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Akt2 Akt2 Pik3r4-2 Pik3r4-2 Atp6v0e1 Atp6v0e1 Ptpn1 Ptpn1 Atp6v1g1 Atp6v1g1 Fgf8 Fgf8 Fgfr1 Fgfr1 Atp6v0e2 Atp6v0e2 Atp6v0c Atp6v0c Fgfr3-2 Fgfr3-2 Fgf18 Fgf18 Ins Ins Fgf9 Fgf9 Atp6v1g2-2 Atp6v1g2-2 Pde3b Pde3b Kl Kl Atp6v1b2 Atp6v1b2 Pdpk1 Pdpk1 Flt3 Flt3 Gab2 Gab2 Fgfr3 Fgfr3 Cnst Cnst Pik3ca Pik3ca Spem2 Spem2 Spem1 Spem1 Ptpn11 Ptpn11 Fgf10 Fgf10 Fgf20 Fgf20 Atp6v1a Atp6v1a Pik3cb Pik3cb Ptprf Ptprf Klb Klb Pik3r4 Pik3r4 Atp6v0a4 Atp6v0a4 Lim2 Lim2 Mast3 Mast3 Fgf22 Fgf22 Shc1 Shc1 Mapk3 Mapk3 Nrd1 Nrd1 Sos1 Sos1 Trib3 Trib3 Atp6v1e1 Atp6v1e1 Atp6v1c2 Atp6v1c2 ENSDORP00000016454 ENSDORP00000016454 Fgfr2 Fgfr2 Mapk1 Mapk1 LOC105981036 LOC105981036 Fgf7 Fgf7 Fgf1 Fgf1 Frs2 Frs2 Atp6ap1l Atp6ap1l Fgf6 Fgf6 Fgf2 Fgf2 Atp6v1h Atp6v1h Fgfr4 Fgfr4 Pik3r1 Pik3r1 Atp6v1f Atp6v1f Atp6ap1 Atp6ap1 Atp6v0a2 Atp6v0a2 ENSDORP00000015961 ENSDORP00000015961 Grb2 Grb2 Atp6v1g3 Atp6v1g3 Fgf16 Fgf16 Atp6v1g2 Atp6v1g2 Atp6v0b Atp6v0b Atp6v0d2 Atp6v0d2 Gab1 Gab1 Grb10 Grb10 Pik3c3 Pik3c3 Atp6v1d Atp6v1d Atp6v1b1 Atp6v1b1 Atp6v1c1 Atp6v1c1 Fgf4 Fgf4 Atp6v0d1 Atp6v0d1 Flt3lg Flt3lg Fgf5 Fgf5 Atp6v0a1 Atp6v0a1 Ide Ide Tlr9 Tlr9 Tcirg1 Tcirg1 Fgf17 Fgf17 Irs1 Irs1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Pik3r4-2Phosphoinositide 3-kinase regulatory subunit 4. (296 aa)
Atp6v0e1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type. (436 aa)
Atp6v1g1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
Fgfr1Fibroblast growth factor receptor. (822 aa)
Atp6v0e2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
Atp6v0cV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (112 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (185 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Atp6v1g2-2V-type proton ATPase subunit G 2 isoform X2. (118 aa)
Pde3bPhosphodiesterase. (1011 aa)
KlKlotho. (1020 aa)
Atp6v1b2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
Flt3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
Gab2GRB2-associated-binding protein 2. (608 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
CnstConsortin. (573 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Spem2Uncharacterized protein C17orf74 homolog. (489 aa)
Spem1Spermatid maturation protein 1. (301 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (583 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
Atp6v1aV-type proton ATPase catalytic subunit A. (617 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
PtprfReceptor-type tyrosine-protein phosphatase F isoform X1. (1901 aa)
KlbBeta-klotho. (976 aa)
Pik3r4Phosphoinositide-3-kinase regulatory subunit 4. (208 aa)
Atp6v0a4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (808 aa)
Lim2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Nrd1Nardilysin; Belongs to the peptidase M16 family. (1100 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Trib3Tribbles homolog 3. (357 aa)
Atp6v1e1V-type proton ATPase subunit E 1. (215 aa)
Atp6v1c2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (436 aa)
ENSDORP00000016454annotation not available (81 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LOC105981036V-type proton ATPase subunit E 1 pseudogene. (226 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Frs2Fibroblast growth factor receptor substrate 2. (507 aa)
Atp6ap1lV-type proton ATPase subunit S1-like protein. (335 aa)
Fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (146 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
Fgfr4Fibroblast growth factor receptor. (766 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Atp6v1fV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
Atp6ap1V-type proton ATPase subunit S1. (467 aa)
Atp6v0a2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
ENSDORP00000015961annotation not available (99 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Atp6v1g3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (120 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Atp6v1g2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
Atp6v0bV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
Atp6v0d2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
Grb10Growth factor receptor-bound protein 10 isoform X2. (541 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
Atp6v1dV-type proton ATPase subunit D. (247 aa)
Atp6v1b1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (496 aa)
Atp6v1c1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (52 aa)
Atp6v0d1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
Flt3lgFms-related tyrosine kinase 3 ligand isoform X1. (181 aa)
Fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (272 aa)
Atp6v0a1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (740 aa)
IdeInsulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. (1016 aa)
Tlr9Toll-like receptor 9 isoform X3. (1029 aa)
Tcirg1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (514 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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