STRINGSTRING
Igf1 Igf1 Egf Egf Erbb3 Erbb3 Map2k2 Map2k2 Map2k1 Map2k1 Shc2 Shc2 Bad Bad Bcl2 Bcl2 Sos1 Sos1 ENSDORP00000002242 ENSDORP00000002242 Mapk3 Mapk3 Pdgfa Pdgfa Shc1 Shc1 Mtor Mtor Prkcg Prkcg Mast3 Mast3 Igf1r Igf1r Shc3 Shc3 Akt1 Akt1 Pik3cb Pik3cb Kdr Kdr Pten Pten Pik3ca Pik3ca Fgfr3 Fgfr3 Prkca Prkca Pdgfc Pdgfc Cep152 Cep152 Shc4 Shc4 Kras-2 Kras-2 Nf1 Nf1 LOC106001479 LOC106001479 Csde1 Csde1 Rps6 Rps6 Gas6 Gas6 Plcg1 Plcg1 Pik3cd Pik3cd Egfr Egfr Jak1 Jak1 Il6r Il6r Erbb2 Erbb2 Bax Bax Raf1 Raf1 Gab1 Gab1 Prkcb Prkcb Plcg2 Plcg2 Eif4e1b Eif4e1b Bcl2l11 Bcl2l11 Pik3r3 Pik3r3 Foxo3 Foxo3 Fgfr2 Fgfr2 Eif4ebp1 Eif4ebp1 Mapk1 Mapk1 Braf Braf Nrg1 Nrg1 Fgf2 Fgf2 Hgf Hgf Jak2 Jak2 Araf Araf Met Met Pdgfra Pdgfra Pik3r1 Pik3r1 Eif4e2 Eif4e2 Sos2 Sos2 Rps6kb2 Rps6kb2 Kras Kras Pdgfb Pdgfb Tgfa Tgfa LOC106000559 LOC106000559 Axl Axl Nras Nras Tbca Tbca Eif4e Eif4e LOC105987800 LOC105987800 Fgfr3-2 Fgfr3-2 ENSDORP00000023223 ENSDORP00000023223 Gsk3b Gsk3b Insr Insr Stat3 Stat3 Pdgfrb Pdgfrb LOC105987731 LOC105987731 Hras Hras Akt2 Akt2 Bcl2l1 Bcl2l1 Akt3 Akt3 Grb2 Grb2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Igf1Insulin-like growth factor I isoform X2. (130 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Erbb3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Shc2SHC-transforming protein 2. (513 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
ENSDORP00000002242annotation not available (278 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
PdgfaPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (210 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Shc3SHC-transforming protein 3. (598 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
KdrVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1352 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Fgfr3Fibroblast growth factor receptor 3. (47 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PdgfcPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
Shc4SHC-transforming protein 4. (340 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Nf1Neurofibromin isoform X1. (2841 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
Gas6Growth arrest-specific protein 6. (660 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Jak1Tyrosine-protein kinase. (1155 aa)
Il6rInterleukin-6 receptor subunit alpha. (445 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
BaxApoptosis regulator BAX. (143 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
PrkcbProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (621 aa)
Plcg2Phosphoinositide phospholipase C. (1065 aa)
Eif4e1bEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (231 aa)
Bcl2l11Bcl-2-like protein 11 isoform X1. (200 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Foxo3Forkhead box protein O3. (672 aa)
Fgfr2Fibroblast growth factor receptor. (819 aa)
Eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
Jak2Tyrosine-protein kinase. (1037 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
MetHepatocyte growth factor receptor. (1382 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Eif4e2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (208 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TgfaProtransforming growth factor alpha. (156 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
AxlTyrosine-protein kinase receptor UFO. (858 aa)
NrasGTPase NRas. (189 aa)
TbcaTubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
Eif4eEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
LOC105987800Vascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (185 aa)
Fgfr3-2Fibroblast growth factor receptor. (176 aa)
ENSDORP00000023223annotation not available (74 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
LOC105987731Uncharacterized protein LOC105987731. (169 aa)
HrasGTPase HRas isoform X1. (192 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Bcl2l1Bcl-2-like protein 1 isoform X1. (234 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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