STRINGSTRING
Pik3r1 Pik3r1 Kl Kl Ppp2ca Ppp2ca Vav1 Vav1 Pdgfb Pdgfb Tgfa Tgfa Fgf9 Fgf9 Ins Ins LOC106000559 LOC106000559 Fgf18 Fgf18 Ier3 Ier3 Strn3 Strn3 Pip5k1a Pip5k1a Fgfr3-2 Fgfr3-2 Phlpp2 Phlpp2 Fgf5 Fgf5 Flt3lg Flt3lg Epgn Epgn Rac1 Rac1 Ppp2r1a Ppp2r1a Erbb2 Erbb2 Irak4 Irak4 Insc Insc Gab1 Gab1 Btc Btc Relch Relch Rhog Rhog Ppp2r5e Ppp2r5e Fgfr1 Fgfr1 Fgf20 Fgf20 Pik3cb Pik3cb Akt1 Akt1 Klb Klb ENSDORP00000024608 ENSDORP00000024608 Pdgfrb Pdgfrb Wdr64 Wdr64 Akt2 Akt2 Fnbp4 Fnbp4 Esr2 Esr2 Fgf4 Fgf4 Ppp2r5c Ppp2r5c Akt3 Akt3 Fgf16 Fgf16 Grb2 Grb2 Il1rap Il1rap Cd276 Cd276 ENSDORP00000024250 ENSDORP00000024250 Traf6 Traf6 Phlpp1 Phlpp1 Pik3r3 Pik3r3 Fgfr2 Fgfr2 Pip5k1b Pip5k1b Mapk1 Mapk1 Nrg3 Nrg3 Pip4k2c Pip4k2c Fgf7 Fgf7 ENSDORP00000023068 ENSDORP00000023068 Nrg1 Nrg1 Fgf1 Fgf1 Frs2 Frs2 Fgf6 Fgf6 Fgf2 Fgf2 Irak1 Irak1 Pip5k1c Pip5k1c Fgf8 Fgf8 Kit Kit Ppp2r5a Ppp2r5a Fgf10 Fgf10 Ppp2cb Ppp2cb Ptpn11 Ptpn11 Ereg Ereg Spem1 Spem1 Spem2 Spem2 Pten Pten Ppp2r1b Ppp2r1b Rac2 Rac2 Il33 Il33 Pik3ca Pik3ca Fgfr3 Fgfr3 Pip4k2b Pip4k2b Gab2 Gab2 Icos Icos Esr1 Esr1 Flt3 Flt3 Cd19 Cd19 Ppp2r5b Ppp2r5b Ppp2r5d Ppp2r5d Irs1 Irs1 Fgf17 Fgf17 Pik3cd Pik3cd Hbegf Hbegf Erbb4 Erbb4 Egfr Egfr Pip5kl1 Pip5kl1 Fam102a Fam102a Cd28 Cd28 Strn4 Strn4 Myd88 Myd88 Mast3 Mast3 Ppp4r1 Ppp4r1 Trat1 Trat1 Areg Areg Fgf22 Fgf22 Pik3ap1 Pik3ap1 Ppp4r4 Ppp4r4 Pdgfa Pdgfa Mapk3 Mapk3 Bank1 Bank1 Nrg4 Nrg4 ENSDORP00000002242 ENSDORP00000002242 Strn Strn Trib3 Trib3 Pip4k2a Pip4k2a Erbb3 Erbb3 Lrrc40 Lrrc40 Egf Egf Fndc3a Fndc3a Il1rl1 Il1rl1 Hgf Hgf Kitl Kitl Met Met Pdgfra Pdgfra Fgfr4 Fgfr4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
KlKlotho. (1020 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
Vav1Proto-oncogene vav. (845 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TgfaProtransforming growth factor alpha. (156 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
Ier3Radiation-inducible immediate-early gene IEX-1. (156 aa)
Strn3Striatin-3. (700 aa)
Pip5k1aPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha. (569 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
Phlpp2PH domain leucine-rich repeat-containing protein phosphatase 2. (1274 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
Flt3lgFms-related tyrosine kinase 3 ligand isoform X1. (181 aa)
EpgnEpigen isoform X5. (153 aa)
Rac1Ras-related C3 botulinum toxin substrate 1. (187 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
Irak4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
InscProtein inscuteable homolog. (577 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
BtcProbetacellulin. (163 aa)
RelchlisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1221 aa)
RhogRho-related GTP-binding protein RhoG. (191 aa)
Ppp2r5eSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (428 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
KlbBeta-klotho. (976 aa)
ENSDORP00000024608annotation not available (540 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
Wdr64WD repeat-containing protein 64. (1048 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Fnbp4Formin-binding protein 4. (895 aa)
Esr2Estrogen receptor beta. (550 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Ppp2r5cSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Il1rapInterleukin-1 receptor accessory protein isoform X1. (665 aa)
Cd276CD276 antigen. (310 aa)
ENSDORP00000024250annotation not available (95 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (529 aa)
Phlpp1PH domain leucine-rich repeat-containing protein phosphatase 1. (1448 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Pip5k1bPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3. (540 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Nrg3Pro-neuregulin-3, membrane-bound isoform. (680 aa)
Pip4k2cPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (421 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSDORP00000023068annotation not available (544 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Irak1Interleukin-1 receptor-associated kinase 1. (714 aa)
Pip5k1cLOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (976 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
KitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
Ppp2r5aSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (416 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
Ppp2cbSerine/threonine-protein phosphatase. (309 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
EregProepiregulin. (163 aa)
Spem1Spermatid maturation protein 1. (301 aa)
Spem2Uncharacterized protein C17orf74 homolog. (489 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Ppp2r1bProtein phosphatase 2 scaffold subunit Abeta. (584 aa)
Rac2Ras-related C3 botulinum toxin substrate 2. (184 aa)
Il33Interleukin-33. (250 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
Pip4k2bPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (400 aa)
Gab2GRB2-associated-binding protein 2. (608 aa)
IcosInducible T-cell costimulator isoform X1. (202 aa)
Esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
Flt3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
Cd19B-lymphocyte antigen CD19. (538 aa)
Ppp2r5bSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform. (256 aa)
Ppp2r5dSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (592 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
HbegfProheparin-binding EGF-like growth factor. (206 aa)
Erbb4Receptor protein-tyrosine kinase. (1308 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Pip5kl1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (387 aa)
Fam102aProtein FAM102A. (385 aa)
Cd28T-cell-specific surface glycoprotein CD28. (219 aa)
Strn4Striatin-4. (634 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (338 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Ppp4r1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (376 aa)
Trat1T-cell receptor-associated transmembrane adapter 1. (196 aa)
AregAmphiregulin. (245 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Pik3ap1Phosphoinositide 3-kinase adapter protein 1. (806 aa)
Ppp4r4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (851 aa)
PdgfaPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (210 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Bank1B-cell scaffold protein with ankyrin repeats. (783 aa)
Nrg4Pro-neuregulin-4, membrane-bound isoform. (110 aa)
ENSDORP00000002242annotation not available (278 aa)
StrnStriatin. (771 aa)
Trib3Tribbles homolog 3. (357 aa)
Pip4k2aPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (405 aa)
Erbb3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
Lrrc40Leucine-rich repeat-containing protein 40 isoform X1. (602 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Fndc3aFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
Il1rl1Interleukin-1 receptor-like 1. (538 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
KitlKit ligand. (231 aa)
MetHepatocyte growth factor receptor. (1382 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
Fgfr4Fibroblast growth factor receptor. (766 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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