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Cdkn1b Cdkn1b Egf Egf Stat5a Stat5a Pak2 Pak2 Hras Hras Cdkn1a Cdkn1a Pak6 Pak6 Pak4-2 Pak4-2 Gsk3b Gsk3b ENSDORP00000023223 ENSDORP00000023223 Nras Nras Msantd3 Msantd3 Crk Crk LOC106000559 LOC106000559 Tgfa Tgfa Kras Kras Crkl Crkl Rps6kb2 Rps6kb2 Sos2 Sos2 Camk2d Camk2d Cbl Cbl Pik3r1 Pik3r1 Ptk2 Ptk2 Araf Araf Nrg1 Nrg1 Camk2a Camk2a Braf Braf Nrg3 Nrg3 Mapk1 Mapk1 Pak1 Pak1 Eif4ebp1 Eif4ebp1 Rem1 Rem1 Pik3r3 Pik3r3 Camk2b Camk2b Btc Btc Plcg2 Plcg2 Prkcb Prkcb Gab1 Gab1 Raf1 Raf1 Tmeff1 Tmeff1 Erbb2 Erbb2 Nck1 Nck1 Epgn Epgn Rrad Rrad Egfr Egfr Erbb4 Erbb4 Hbegf Hbegf Abl2 Abl2 Pik3cd Pik3cd Plcg1 Plcg1 Csde1 Csde1 LOC106001479 LOC106001479 Kras-2 Kras-2 Shc4 Shc4 Cep152 Cep152 Cblb Cblb Prkca Prkca Mapk10 Mapk10 Pik3ca Pik3ca Arsi Arsi Pak7 Pak7 Grb2 Grb2 Akt3 Akt3 Akt2 Akt2 Elk3 Elk3 ENSDORP00000026600 ENSDORP00000026600 Myc Myc Mapk8 Mapk8 Map2k7 Map2k7 Ereg Ereg Pak4 Pak4 Pik3cb Pik3cb Akt1 Akt1 Alkbh4 Alkbh4 Camk2g Camk2g Shc3 Shc3 Rem2 Rem2 Mast3 Mast3 Areg Areg Prkcg Prkcg Mapk9 Mapk9 Gem Gem Mtor Mtor Shc1 Shc1 Nck2 Nck2 Mapk3 Mapk3 Tmeff2 Tmeff2 Nrg4 Nrg4 ENSDORP00000002242 ENSDORP00000002242 ENSDORP00000002235 ENSDORP00000002235 Sos1 Sos1 Pak3 Pak3 Bad Bad Ppp1r14bl Ppp1r14bl Shc2 Shc2 Map2k1 Map2k1 Map2k2 Map2k2 Erbb3 Erbb3 Elk1 Elk1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Stat5aSignal transducer and activator of transcription. (793 aa)
Pak2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (507 aa)
HrasGTPase HRas isoform X1. (192 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (161 aa)
Pak6Non-specific serine/threonine protein kinase. (668 aa)
Pak4-2Non-specific serine/threonine protein kinase. (110 aa)
Gsk3bGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ENSDORP00000023223annotation not available (74 aa)
NrasGTPase NRas. (189 aa)
Msantd3myb/SANT-like DNA-binding domain-containing protein 3. (275 aa)
CrkAdapter molecule crk. (304 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
TgfaProtransforming growth factor alpha. (156 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
CrklCrk-like protein. (303 aa)
Rps6kb2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1; Belongs to the protein kinase superfamily. (533 aa)
CblE3 ubiquitin-protein ligase CBL. (51 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform isoform X1. (700 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (488 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Nrg3Pro-neuregulin-3, membrane-bound isoform. (680 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Pak1Non-specific serine/threonine protein kinase. (544 aa)
Eif4ebp1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
Rem1GTP-binding protein REM 1. (252 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Camk2bCalcium/calmodulin-dependent protein kinase type II subunit beta. (644 aa)
BtcProbetacellulin. (163 aa)
Plcg2Phosphoinositide phospholipase C. (1065 aa)
PrkcbProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (621 aa)
Gab1GRB2-associated-binding protein 1. (707 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
Tmeff1Tomoregulin-1. (385 aa)
Erbb2Receptor protein-tyrosine kinase. (1255 aa)
Nck1Cytoplasmic protein. (377 aa)
EpgnEpigen isoform X5. (153 aa)
RradGTP-binding protein RAD. (296 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Erbb4Receptor protein-tyrosine kinase. (1308 aa)
HbegfProheparin-binding EGF-like growth factor. (206 aa)
Abl2Tyrosine-protein kinase. (1132 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LOC106001479Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (492 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Shc4SHC-transforming protein 4. (340 aa)
Cep152Centrosomal protein of 152 kDa. (655 aa)
CblbE3 ubiquitin-protein ligase CBL-B isoform X2. (939 aa)
PrkcaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ArsiArylsulfatase I. (573 aa)
Pak7Non-specific serine/threonine protein kinase. (338 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Elk3ETS domain-containing protein Elk-3. (407 aa)
ENSDORP00000026600annotation not available (64 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
EregProepiregulin. (163 aa)
Pak4Non-specific serine/threonine protein kinase. (587 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Alkbh4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform X1. (301 aa)
Camk2gCalcium/calmodulin-dependent protein kinase type II subunit gamma. (515 aa)
Shc3SHC-transforming protein 3. (598 aa)
Rem2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
AregAmphiregulin. (245 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
Shc1SHC-transforming protein 1 isoform X2. (473 aa)
Nck2Cytoplasmic protein. (380 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Tmeff2Tomoregulin-2 isoform X1. (374 aa)
Nrg4Pro-neuregulin-4, membrane-bound isoform. (110 aa)
ENSDORP00000002242annotation not available (278 aa)
ENSDORP00000002235annotation not available (390 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Pak3Non-specific serine/threonine protein kinase. (559 aa)
BadBcl2-associated agonist of cell death isoform X1. (154 aa)
Ppp1r14blProtein phosphatase 1 regulatory subunit 14B. (141 aa)
Shc2SHC-transforming protein 2. (513 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Erbb3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
Elk1ETS domain-containing protein Elk-1. (430 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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