STRINGSTRING
G6pc G6pc Myo9b Myo9b Prkaa1 Prkaa1 Atm Atm Igf1 Igf1 Stk11 Stk11 Egf Egf Cdkn1b Cdkn1b Tssk4 Tssk4 Plk1 Plk1 Plk4 Plk4 Map2k2 Map2k2 Map2k1 Map2k1 Sod2 Sod2 Pck2 Pck2 Sgk3 Sgk3 Mapk12 Mapk12 Foxo4 Foxo4 Sos1 Sos1 Fbxo32 Fbxo32 Mapk3 Mapk3 Tgfb1 Tgfb1 Tssk2 Tssk2 Gem Gem Mapk9 Mapk9 Tgfb2 Tgfb2 Mast3 Mast3 Homer3 Homer3 Igf1r Igf1r Cdk3 Cdk3 Rem2 Rem2 Prmt3 Prmt3 Grap Grap G6pc2 G6pc2 Bcl6b Bcl6b Plk3 Plk3 Bcl6 Bcl6 ENSDORP00000005529 ENSDORP00000005529 Akt1 Akt1 Pik3cb Pik3cb Rnf111 Rnf111 Ccng2 Ccng2 Mdm2 Mdm2 Cat Cat Snapin Snapin Prkag2 Prkag2 Tssk6 Tssk6 Pten Pten Smad4 Smad4 Homer1 Homer1 Pik3ca Pik3ca Prkaa2 Prkaa2 Csnk1e Csnk1e Mapk10 Mapk10 Plk2 Plk2 Nlk Nlk Ep300 Ep300 Slc2a4 Slc2a4 Pck1 Pck1 Il10 Il10 Kras-2 Kras-2 Csde1 Csde1 Gadd45a Gadd45a Homer2 Homer2 Faslg Faslg Pdpk1 Pdpk1 Chuk Chuk Gadd45g Gadd45g Usp7 Usp7 Irs1 Irs1 Pik3cd Pik3cd Bnip3 Bnip3 Irs4 Irs4 Rasgef1a Rasgef1a Ikbkb Ikbkb Tgfb3 Tgfb3 Egfr Egfr Skp2 Skp2 Rrad Rrad Grb2 Grb2 Tssk3 Tssk3 G6pc3 G6pc3 Myo9a Myo9a Tnfsf10 Tnfsf10 Akt3 Akt3 Foxg1 Foxg1 Prkab2 Prkab2 Fbxo25 Fbxo25 Akt2 Akt2 Suco Suco Prmt1 Prmt1 Rasl11b Rasl11b LOC105998647 LOC105998647 Mapk8 Mapk8 Hras Hras ENSDORP00000025450 ENSDORP00000025450 Ldlrad4 Ldlrad4 Rag1 Rag1 Atg12 Atg12 Mapk14 Mapk14 Stat3 Stat3 Insr Insr Cdkn1a Cdkn1a Tssk1b Tssk1b Tssk5 Tssk5 Il7r Il7r Prkag1 Prkag1 Foxo6 Foxo6 Smad3 Smad3 Rbl2 Rbl2 Nras Nras ENSDORP00000022426 ENSDORP00000022426 Crebbp Crebbp Gabarapl1 Gabarapl1 Slc35e3 Slc35e3 LOC106000559 LOC106000559 Ins Ins Cdkn2b Cdkn2b Prkab1 Prkab1 Rasgef1b Rasgef1b LOC105981524 LOC105981524 Ccnd2 Ccnd2 Kras Kras Sos2 Sos2 S1pr1 S1pr1 Foxj2 Foxj2 Sirt1 Sirt1 Plk5 Plk5 Pik3r1 Pik3r1 LOC105998647-2 LOC105998647-2 Gabarap Gabarap Araf Araf Gadd45b Gadd45b LOC106002348 LOC106002348 Gabarapl2 Gabarapl2 Sgk1 Sgk1 Rag2 Rag2 ENSDORP00000018543 ENSDORP00000018543 Tgfbr1 Tgfbr1 ENSDORP00000018243 ENSDORP00000018243 S1pr4 S1pr4 Rnf6 Rnf6 ENSDORP00000017661 ENSDORP00000017661 Prkag3 Prkag3 Braf Braf Mapk1 Mapk1 Ccnb2 Ccnb2 Rem1 Rem1 Foxo3 Foxo3 Prmt8 Prmt8 Cdk2 Cdk2 Pik3r3 Pik3r3 Ccnd1 Ccnd1 Setd7 Setd7 Agap2 Agap2 Bcl2l11 Bcl2l11 Foxj3 Foxj3 Raf1 Raf1 Foxo1 Foxo1 Tgfbr2 Tgfbr2 Mapk13 Mapk13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G6pcGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
Myo9bUnconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1887 aa)
Prkaa1Non-specific serine/threonine protein kinase. (538 aa)
AtmSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
Igf1Insulin-like growth factor I isoform X2. (130 aa)
Stk11Serine/threonine-protein kinase STK11 isoform X1; Belongs to the protein kinase superfamily. (310 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (664 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (106 aa)
Tssk4Testis-specific serine/threonine-protein kinase 4 isoform X2; Belongs to the protein kinase superfamily. (321 aa)
Plk1Serine/threonine-protein kinase PLK. (580 aa)
Plk4Serine/threonine-protein kinase PLK4. (902 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (375 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
Pck2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (643 aa)
Sgk3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (493 aa)
Mapk12Mitogen-activated protein kinase. (351 aa)
Foxo4Forkhead box protein O4. (504 aa)
Sos1Son of sevenless homolog 1. (1301 aa)
Fbxo32F-box only protein 32 isoform X1. (355 aa)
Mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (374 aa)
Tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (130 aa)
Tssk2Testis-specific serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
GemGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
Mapk9Mitogen-activated protein kinase. (382 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (443 aa)
Mast3Microtubule associated serine/threonine kinase 3. (71 aa)
Homer3Homer protein homolog 3. (101 aa)
Igf1rTyrosine-protein kinase receptor. (923 aa)
Cdk3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (305 aa)
Rem2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
Prmt3Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (532 aa)
GrapGRB2-related adapter protein isoform X1. (217 aa)
G6pc2Glucose-6-phosphatase 2. (245 aa)
Bcl6bB-cell CLL/lymphoma 6 member B protein. (315 aa)
Plk3Serine/threonine-protein kinase PLK. (647 aa)
Bcl6B-cell lymphoma 6 protein. (706 aa)
ENSDORP00000005529annotation not available (297 aa)
Akt1Non-specific serine/threonine protein kinase. (188 aa)
Pik3cbPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
Rnf111E3 ubiquitin-protein ligase Arkadia isoform X3. (991 aa)
Ccng2cyclin-G2; Belongs to the cyclin family. (344 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (446 aa)
CatCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
SnapinSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
Prkag25'-AMP-activated protein kinase subunit gamma-2. (191 aa)
Tssk6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PtenPhosphatase and tensin homolog. (396 aa)
Smad4Mothers against decapentaplegic homolog. (528 aa)
Homer1Homer protein homolog 1. (361 aa)
Pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Prkaa2Non-specific serine/threonine protein kinase. (549 aa)
Csnk1eCasein kinase I isoform epsilon isoform X1; Belongs to the protein kinase superfamily. (416 aa)
Mapk10Mitogen-activated protein kinase. (486 aa)
Plk2Serine/threonine-protein kinase PLK2. (628 aa)
NlkSerine/threonine-protein kinase NLK. (428 aa)
Ep300Histone acetyltransferase p300. (2345 aa)
Slc2a4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
Pck1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
Il10Interleukin-10. (178 aa)
Kras-2GTPase KRas isoform X4. (189 aa)
Csde1Cold shock domain-containing protein E1 isoform X1. (798 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (166 aa)
Homer2Homer protein homolog 2 isoform X2. (355 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (276 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X1. (552 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Gadd45gGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Usp7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (891 aa)
Irs1Insulin receptor substrate 1. (1239 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Bnip3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (202 aa)
Irs4Insulin receptor substrate 4. (1262 aa)
Rasgef1aras-GEF domain-containing family member 1A. (344 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta. (732 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EgfrReceptor protein-tyrosine kinase. (1215 aa)
Skp2S-phase kinase-associated protein 2 isoform X1. (424 aa)
RradGTP-binding protein RAD. (296 aa)
Grb2Growth factor receptor-bound protein 2. (217 aa)
Tssk3Testis-specific serine/threonine-protein kinase 3. (268 aa)
G6pc3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
Myo9aUnconventional myosin-IXa isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2627 aa)
Tnfsf10Tumor necrosis factor ligand superfamily member. (288 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Foxg1Forkhead box protein G1. (419 aa)
Prkab25'-AMP-activated protein kinase subunit beta-2. (268 aa)
Fbxo25F-box only protein 25 isoform X2. (365 aa)
Akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SucoSUN domain-containing ossification factor. (1216 aa)
Prmt1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
Rasl11bRas-like protein family member 11B. (219 aa)
LOC105998647G2/mitotic-specific cyclin-B1-like. (332 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
HrasGTPase HRas isoform X1. (192 aa)
ENSDORP00000025450annotation not available (102 aa)
Ldlrad4Low-density lipoprotein receptor class A domain-containing protein 4. (306 aa)
Rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
Atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (85 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
InsrTyrosine-protein kinase receptor. (1183 aa)
Cdkn1aCyclin-dependent kinase inhibitor 1. (161 aa)
Tssk1bTestis-specific serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (362 aa)
Tssk5Testis-specific serine/threonine-protein kinase 5-like. (342 aa)
Il7rInterleukin-7 receptor subunit alpha. (458 aa)
Prkag15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
Foxo6Forkhead box protein O6. (382 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Rbl2Retinoblastoma-like protein 2. (1051 aa)
NrasGTPase NRas. (189 aa)
ENSDORP00000022426annotation not available (103 aa)
CrebbpCREB-binding protein. (2432 aa)
Gabarapl1Gamma-aminobutyric acid receptor-associated protein-like 1. (87 aa)
Slc35e3Solute carrier family 35 member E3. (313 aa)
LOC106000559Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1029 aa)
InsInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
Cdkn2bCyclin-dependent kinase 4 inhibitor B-like. (139 aa)
Prkab15'-AMP-activated protein kinase subunit beta-1. (270 aa)
Rasgef1bras-GEF domain-containing family member 1B isoform X1. (473 aa)
LOC105981524Serine/threonine-protein kinase 4. (107 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (224 aa)
KrasKirsten rat sarcoma viral oncogene homolog. (163 aa)
Sos2Son of sevenless homolog 2. (1320 aa)
S1pr1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Foxj2Forkhead box J2. (451 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (646 aa)
Plk5Serine/threonine-protein kinase PLK. (458 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LOC105998647-2LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like; Belongs to the cyclin family. (396 aa)
GabarapGamma-aminobutyric acid receptor-associated protein. (117 aa)
ArafSerine/threonine-protein kinase A-Raf. (606 aa)
Gadd45bGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
LOC106002348Glucose-6-phosphatase 2-like. (109 aa)
Gabarapl2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
Sgk1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
Rag2V(D)J recombination-activating protein 2. (527 aa)
ENSDORP00000018543annotation not available (129 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
ENSDORP00000018243annotation not available (251 aa)
S1pr4Sphingosine 1-phosphate receptor 4. (388 aa)
Rnf6E3 ubiquitin-protein ligase RNF6. (683 aa)
ENSDORP00000017661annotation not available (180 aa)
Prkag35'-AMP-activated protein kinase subunit gamma-3. (490 aa)
BrafSerine/threonine-protein kinase B-raf. (705 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
Ccnb2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (380 aa)
Rem1GTP-binding protein REM 1. (252 aa)
Foxo3Forkhead box protein O3. (672 aa)
Prmt8Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (362 aa)
Cdk2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
Ccnd1G1/S-specific cyclin-D1. (156 aa)
Setd7Histone-lysine N-methyltransferase SETD7. (362 aa)
Agap2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (1171 aa)
Bcl2l11Bcl-2-like protein 11 isoform X1. (200 aa)
Foxj3Forkhead box protein J3 isoform X1. (622 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (590 aa)
Foxo1Forkhead box protein O1. (537 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
Mapk13Mitogen-activated protein kinase. (334 aa)
Your Current Organism:
Dipodomys ordii
NCBI taxonomy Id: 10020
Other names: D. ordii
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