STRINGSTRING
Gab2 Gab2 Grb2 Grb2 Fgf16 Fgf16 Fgf4 Fgf4 Akt2 Akt2 Pik3r4-2 Pik3r4-2 Fgf8 Fgf8 Insr Insr Fgfr1 Fgfr1 Fgfr3-2 Fgfr3-2 Fgf18 Fgf18 Fgf9 Fgf9 Igf2 Igf2 Pde3b Pde3b Kl Kl Pik3r1 Pik3r1 Fgfr4 Fgfr4 Fgf2 Fgf2 Fgf6 Fgf6 Frs2 Frs2 Fgf1 Fgf1 Fgf7 Fgf7 Fgfr2 Fgfr2 Gab1 Gab1 Pik3c3 Pik3c3 Cilp Cilp Flt3lg Flt3lg Fgf5 Fgf5 Tlr9 Tlr9 Irs4 Irs4 Fgf17 Fgf17 Irs1 Irs1 Pdpk1 Pdpk1 Flt3 Flt3 Igf1 Igf1 Trib3 Trib3 Sos1 Sos1 Shc1 Shc1 Fgf22 Fgf22 Mast3 Mast3 Igf1r Igf1r Pik3r4 Pik3r4 Klb Klb Pik3cb Pik3cb Fgf20 Fgf20 Fgf10 Fgf10 Ptpn11 Ptpn11 Spem1 Spem1 Spem2 Spem2 Pik3ca Pik3ca Fgfr3 Fgfr3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gab2GRB2-associated-binding protein 2. (608 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r4-2Phosphoinositide 3-kinase regulatory subunit 4. (296 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Igf2Insulin-like growth factor II. (176 aa)
Pde3bPhosphodiesterase. (1011 aa)
KlKlotho. (1020 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Fgfr4Fibroblast growth factor receptor. (766 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
CilpCartilage intermediate layer protein 1. (888 aa)
Flt3lgFms-related tyrosine kinase 3 ligand isoform X1. (181 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
Tlr9Toll-like receptor 9 isoform X3. (1029 aa)
Irs4Insulin receptor substrate 4. (1262 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Flt3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
Trib3Tribbles homolog 3. (357 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Pik3r4Phosphoinositide-3-kinase regulatory subunit 4. (208 aa)
KlbBeta-klotho. (976 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Spem1Spermatid maturation protein 1. (301 aa)
Spem2Uncharacterized protein C17orf74 homolog. (489 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.