STRINGSTRING
Fgf5 Fgf5 Fgf1 Fgf1 Gab1 Gab1 Frs2 Frs2 Fgf2 Fgf2 Pik3r1 Pik3r1 Fgf9 Fgf9 Fgf18 Fgf18 Fgfr3-2 Fgfr3-2 Fgf8 Fgf8 Fgf4 Fgf4 Fgf16 Fgf16 Grb2 Grb2 Fgf20 Fgf20 Ptpn11 Ptpn11 Pik3ca Pik3ca Fgfr3 Fgfr3 Fgf17 Fgf17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.