)
Lyl1Protein lyl-1. (237 aa)
ArcActivity-regulated cytoskeleton-associated protein. (396 aa)
Mapkapk2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (353 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Ap2m1AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (435 aa)
RhoaTransforming protein RhoA. (193 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Trib1Tribbles homolog 1. (141 aa)
Trib2Tribbles homolog 2. (343 aa)
Sgk1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
Nkpd1NTPase KAP family P-loop domain-containing protein 1. (603 aa)
LOC106001914Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Fndc3aFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
Sh3gl2endophilin-A1. (346 aa)
SrfSerum response factor. (508 aa)
Egr3Early growth response protein 3 isoform X1. (387 aa)
Elk1ETS domain-containing protein Elk-1. (430 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Shc2SHC-transforming protein 2. (513 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Vrk3Inactive serine/threonine-protein kinase VRK3. (453 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Rapgef1Rap guanine nucleotide exchange factor 1 isoform X1. (1198 aa)
Ppp4r4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (851 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Ap2b1AP complex subunit beta. (951 aa)
Pcsk5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (912 aa)
Ppp4r1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (376 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
CltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
Ntrk1Tyrosine-protein kinase receptor. (799 aa)
Shc3SHC-transforming protein 3. (598 aa)
Ap2a2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (916 aa)
Id3DNA-binding protein inhibitor ID-3. (119 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (383 aa)
CltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
Rps6ka1Non-specific serine/threonine protein kinase. (644 aa)
Rps6ka5Ribosomal protein S6 kinase. (768 aa)
Ntrk2Tyrosine-protein kinase receptor. (821 aa)
Rps6ka2Non-specific serine/threonine protein kinase. (705 aa)
Ppp2cbSerine/threonine-protein phosphatase. (309 aa)
Atf1Cyclic AMP-dependent transcription factor ATF-1. (219 aa)
FosbProtein fosB isoform X1. (332 aa)
Ppp2r1bProtein phosphatase 2 scaffold subunit Abeta. (584 aa)
Rit2GTP-binding protein Rit2. (217 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fosl1Fos-related antigen 1 isoform X1. (278 aa)
Shc4SHC-transforming protein 4. (340 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Rap1aRas-related protein Rap-1A. (178 aa)
Rps6ka3Ribosomal protein S6 kinase alpha-3. (654 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Ppp2r5dSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (592 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
ENSDORP00000011621annotation not available (186 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RalbRas-related protein Ral-B. (206 aa)
RradGTP-binding protein RAD. (296 aa)
FurinFurin; Belongs to the peptidase S8 family. (790 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Rit1GTP-binding protein Rit1 isoform X1. (183 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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