STRINGSTRING
Mapk1 Mapk1 Trib3 Trib3 Sos1 Sos1 Mapk3 Mapk3 Shc1 Shc1 Fgf22 Fgf22 Mast3 Mast3 Pik3r4 Pik3r4 Klb Klb Pik3cb Pik3cb Fgf20 Fgf20 Fgf10 Fgf10 Ptpn11 Ptpn11 Spem1 Spem1 Spem2 Spem2 Pik3ca Pik3ca Fgfr3 Fgfr3 Gab2 Gab2 Flt3 Flt3 Pdpk1 Pdpk1 Irs1 Irs1 Fgf17 Fgf17 Tlr9 Tlr9 Fgf5 Fgf5 Flt3lg Flt3lg Pik3c3 Pik3c3 Grb10 Grb10 Grb2 Grb2 Fgf16 Fgf16 Fgf4 Fgf4 Akt2 Akt2 Pik3r4-2 Pik3r4-2 Fgf8 Fgf8 Fgfr1 Fgfr1 Fgfr3-2 Fgfr3-2 Fgf18 Fgf18 Ins Ins Fgf9 Fgf9 Pde3b Pde3b Gab1 Gab1 Kl Kl Pik3r1 Pik3r1 Fgfr4 Fgfr4 Fgf2 Fgf2 Fgf6 Fgf6 Frs2 Frs2 Fgf1 Fgf1 Fgf7 Fgf7 Fgfr2 Fgfr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Trib3Tribbles homolog 3. (357 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Pik3r4Phosphoinositide-3-kinase regulatory subunit 4. (208 aa)
KlbBeta-klotho. (976 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Spem1Spermatid maturation protein 1. (301 aa)
Spem2Uncharacterized protein C17orf74 homolog. (489 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
Gab2GRB2-associated-binding protein 2. (608 aa)
Flt3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Tlr9Toll-like receptor 9 isoform X3. (1029 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
Flt3lgFms-related tyrosine kinase 3 ligand isoform X1. (181 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
Grb10Growth factor receptor-bound protein 10 isoform X2. (541 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r4-2Phosphoinositide 3-kinase regulatory subunit 4. (296 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Pde3bPhosphodiesterase. (1011 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
KlKlotho. (1020 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Fgfr4Fibroblast growth factor receptor. (766 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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