29 items (Dipodomys ordii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
	Fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	Grb2	Growth factor receptor-bound protein 2. (217 aa)
	Sos1	Son of sevenless homolog 1. (1301 aa)
	Shc1	SHC-transforming protein 1 isoform X2. (473 aa)
	Fgf22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	Fgf10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	Ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
	Pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	Kras-2	GTPase KRas isoform X4. (189 aa)
	Csde1	Cold shock domain-containing protein E1 isoform X1. (798 aa)
	Plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
	Fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	Fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
	Gab1	GRB2-associated-binding protein 1. (707 aa)
	Fgfr2	Fibroblast growth factor receptor. (819 aa)
	Fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	Fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	Frs2	Fibroblast growth factor receptor substrate 2. (507 aa)
	Fgf6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
	Fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	Kras	Kirsten rat sarcoma viral oncogene homolog. (163 aa)
	Fgf9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	Fgf18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
	Nras	GTPase NRas. (189 aa)
	Fgf8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
	Hras	GTPase HRas isoform X1. (192 aa)

Your Current Organism:

Dipodomys ordii

NCBI taxonomy Id: 10020
Other names: D. ordii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Csde1	Fgf1	ENSDORP00000010910	ENSDORP00000018210	Cold shock domain-containing protein E1 isoform X1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.447
Csde1	Fgf10	ENSDORP00000010910	ENSDORP00000007202	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
Csde1	Fgf16	ENSDORP00000010910	ENSDORP00000027749	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.434
Csde1	Fgf17	ENSDORP00000010910	ENSDORP00000011629	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.450
Csde1	Fgf18	ENSDORP00000010910	ENSDORP00000021919	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.538
Csde1	Fgf2	ENSDORP00000010910	ENSDORP00000018667	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.440
Csde1	Fgf20	ENSDORP00000010910	ENSDORP00000006443	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.434
Csde1	Fgf22	ENSDORP00000010910	ENSDORP00000003602	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
Csde1	Fgf4	ENSDORP00000010910	ENSDORP00000027125	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
Csde1	Fgf5	ENSDORP00000010910	ENSDORP00000012678	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.441
Csde1	Fgf6	ENSDORP00000010910	ENSDORP00000018613	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.434
Csde1	Fgf7	ENSDORP00000010910	ENSDORP00000018162	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
Csde1	Fgf8	ENSDORP00000010910	ENSDORP00000024282	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
Csde1	Fgf9	ENSDORP00000010910	ENSDORP00000021571	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.434
Csde1	Fgfr2	ENSDORP00000010910	ENSDORP00000016679	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor receptor.	0.774
Csde1	Frs2	ENSDORP00000010910	ENSDORP00000018239	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor receptor substrate 2.	0.596
Csde1	Gab1	ENSDORP00000010910	ENSDORP00000014961	Cold shock domain-containing protein E1 isoform X1.	GRB2-associated-binding protein 1.	0.561
Csde1	Grb2	ENSDORP00000010910	ENSDORP00000027785	Cold shock domain-containing protein E1 isoform X1.	Growth factor receptor-bound protein 2.	0.790
Csde1	Hras	ENSDORP00000010910	ENSDORP00000025523	Cold shock domain-containing protein E1 isoform X1.	GTPase HRas isoform X1.	0.431
Csde1	Kras	ENSDORP00000010910	ENSDORP00000021115	Cold shock domain-containing protein E1 isoform X1.	Kirsten rat sarcoma viral oncogene homolog.	0.431