STRINGSTRING
Notch3 Notch3 ENSDORP00000018543 ENSDORP00000018543 Ptrhd1 Ptrhd1 Braf Braf Adcy9 Adcy9 Mapk1 Mapk1 Tex21 Tex21 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Sp1 Sp1 Raf1 Raf1 Bax Bax Prkaca Prkaca Erbb2 Erbb2 Ccdc170 Ccdc170 Mapk13 Mapk13 Jag2 Jag2 E2f1 E2f1 Mmp2 Mmp2 Egfr Egfr Ncor1 Ncor1 Hbegf Hbegf Pik3cd Pik3cd Adcy4 Adcy4 Bik Bik Csde1 Csde1 LOC106001479 LOC106001479 Kras-2 Kras-2 Adcy2 Adcy2 Dll4 Dll4 Shc4 Shc4 Cep152 Cep152 Adcy7 Adcy7 Esr1 Esr1 Mapk10 Mapk10 Pik3ca Pik3ca Adcy3 Adcy3 Cdk4 Cdk4 Mdm2 Mdm2 Adcy8 Adcy8 Pik3cb Pik3cb Akt1 Akt1 Shc3 Shc3 Jag1 Jag1 Adcy6 Adcy6 Med1 Med1 Igf1r Igf1r Gnas Gnas Mast3 Mast3 Mapk9 Mapk9 Mtor Mtor Shc1 Shc1 E2f2 E2f2 Mapk3 Mapk3 Sos1 Sos1 Ncoa3 Ncoa3 Bcl2 Bcl2 Abcb11 Abcb11 Mapk12 Mapk12 Bad Bad Shc2 Shc2 Map2k1 Map2k1 Map2k2 Map2k2 Notch2 Notch2 Dll3 Dll3 Cdkn1b Cdkn1b Adcy1 Adcy1 ENSDORP00000000697 ENSDORP00000000697 Adcy5 Adcy5 Igf1 Igf1 Gpsm3 Gpsm3 Insr Insr Mapk14 Mapk14 Notch4 Notch4 Gper1 Gper1 Hras Hras Mapk8 Mapk8 Cdkn2c Cdkn2c Fos Fos Akt2 Akt2 Notch1 Notch1 Esr2 Esr2 Akt3 Akt3 Grb2 Grb2 Trp53 Trp53 E2f3 E2f3 ENSDORP00000023223 ENSDORP00000023223 Nras Nras LOC106000559 LOC106000559 Kras Kras Rps6kb2 Rps6kb2 Sos2 Sos2 Pik3r1 Pik3r1 Prkacb Prkacb Ptk2 Ptk2 Araf Araf Rb1 Rb1 Carm1 Carm1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Notch3Neurogenic locus notch homolog protein 3. (2133 aa)
ENSDORP00000018543annotation not available (129 aa)
Ptrhd1Putative peptidyl-tRNA hydrolase PTRHD1. (146 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Adcy9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1330 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Tex21Coiled-coil domain-containing protein 170-like. (575 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Sp1Transcription factor Sp1. (786 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
BaxApoptosis regulator BAX. (143 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
Ccdc170Coiled-coil domain-containing protein 170. (670 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Jag2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (833 aa)
E2f1Transcription factor E2F1. (436 aa)
Mmp272 kDa type IV collagenase. (126 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Ncor1Nuclear receptor corepressor 1. (1652 aa)
HbegfProheparin-binding EGF-like growth factor. (206 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
BikBcl-2-interacting killer. (149 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (854 aa)
Dll4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (706 aa)
Shc4SHC-transforming protein 4. (340 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
Adcy7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
Esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Adcy3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
Cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (446 aa)
Adcy8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Shc3SHC-transforming protein 3. (598 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1546 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
GnasGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (394 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
E2f2Transcription factor E2F2. (308 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Ncoa3Nuclear receptor coactivator 3. (1412 aa)
Bcl2Apoptosis regulator Bcl-2. (196 aa)
Abcb11Bile salt export pump. (1261 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Shc2SHC-transforming protein 2. (513 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Notch2Neurogenic locus notch homolog protein 2. (2322 aa)
Dll3LOW QUALITY PROTEIN: delta-like protein 3. (606 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
Adcy1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (937 aa)
ENSDORP00000000697annotation not available (678 aa)
Adcy5Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1186 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
Gpsm3G-protein-signaling modulator 3. (165 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Notch4Neurogenic locus notch homolog protein 4. (1953 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
HrasGTPase HRas isoform X1. (192 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Cdkn2cCyclin-dependent kinase 4 inhibitor C. (168 aa)
FosProto-oncogene c-Fos. (380 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Notch1Notch 1. (2304 aa)
Esr2Estrogen receptor beta. (550 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Trp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (356 aa)
E2f3Transcription factor E2F3 isoform X1. (461 aa)
ENSDORP00000023223annotation not available (74 aa)
NrasGTPase NRas. (189 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PrkacbcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (351 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Rb1Retinoblastoma-associated protein isoform X1. (926 aa)
Carm1LOW QUALITY PROTEIN: histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (574 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.