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Fgfr1 Fgfr1 Flrt1 Flrt1 Fgf2 Fgf2 Fgf6 Fgf6 Frs2 Frs2 Fgf1 Fgf1 Braf Braf Mapk1 Mapk1 Fndc3a Fndc3a Fgfrl1 Fgfrl1 Gab1 Gab1 Ppp2r1a Ppp2r1a Fgf5 Fgf5 Fgf17 Fgf17 Spred2 Spred2 Plcg1 Plcg1 Csde1 Csde1 Sos1 Sos1 Kras-2 Kras-2 Pik3ca Pik3ca Flrt3 Flrt3 Ptpn11 Ptpn11 Ppp2cb Ppp2cb Fgf10 Fgf10 Mknk1 Mknk1 Fgf20 Fgf20 Rps27a Rps27a Flrt2 Flrt2 Fgf22 Fgf22 Shc1 Shc1 Mapk3 Mapk3 Grb2 Grb2 Fgf4 Fgf4 Hras Hras ENSDORP00000024608 ENSDORP00000024608 Fgf8 Fgf8 Spred1 Spred1 ENSDORP00000023068 ENSDORP00000023068 Nras Nras LOC105986631 LOC105986631 Uba52 Uba52 Spry2 Spry2 Fgf18 Fgf18 Kras Kras LOC105993014 LOC105993014 Ppp2ca Ppp2ca Kl Kl Cbl Cbl Pik3r1 Pik3r1 ENSDORP00000019733 ENSDORP00000019733 Mknk2 Mknk2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Fgfr1Fibroblast growth factor receptor. (822 aa)
Flrt1Leucine-rich repeat transmembrane protein FLRT1. (674 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Fndc3aFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
Fgfrl1Fibroblast growth factor receptor-like 1. (489 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Spred2Sprouty-related, EVH1 domain-containing protein 2 isoform X2. (421 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Flrt3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Ppp2cbSerine/threonine-protein phosphatase. (309 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
Mknk1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (422 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Flrt2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
HrasGTPase HRas isoform X1. (192 aa)
ENSDORP00000024608annotation not available (540 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
Spred1Sprouty-related, EVH1 domain-containing protein 1. (436 aa)
ENSDORP00000023068annotation not available (544 aa)
NrasGTPase NRas. (189 aa)
LOC105986631Ubiquitin-like. (77 aa)
Uba52ubiquitin-60S ribosomal protein L40. (128 aa)
Spry2Protein sprouty homolog 2. (315 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
LOC105993014ubiquitin-40S ribosomal protein S27a pseudogene. (147 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
KlKlotho. (1020 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ENSDORP00000019733annotation not available (100 aa)
Mknk2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (464 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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